About

Lisa Jones-Jordan, MS, PhD, has been a research associate professor in the College of Optometry at Ohio State University since 2009, having originally joined the college in 1996. She received her MS from the Ohio State University Department of Preventive Medicine in 1993 and her PhD from the OSU School of Public Health in 1996, with concentrations in epidemiology, biostatistics, and environmental health. Her research has focused on various aspects of optometry and vision science, including myopia, contact lenses, accommodative esotropia, low vision, and overnight orthokeratology. She has worked extensively on longitudinal studies such as the Orinda Longitudinal Study of Myopia and the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error, examining nearsightedness in school-aged children. Dr. Jones-Jordan has collaborated with notable researchers like Karla Zadnik and Mark Bullimore, contributing to projects on adult myopia progression and other vision-related topics. Currently, she serves as the Director of the Optometry Coordinating Center, working with multiple groups on research subjects related to children, contact lenses, and ocular health.

Research topics

• Medicine
• Ophthalmology
• Optometry
• Internal medicine
• Optics
• Physics
• Materials science
• Composite material
• Demography
• Surgery
• Gerontology
• Psychiatry
• Physical therapy
• Environmental health

Selected publications

• Twelve month refractive and axial length changes in the Israeli refractive error, activity, and devices (iREAD) study

  Scientific Reports · 2025-04-14 · 2 citations

  articleOpen access

  The Israel Refraction, Environment, and Devices (iREAD) is a longitudinal study assessing myopia risk factors in three groups of boys with distinct lifestyles. Ultra-Orthodox (N = 41), Religious (N = 53), and Secular (N = 41) boys (ages 8.6 ± 1.5 years) had eye exams at baseline and 12 months, including cycloplegic autorefraction and axial length. Ocular history, education, near work, and electronic device use were assessed. Time outdoors and physical activity were measured objectively. At 12 months, myopia prevalence increased from 32 to 40% (P = 0.02), with no group differences (P > 0.05). The Ultra-Orthodox group had a more myopic spherical equivalent refraction (SER) at baseline and 12 months than the Religious and Secular groups and more myopic shift at 12 months (P < 0.05 for all). The Ultra-Orthodox group spent less time using electronic devices, more time in school, read at an earlier age, and had higher parental myopia (P < 0.01 for all). Time outdoors and activity did not differ between groups (P > 0.05 for both). In univariate and multivariate analyses, group and parental myopia were associated with greater myopic shift of SER and axial elongation (P < 0.05). In conclusion, risk factors associated with greater myopia progression included being part of the Ultra-Orthodox educational system and number of myopic parents and not screen use.

  PublisherOA PDFDOI

• Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

  Investigative Ophthalmology & Visual Science · 2025-05-02 · 5 citations

  articleOpen access

  Purpose: To evaluate changes in subfoveal choroidal thickness and area in children wearing soft multifocal contact lenses (MFCLs) for myopia control. Methods: Analyses included 281 myopic children aged 7 to 11 years in the Bifocal Lenses in Nearsighted Kids (BLINK) Study randomly assigned to wear single vision contact lenses (SVCLs), +1.50 D add, or +2.50 D add center-distance MFCL. Subfoveal choroidal thickness and choroidal area were measured using spectral-domain optical coherence tomography before and after 2 weeks of lens wear, and then annually for 3 years. Repeated measures linear regression was used to determine the effect of contact lens wear on the choroid and test the association between choroidal changes and axial elongation. Results: After initiating contact lens wear, mean ± SE subfoveal choroidal thickness and choroidal area increased in the +2.50 D MFCL group compared with the SVCL group by 8 ± 3 µm (P = 0.003) and 0.07 ± 0.02 mm2 (P = 0.002), a difference maintained throughout the 3-year study (P ≥ 0.55). Increased choroidal thickness and area after 2 weeks in the +2.50 D MFCL group vs. SVCL group were associated with less axial elongation over 3 years (β = -0.0058 mm/µm and -0.947 mm/mm2; P = 0.02 and P = 0.006; 20% and 29% of total treatment effect, respectively). Conclusions: The choroid increased in subfoveal thickness and area after 2 weeks of +2.50 D MFCL wear, which was maintained for 3 years and was associated with slower axial elongation. However, only a portion of the treatment effect can be accounted for by the choroidal parameters.

  PublisherOA PDFDOI

• Accommodative responses in children with high and low levels of astigmatism

  Optometry and Vision Science · 2025-08-19 · 1 citations

  articleOpen access

  SIGNIFICANCE: Children with uncorrected astigmatism are often assumed to accommodate to the circle of least confusion. However, empirical evidence in children without a history of refractive correction is lacking. This study found that most children accommodate toward the anterior focal plane, with both focal planes exhibiting a lag of accommodation. PURPOSE: To examine accommodative responses by measuring refractive states of the eye during near viewing in children with uncorrected astigmatism without a history of refractive correction. METHODS: Participants aged 3 to <10 years with no history of refractive correction monocularly viewed a 20/250 letter at a 3-D demand (33 cm) while accommodative responses were measured using open-field autorefraction. Responses were classified based on the focal plane closest to the stimulus: anterior or posterior focal plane, or circle of least confusion. Cycloplegic autorefraction was used to classify participants as having low astigmatism (≤1.50 D) or high astigmatism (>1.50 D). Participants were further subdivided as having hyperopia (≥2.00 D), myopia (≥0.75 D), or emmetropia (less than 0.75 D myopia and 2.00 D hyperopia) based on their spherical cycloplegic refractive error. Chi-square analyses and Fisher exact tests were used to assess the association between accommodative response and cycloplegic refractive error classification. RESULTS: Of the 352 participants, 316 (89.8%) had low astigmatism and 36 (10.2%) had high astigmatism. In both groups, significantly more participants were classified as being focused at the anterior focal plane (low: 98.7%; high: 83.3%) than the posterior focal plane (low: 0.6%; high: 0.0%) or circle of least confusion (low: 0.6%; high: 16.7%; p<0.001). Almost all nonhyperopic participants in the low astigmatism group (99.2%) and hyperopic participants irrespective of astigmatism magnitude (low: 100%; high: 95.2%) accommodated closer to the anterior focal plane with accommodative lags in both meridians. Most nonhyperopic participants with high astigmatism also accommodated to the anterior focal plane (66.7%) and a third to the circle of least confusion (33.3%). CONCLUSIONS: In contrast to the assumption that children with astigmatism accommodate to the circle of least confusion, our findings show that most children accommodated to the anterior focal plane during near-viewing tasks, with accommodative lags in both meridians.

  PublisherDOI

• Axial Growth and Myopia Progression After Discontinuing Soft Multifocal Contact Lens Wear

  JAMA Ophthalmology · 2025-01-16 · 5 citations

  letterOpen access

  Importance: For myopia control to be beneficial, it would be important that the benefit of treatment (slowed eye growth) is not lost because of faster than normal growth (rebound) after discontinuing treatment. Objective: To determine whether there is a loss of treatment effect (rebound) after discontinuing soft multifocal contact lenses in children with myopia. Design, Setting, and Participants: The Bifocal Lenses in Nearsighted Kids 2 (BLINK2) cohort study involved children with myopia (aged 11-17 years at BLINK2 baseline) who completed the BLINK Study randomized clinical trial. Enrollment was from September 2019 through January 2021; follow-up was completed in January 2024. In the BLINK2 Study, all children wore high-add (+2.50 diopter [D]) multifocal soft contact lenses for 2 years and single-vision soft contact lenses during the third year to determine if rebound occurred. Exposure: High-add multifocal soft contact lenses and single-vision soft contact lenses. Main Outcomes and Measures: Eye length (optical biometry) and refractive error (cycloplegic autorefraction) were measured annually. Results: Of 248 participants enrolled in BLINK2, 235 completed the study. The median age at the baseline visit was 15 years (range, 11-17 years); 146 participants (59%) were female, and 102 (41%) were male. At baseline for BLINK2, mean (SD) axial length and spherical equivalent refractive error were 25.2 (0.9) mm and -3.40 (1.40) D, respectively. After participants switched from multifocal to single-vision contact lenses, axial elongation increased by 0.03 mm per year (95% CI, 0.01 to 0.05) regardless of their original BLINK treatment assignment (P = .81). There was also an increase in myopia progression after switching to single-vision lenses of -0.17 D per year (95% CI, -0.22 to -0.12) that did not depend on the original BLINK treatment assignment (P = .57). There continued to be a difference in axial length and refractive error throughout BLINK2 based on the BLINK Study treatment assignment with the original high-add group having shorter eyes and less myopia than the original medium-add (+1.50 D) and single-vision groups. Conclusions and Relevance: The BLINK2 Study found no evidence of a loss of treatment effect after discontinuing multifocal contact lenses in older teenagers. These data suggest eye growth and myopia progression returned to faster but age-expected rates and support continuing multifocal lenses until cessation of elongation and progression.

  PublisherOA PDFDOI

• Long‐term test and retest reliability of clinical vergence testing

  Ophthalmic and Physiological Optics · 2025-10-06

  articleOpen accessCorresponding

  PURPOSE: To establish long-term reliability measures for vergence testing in a control population of adolescents. METHODS: Healthy participants between 12 and 17.5 years with normal binocular vision were recruited from 10 clinical sites. Cover test, near point of convergence (NPC), positive and negative fusional vergences, vergence facility (12∆ base-out/3∆ base-in) and vergence jumps (using the Oculomotor Assessment Tool) were performed at the initial visit and repeated at 90 days. The mean and standard deviation were calculated for the overall group for NPC, vergence facility and vergence jumps and by prism dioptre step value for PFV and NFV (1Δ or 2Δ if below 20∆ or 5Δ above 20∆). Agreement was assessed using Bland-Altman plots and 95% limits of agreement (LOA). RESULTS: Ninety-three participants (mean age 14.3 ± 1.7 years, 52% female) were enrolled and 91 (98%) completed the initial and 90-day outcome evaluation. The mean differences were significantly greater than zero for vergence facility (p < 0.05) and the first and second 30 s of vergence jumps (p < 0.01). The 95% LOA were narrow for NPC (±2.5) and negative fusional vergence (±5.9), suggesting good repeatability. LOA were larger for positive fusional vergence (±17.8), vergence facility (±9.8) and vergence jumps (±16.2). Analysis of the positive fusional vergence data indicates that the different step sizes (1∆ or 2∆ vs. 5∆) in the horizontal prism bar contribute to considerably larger variability in these measures. CONCLUSIONS: In participants with normal binocular vision and no concussion history, good reliability yielded comparable results 90 days apart for all vergence measures. The results provide values that can be used to interpret the effect of intervention for vergence disorders in clinical practice and research studies. An important outcome of this study is the understanding that 5∆ steps on the typical horizontal prism bar contribute to high variability in positive fusional vergence measures when findings are ≥20∆.

  PublisherOA PDFDOI

• Publisher Correction: Twelve month refractive and axial length changes in the Israeli refractive error, activity, and devices (iREAD) study

  Scientific Reports · 2025-07-10

  erratumOpen access
  PublisherOA PDFDOI

• Axial length as a function of age, sex, and ethnicity: Results from the CLEERE study

  Optometry and Vision Science · 2025-10-23 · 3 citations

  articleOpen access

  SIGNIFICANCE: Axial length is emerging as the primary outcome variable used for assessing myopia control efficacy, in both clinic and clinical trials. This report provides a model of axial length as a function of age, sex, and race/ethnicity, in addition to percentiles of axial length across age in childhood. PURPOSE: To model axial length in juvenile-onset myopia and children in general as a function of age, sex, race/ethnicity, parental history of myopia, diopter-hours of near work, and hours of outdoor/sports activities. METHODS: Axial length from the time of myopia onset was modeled using quadratic fits as a function of age, sex, race/ethnicity, and other covariates. Myopic participants were 590 children in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) study with at least three annual visits: one without myopia, an onset visit 1 year later (spherical equivalent at least -0.75 D), and another visit after myopia onset. Percentiles for axial length from the entire CLEERE sample were determined using 23,154 observations from 4877 children. RESULTS: Axial elongation in myopic children was greatest at younger ages, slowing with age in a quadratic trajectory between 6 and 14 years. The average rate of elongation at a given age, however, was independent of the age of myopia onset. In the general sample of children, axial length percentiles at age 6 years were similar across racial/ethnic groups, but Asian American children had the steepest increases in axial length with age, followed by Native American and Hispanic children. The shallowest increases occurred in Black and White children. Females had shorter axial lengths than males by 0.4 to 0.5 mm, but a higher probability of being myopic for a given age and axial length percentile. Parental history of myopia, time spent reading, and time spent in outdoor/sports activity were not significant factors for axial length in multivariate models. CONCLUSIONS: The models of axial length as a function of age, sex, and race/ethnicity, along with their percentiles, may prove useful in sample size planning for clinical trials, for judging efficacy of myopia control in individual children, and for comparison to more recent datasets.

  PublisherOA PDFDOI

• Frequency of retinal findings after 8 years in the Bifocal Lenses in Nearsighted Kids ( <scp>BLINK</scp> ) Study

  Ophthalmic and Physiological Optics · 2025-06-13

  articleOpen accessCorresponding

  PURPOSE: The purpose of the study is to report the frequency of retinal findings in myopic children and determine the association with the amount of myopia or axial length. DESIGN: The BLINK study was a myopia control, multi-centre randomised clinical trial following myopic children with multifocal soft contact lenses. PARTICIPANTS: Children aged 7-11 years with myopia (sphere) from -0.75 to -5.00 D and 1.00 D cylinder or less at baseline who completed the final BLINK2 study visit (n = 235). METHODS: Children had an annual dilated fundus examination. Retinal findings were classified into three main categories: vitreous, peripheral retina and other retinal findings, and further subdivided into 17 subcategories. MAIN OUTCOME MEASURES: Frequencies were calculated. Groups used median splits of spherical equivalent refractive error and axial length, and differences were assessed using chi-squared tests. Incidence was calculated. RESULTS: Overall, 186/235 (79.1%) participants had at least one retinal finding and 81/235 (34.5%) participants had at least one vitreous or peripheral retinal finding that could increase the risk of sight-threatening complications. One participant had a retinal detachment. The incidence of any retinal finding in those with no previous findings was 12.5/100 person-years (95% confidence interval = 10.2-15.0). Peripheral retinal finding incidence was 2.4/100 person-years (1.8-3.2), while the vitreous finding incidence was 1.7/100 person-years (1.2-2.4). At each dilated examination, at least 7.2% of participants had a newly documented finding. Sex, age, spherical equivalent refractive error and axial length were not associated with differences in findings (all p ≥ 0.08). CONCLUSION: Almost 80% of children with juvenile-onset myopia had a documented retinal finding, which was not associated with the amount of myopia or axial length. Almost 35% had a vitreous or peripheral retina finding that could increase the risk for potential sight-threatening complications, which warrants routine dilation and close follow-up to monitor for retinal changes.

  PublisherOA PDFDOI

• Predicting the onset of myopia in children by age, sex, and ethnicity: Results from the CLEERE Study

  Optometry and Vision Science · 2024-04-01 · 15 citations

  articleOpen access

  SIGNIFICANCE: Clinicians and researchers would benefit from being able to predict the onset of myopia for an individual child. This report provides a model for calculating the probability of myopia onset, year-by-year and cumulatively, based on results from the largest, most ethnically diverse study of myopia onset in the United States. PURPOSE: This study aimed to model the probability of the onset of myopia in previously nonmyopic school-aged children. METHODS: Children aged 6 years to less than 14 years of age at baseline participating in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study who were nonmyopic and less hyperopic than +3.00 D (spherical equivalent) were followed up for 1 to 7 years through eighth grade. Annual measurements included cycloplegic autorefraction, keratometry, ultrasound axial dimensions, and parental report of children's near work and time spent in outdoor and/or sports activities. The onset of myopia was defined as the first visit with at least -0.75 D of myopia in each principal meridian. The predictive model was built using discrete time survival analysis and evaluated with C statistics. RESULTS: The model of the probability of the onset of myopia included cycloplegic spherical equivalent refractive error, the horizontal/vertical component of astigmatism (J0), age, sex, and race/ethnicity. Onset of myopia was more likely with lower amounts of hyperopia and less positive/more negative values of J0. Younger Asian American females had the highest eventual probability of onset, whereas older White males had the lowest. Model performance increased with older baseline age, with C statistics ranging from 0.83 at 6 years of age to 0.92 at 13 years. CONCLUSIONS: The probability of the onset of myopia can be estimated for children in the major racial/ethnic groups within the United States on a year-by-year and cumulative basis up to age 14 years based on a simple set of refractive error and demographic variables.

  PublisherOA PDFDOI

• Peripheral Defocus, Pupil Size, and Axial Eye Growth in Children Wearing Soft Multifocal Contact Lenses in the BLINK Study

  Investigative Ophthalmology & Visual Science · 2023-11-01 · 16 citations

  articleOpen access

  Purpose: The purpose of this study was to evaluate the relationship between peripheral defocus and pupil size on axial growth in children randomly assigned to wear either single vision contact lenses, +1.50 diopter (D), or +2.50 D addition multifocal contact lenses (MFCLs). Methods: Children 7 to 11 years old with myopia (-0.75 to -5.00 D; spherical component) and ≤1.00 D astigmatism were enrolled. Autorefraction (horizontal meridian; right eye) was measured annually wearing contact lenses centrally and ±20 degrees, ±30 degrees, and ±40 degrees from the line of sight at near and distance. Photopic and mesopic pupil size were measured. The effects of peripheral defocus, treatment group, and pupil size on the 3-year change in axial length were modeled using multiple variables that evaluated defocus across the retina. Results: Although several peripheral defocus variables were associated with slower axial growth with MFCLs, they were either no longer significant or not meaningfully associated with eye growth after the treatment group was included in the model. The treatment group assignment better explained the slower eye growth with +2.50 MFCLs than peripheral defocus. Photopic and mesopic pupil size did not modify eye growth with the +2.50 MFCL (all P ≥ 0.37). Conclusions: The optical signal causing slower axial elongation with +2.50 MFCLs is better explained by the lens type worn than by peripheral defocus. The signal might be something other than peripheral defocus, or there is not a linear dose-response relationship within treatment groups. We found no evidence to support pupil size as a criterion when deciding which myopic children to treat with MFCLs.

  PublisherDOI

Recent grants

• Soft Bifocal Contact Lens Myopia Control - Data Coordinating Center

  NIH · $1.8M · 2014–2019

Frequent coauthors

• Justin Kwan

  93 shared

• Andrew D. Pucker

  University of Alabama at Birmingham

  93 shared

• Wolfgang Sickenberger

  89 shared

• Lyndon Jones

  University of Waterloo

  89 shared

• Sebastian Marx

  88 shared

• Donald O. Mutti

  81 shared

• Loraine T. Sinnott

  SUNY College of Optometry

  62 shared

• Sruthi Srinivasan

  Cooper University Hospital

  54 shared

Labs

• Karla Zadnik LabPI

Education

• Ph.D., Optometry

  The Ohio State University

  2005

• M.S., Optometry

  The Ohio State University

  2001

• B.S., Optometry

  The Ohio State University

  1998