Stephen Graham Jones
· Professor of Distinction • Ineva Reilly Baldwin Endowed ChairVerifiedUniversity of Colorado Boulder · English
Active 1958–2025
About
Stephen Graham Jones is a Professor of Distinction and the Ineva Reilly Baldwin Endowed Chair at the University of Colorado Boulder in the Department of English. He is a New York Times bestselling author of nearly thirty-five novels and collections, including works in various genres such as horror, science fiction, fantasy, westerns, thriller, mystery, noir, and young adult literature. His writing also encompasses novellas and comic books, notably including the comic book Earthdivers and the novel Mongrels. Jones has received numerous awards and honors for his contributions to literature, including the NEA award, the Texas Institute of Letters Award for Fiction, the Los Angeles Times Ray Bradbury Prize, the Mark Twain American Voice in Literature Award, the August Derleth British Fantasy Award for Best Horror Novel, the Independent Publishers Award for Multicultural Fiction, and the American Indian Festival of Words Writers Award among others. He has been inducted into the Texas Literary Hall of Fame, been a finalist for the World Fantasy Award and the Eisner Award, and has been recognized by Bloody Disgusting’s Top Ten Horror Novels. His areas of specialty include Creative Writing, Ethnic American Literature, Literature of the Americas, Post Colonial Literature, Popular Culture, Film, Digital Media, and Comic Books. His work often explores themes within ethnic American literature and popular genres, contributing significantly to contemporary American literary and cultural discourse.
Research topics
- Sociology
- Social Science
- Medicine
- Political Science
- Biology
- Environmental ethics
- Internal medicine
- Chemistry
- Veterinary medicine
- Immunology
- Geography
- Pharmacology
- History
- Cancer research
- Traditional medicine
- Classics
- Philosophy
Selected publications
University of Pittsburgh Press eBooks · 2025-04-29
book-chapter1st authorCorresponding2023-03-31
preprintOpen access<p>Supplementary data</p>
2023-03-31
preprintOpen access<p>Supplementary data</p>
2023
- Cancer research
- Medicine
- Pharmacology
<div>AbstractPurpose:<p>Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-targeting agents have validated MSLN as a promising target for therapeutic intervention, but therapies with improved efficacy are still needed to address the significant unmet medical need posed by MSLN-expressing cancers.</p>Experimental Design:<p>We designed HPN536, a 53-kDa, trispecific, T-cell–activating protein-based construct, which binds to MSLN-expressing tumor cells, CD3ϵ on T cells, and to serum albumin. Experiments were conducted to assess the potency, activity, and half-life of HPN536 in <i>in vitro</i> assays, rodent models, and in nonhuman primates (NHP).</p>Results:<p>HPN536 binds to MSLN-expressing tumor cells and to CD3ϵ on T cells, leading to T-cell activation and potent redirected target cell lysis. A third domain of HPN536 binds to serum albumin for extension of plasma half-life. In cynomolgus monkeys, HPN536 at doses ranging from 0.1 to 10 mg/kg demonstrated MSLN-dependent pharmacologic activity, was well tolerated, and showed pharmacokinetics in support of weekly dosing in humans.</p>Conclusions:<p>HPN536 is potent, is well tolerated, and exhibits extended half-life in NHPs. It is currently in phase I clinical testing in patients with MSLN-expressing malignancies (NCT03872206).</p></div>
2023-03-31
preprintOpen access<div>AbstractPurpose:<p>Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-targeting agents have validated MSLN as a promising target for therapeutic intervention, but therapies with improved efficacy are still needed to address the significant unmet medical need posed by MSLN-expressing cancers.</p>Experimental Design:<p>We designed HPN536, a 53-kDa, trispecific, T-cell–activating protein-based construct, which binds to MSLN-expressing tumor cells, CD3ϵ on T cells, and to serum albumin. Experiments were conducted to assess the potency, activity, and half-life of HPN536 in <i>in vitro</i> assays, rodent models, and in nonhuman primates (NHP).</p>Results:<p>HPN536 binds to MSLN-expressing tumor cells and to CD3ϵ on T cells, leading to T-cell activation and potent redirected target cell lysis. A third domain of HPN536 binds to serum albumin for extension of plasma half-life. In cynomolgus monkeys, HPN536 at doses ranging from 0.1 to 10 mg/kg demonstrated MSLN-dependent pharmacologic activity, was well tolerated, and showed pharmacokinetics in support of weekly dosing in humans.</p>Conclusions:<p>HPN536 is potent, is well tolerated, and exhibits extended half-life in NHPs. It is currently in phase I clinical testing in patients with MSLN-expressing malignancies (NCT03872206).</p></div>
Veterinary Medicine and Animal Health, 2000–2020
Cambridge University Press eBooks · 2022-08-11
book-chapter1st authorCorrespondingThe numbers of pets, availability of goods and services for them, and the veterinary profession’s attention to companion animal medicine are increasing (especially in Asia and Latin America). The concept of "anthropomorphism" (attributing human characteristics to animals) contributes to the idea that family pets are worthy of expensive care. Animal welfare activism expanded in Western societies and became politicized in Europe. These changes led to reductions in the use of laboratory animals and veterinarians’ increased attention to animal suffering. While traditional healing systems are often combined with Western veterinary medicine around the world, in some places the standard of animal care was based on that of human hospitals. Veterinarians adopted new technologies, including CT and MRI scanning and genetic testing. Personal computers, the internet, and mobile phones have revolutionized veterinary practice in some areas; this required veterinarians to learn new skills. In 2011–2012, veterinarians celebrated the World Veterinary Year, (250th anniversary of the first European veterinary school) and the eradication of rinderpest from the world (a triumph for veterinary international cooperation). Veterinarians have been major drivers of "One Health," the most recent effort to combine all aspects of health care for animals, the environment, and humans to address ecosystem destruction and prevent disease outbreaks.
Formal Education for Animal Healing
Cambridge University Press eBooks · 2022-08-11
book-chapter1st authorCorrespondingDevelopments in international trade, colonialism, and conquest created the military needs (healthy army horses) and economic needs (controlling great animal plagues) that shaped the professionalization of modern veterinary medicine in Europe and beyond. This chapter analyzes how the circulation of veterinary knowledge was organized in the eighteenth and nineteenth centuries, amidst the challenges of animal disease outbreaks and battlefield injuries that had accompanied war and trade. It examines how modern veterinary schools emerged from European Enlightenment pragmatism and French physiocrat economics, and why and how this model of education spread around the world. State promotion and regulation of veterinary education and professionalization of veterinary practitioners increased, augmenting the traditional roles of herders and healers in many areas. Veterinarians educated in this formal European tradition slowly expanded their share of the market for veterinary services as their numbers and state-sponsored influence grew. The development and spread of the eighteenth-century European veterinary regime was a product of its time. It fulfilled crucial social, political, military, and cultural needs during subsequent decades of increasing industrialization and imperialism affecting the globe.
A Concise History of Veterinary Medicine
2022 · 12 citations
1st authorCorresponding- Political Science
- Social Science
- Veterinary medicine
From Ayurvedic texts to botanical medicines to genomics, ideas and expertise about veterinary healing have circulated between cultures through travel, trade, and conflict. In this broad-ranging and accessible study spanning 400 years of history, Susan D. Jones and Peter A. Koolmees present the first global history of veterinary medicine and animal healing. Drawing on inter-disciplinary and multi-disciplinary perspectives, this book addresses how attitudes toward animals, disease causation theories, wars, problems of food insecurity and the professionalization and spread of European veterinary education have shaped new domains for animal healing, such as preventive medicine in intensive animal agriculture and the need for veterinarians specializing in zoo animals, wildlife, and pets. It concludes by considering the politicization of animal protection, changes in the global veterinary workforce, and concerns about disease and climate change. As mediators between humans and animals, veterinarians and other animal healers have both shaped, and been shaped by, the social, cultural, and economic roles of animals over time.
Veterinary Institutions and Animal Plagues, 1800–1900
Cambridge University Press eBooks · 2022-08-11
book-chapter1st authorCorrespondingIn the early 1800s, animal owners and local healers provided most veterinary care, and indigenous healing methods thrived around the world. Colonialism, global trade networks, and other circulations of animals led to disease outbreaks (epizootics). Rinderpest, imported by Europeans, destroyed about 90 percent of all wild and domesticated bovines in sub-Saharan Africa, causing devastating famines. European-model veterinary schools continued to spread around the world. Their graduates worked to reduce competition by developing laws and regulations that forbade non-graduates from practicing animal healing. Veterinary leaders envisioned "scientific" veterinary medicine, using microscopes and other tools. By working to establish microbiology, comparative pathology, and "one medicine," veterinarians were important co-creators of modern medicine and public health as we know them today. Ideas about disease causation included the roles of the environment and insects in spreading disease; the contagium vivum; parasitism; toxins; and several germ theories. Some veterinarians treated companion (pet) animals, whose owners valued them for emotional reasons. Associations for the humane treatment of dogs and other animals were established. Pet owners increasingly expected scientifically trained veterinarians to provide the same services for pets that their owner could expect at a hospital for humans.
Animal Healing in Trade and Conquest, 1700–1850s
Cambridge University Press eBooks · 2022-08-11 · 1 citations
book-chapter1st authorCorrespondingGlobalization is not new. From the time of ancient migrations, human activities increasingly shaped the ecologies of health and disease around the world. When the peoples of the Western and Eastern Hemispheres encountered each other, the invading Europeans brought their domesticated animals, plants, and diseases with them. These demographic and ecological transformations ushered in a new era for animal healing and veterinary medicine. How were animal diseases circulating around the world due to exploration, colonialism, war, and trade? What was the impact of these diseases on human health and well-being, and on the projects of colonialism and state formation? The impacts of large-scale animal epidemics and pandemics enabled by the ecological exchanges of animals, parasites, and pathogens are analyzed. Further, this chapter highlights the development of physiology, pathology, and new disease causation models, while investigating how medical concepts, popular beliefs, and therapies were used in animal health care.
Recent grants
Scholar's Award: Plague's Third Pandemic: A History of Disease Ecology
NSF · $75k · 2011–2016
Frequent coauthors
- 18 shared
Ramachandra Guha
- 18 shared
Adam Rome
University at Buffalo, State University of New York
- 18 shared
Christine Meisner Rosen
University of California, Berkeley
- 18 shared
P.J.E.M. van Dam
Vrije Universiteit Amsterdam
- 18 shared
Marcus Hall
University of Zurich
- 11 shared
Peter A. Koolmees
Utrecht University
- 8 shared
Patrick A. Baeuerle
Ludwig-Maximilians-Universität München
- 6 shared
Philip J. Pauly
Education
- 1997
Doctor of Philosophy, History and Sociology of Science
University of Pennsylvania
- 1990
Doctor of Veterinary Medicine, College of Veterinary Medicine
University of Illinois Urbana-Champaign
- 1986
A.B., Organismic and Evolutionary Biology
Harvard University
Awards & honors
- NEA recipient
- Texas Institute of Letters Award for Fiction
- Los Angeles Times Ray Bradbury Prize
- Mark Twain American Voice in Literature Award
- August Derleth British Fantasy Award for Best Horror Novel
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