About

Joseph Calabrese is the Associate Dean of Students and a Clinical Professor of General Dentistry at the Henry M. Goldman School of Dental Medicine. He is also the Director of the Geriatric Dentistry Fellowship Program. His educational background includes a Fellowship in Geriatric Dental Medicine from Boston University School of Medicine obtained in 1994, a CAGS in Advanced Education in General Dentistry from Boston University Henry M. Goldman School of Dental Medicine in 1992, and a DMD from the same institution in 1991. Dr. Calabrese's roles involve overseeing student affairs and contributing to the academic and clinical training within the field of general dentistry, with a particular focus on geriatric dentistry.

Research topics

• Sociology
• Medicine
• Gerontology
• Political Science
• Family medicine
• Environmental health
• Psychiatry
• Demography
• Dentistry
• Pathology

Selected publications

• Estimation of Oral Disease Burden among Older Adults in LTC: A Scoping Review

  International Journal of Environmental Research and Public Health · 2024 · 10 citations

  • Medicine
  • Gerontology
  • Dentistry

  Oral health is an essential part of healthy aging and very little data exists around the disease burden for older adults in a long-term care setting. The aim of this scoping review was to estimate the disease burden of dental caries, periodontal disease, and tooth loss among older adults in Long-Term Care (LTC). This scoping review was conducted in accordance with the Joanna Briggs Institute methodology. A detailed strategy was used to conduct a comprehensive search of electronic databases: PubMed, Embase, and Dentistry and Oral Sciences Source (DOSS). The Rayyan AI platform was used to screen abstracts for assessment by one of five co-investigators. Results indicate that only one in three might have a functional dentition upon entry into LTC, and among those who are dentate, most might expect to develop at least one new coronal and one new root caries lesion each year. There is a need to better document the disease experiences of this group to tailor approaches to care that might reduce the avoidable suffering as a result of dental caries and periodontal disease.

  PublisherOA PDFDOI

• Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

  Biological Psychiatry · 2021 · 67 citations

  • Computer Science
  • Clinical psychology
  • Psychology

  BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. RESULTS: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. CONCLUSIONS: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.

  PublisherOA PDFDOI

• Demographics and Oral Health Care Utilization for Older Adults

  Dental Clinics of North America · 2021 · 14 citations

  1st authorCorresponding
  • Political Science
  • Sociology
  • Gerontology
  PublisherDOI

• Genomic influences on self-reported childhood maltreatment

  Translational Psychiatry · 2020 · 84 citations

  • Psychology
  • Clinical psychology
  • Psychiatry

  ), although we show evidence that our top hits may be specific to childhood maltreatment. This is the first large-scale genetic study to identify specific variants associated with self-reported childhood maltreatment. Speculatively, FOXP genes might influence externalizing traits and so be relevant to childhood maltreatment. Alternatively, these variants may be associated with a greater likelihood of reporting maltreatment. A clearer understanding of the genetic relationships of childhood maltreatment, including particular abuse subtypes, with a range of phenotypes, may ultimately be useful in in developing targeted treatment and prevention strategies.

  DOI

Frequent coauthors

• Kadambari Rawal

  Boston University

  25 shared

• Michelle Henshaw

  Boston University

  11 shared

• Laura Kaufman

  3 shared

• Blasé Brown

  University of Illinois Chicago

  3 shared

• Ernest I. Mandel

  Harvard University

  2 shared

• Bathsheba Turton

  Boston University

  2 shared

• Judith A. Jones

  University of Detroit Mercy

  2 shared

• David Pimentel

  Rice University

  1 shared

Education

• Other

  Boston University Henry M. Goldman School of Dental Medicine

  1991

• Other, Advanced Education in General Dentistry

  Boston University Henry M. Goldman School of Dental Medicine

  1992

• Other, Geriatric Dental Medicine

  Boston University School of Medicine

  1994

Similar researchers at Boston University

• Alexa S. Beiserh-188
• David Boash-156
• Benjamin Sovacoolh-143
• Kathryn L. Lunettah-132
• Ranga Mynenih-130