About

Laura Niedernhofer, MD, PhD, joined the University of Minnesota in July 2018 to direct the Masonic Institute on the Biology of Aging and Metabolism (MiBAM) and the Medical Discovery Team on the Biology of Aging. She is a professor in the Department of Biochemistry, Molecular Biology and Biophysics. Her expertise is in DNA damage and repair, genome instability disorders, cellular senescence, and aging. Her research program is centered on studying fundamental mechanisms of aging and developing therapeutics to target them. Dr. Niedernhofer’s research involves implementing a murine model of a human progeroid syndrome caused by a defect in DNA repair, which provides insights into the impact of DNA damage on DNA structure, cell function, and organism health. She contributed to the discovery of a new class of drugs called senolytics. Her career includes serving on study sections for NCI, NIEHS, and NIA, and she has been recognized with awards for research in aging, cancer, and environmental health science.

Research topics

• Biology
• Cell biology
• Medicine
• Cancer research
• Genetics

Recent grants

• NIH Grant R03CA121411

  NIH · $146k · 2008

• NIH Grant K22CA111525

  NIH · $461k · 2008

• Administrative Supplement to: Cell Autonomous and Non-Autonomous Mechanisms of Aging

  NIH · $17.7M · 2019–2020

• Immune cells as a driver of cell non-autonomous aging

  NIH · $3.4M · 2019–2024

• Immune cells as a driver of cell non-autonomous aging

  NIH · $385k · 2018–2019

Frequent coauthors

• Paul D. Robbins

  University of Minnesota

  243 shared

• Matthew J. Yousefzadeh

  Institute on Aging

  102 shared

• Andria R. Robinson

  Università Cattolica del Sacro Cuore

  71 shared

• Luise Angelini

  University of Minnesota System

  50 shared

• Sara J. McGowan

  University of Minnesota System

  49 shared

• James L. Kirkland

  Mayo Clinic

  49 shared

• Erin A. Wade

  The Ohio State University Wexner Medical Center

  45 shared

• Kenneth H. Kraemer

  38 shared

Labs

• Niedernhofer LabPI

Education

• Post-doc, Genetics

  Erasmus University Medical Center

  2003

• M.D.

  Vanderbilt University School of Medicine

  1998

• Ph.D., Biochemistry

  Vanderbilt University School of Medicine

  1996

• M.S., Physiology Medicine

  Georgetown University School of Medicine

  1990

• B.S., Chemistry

  Duke University

  1985

Awards & honors

• Dr. James E. Rubin Medical Memorial Award
• Graduating Medical Student Research Award
• Veneziale-Steer Award
• Dr. Marvin and Hadassah Bacaner Research Awards
• Schmidt Steer Award

Similar researchers at University of Minnesota

• David Jacobsh-223
• Eamonn Maherh-172
• Robert Kruegerh-132
• Paul Robbinsh-126
• Matt McGueh-125