Lubica Rauova
VerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 1993–2024
Research topics
- Medicine
- Immunology
- Internal medicine
Selected publications
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19
Frontiers in Immunology · 2022 · 54 citations
- Medicine
- Immunology
- Internal medicine
platelet activation. Mechanistically, blocking the signaling of the FcγRIIa-Syk and C5a-C5aR pathways on platelets, using antibody-mediated neutralization, IgG depletion or the Syk inhibitor fostamatinib, reversed this hyperactivity driven by COVID-19 plasma and prevented platelet aggregation in endothelial microfluidic chamber conditions. These data identified these potentially actionable pathways as central for platelet activation and/or vascular complications and clinical outcomes in COVID-19 patients. In conclusion, we reveal a key role of platelet-mediated immunothrombosis in COVID-19 and identify distinct, clinically relevant, targetable signaling pathways that mediate this effect.
Recent grants
NIH · $25.0M · 2017
Frequent coauthors
- 286 shared
Mortimer Poncz
Children's Hospital of Philadelphia
- 151 shared
Douglas B. Cines
University of Pennsylvania
- 111 shared
Gowthami M. Arepally
Duke Medical Center
- 81 shared
M. Anna Kowalska
Polish Academy of Sciences
- 40 shared
Amrita Sarkar
Children's Hospital of Philadelphia
- 40 shared
Steven E. McKenzie
Thomas Jefferson University
- 37 shared
John W. Weisel
University of Pennsylvania
- 37 shared
Bruce S. Sachais
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