Decoding Depression Severity From Intracranial Neural Activity

Biological Psychiatry · 2023 · 49 citations

• Computer Science
• Medicine
• Neuroscience

BACKGROUND: Disorders of mood and cognition are prevalent, disabling, and notoriously difficult to treat. Fueling this challenge in treatment is a significant gap in our understanding of their neurophysiological basis. METHODS: We recorded high-density neural activity from intracranial electrodes implanted in depression-relevant prefrontal cortical regions in 3 human subjects with severe depression. Neural recordings were labeled with depression severity scores across a wide dynamic range using an adaptive assessment that allowed sampling with a temporal frequency greater than that possible with typical rating scales. We modeled these data using regularized regression techniques with region selection to decode depression severity from the prefrontal recordings. RESULTS: Across prefrontal regions, we found that reduced depression severity is associated with decreased low-frequency neural activity and increased high-frequency activity. When constraining our model to decode using a single region, spectral changes in the anterior cingulate cortex best predicted depression severity in all 3 subjects. Relaxing this constraint revealed unique, individual-specific sets of spatiospectral features predictive of symptom severity, reflecting the heterogeneous nature of depression. CONCLUSIONS: The ability to decode depression severity from neural activity increases our fundamental understanding of how depression manifests in the human brain and provides a target neural signature for personalized neuromodulation therapies.

Neuromatch Academy: Teaching Computational Neuroscience with Global Accessibility.

Trends in Cognitive Sciences · 2021 · 37 citations

• Computer Science
• Psychology
• Mathematics education

Neuromatch Academy (NMA) designed and ran a fully online 3-week Computational Neuroscience Summer School for 1757 students with 191 teaching assistants (TAs) working in virtual inverted (or flipped) classrooms and on small group projects. Fourteen languages, active community management, and low cost allowed for an unprecedented level of inclusivity and universal accessibility.

A How-to-Model Guide for Neuroscience

eNeuro · 2020 · 39 citations

• Computer Science
• Artificial Intelligence
• Computer Science

Within neuroscience, models have many roles, including driving hypotheses, making assumptions explicit, synthesizing knowledge, making experimental predictions, and facilitating applications to medicine. While specific modeling techniques are often taught, the process of constructing models for a given phenomenon or question is generally left opaque. Here, informed by guiding many students through modeling exercises at our summer school in CoSMo (Computational Sensory-Motor Neuroscience), we provide a practical 10-step breakdown of the modeling process. This approach makes choices and criteria more explicit and replicable. Experiment design has long been taught in neuroscience; the modeling process should receive the same attention.