Michael Lee Kochman
VerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 1974–2025
About
Michael Lee Kochman, MD, is the Wilmott Family Professor and serves as the Director of Advanced Endoscopic Training at the Hospital of the University of Pennsylvania. He is also the Director of Endoscopy Training at the same hospital and leads the Center for Endoscopic Education, Innovation, and Training within the Departments of Medicine and Surgery at the University of Pennsylvania. His professional focus is on advanced endoscopic procedures, education, and training in gastroenterology. Dr. Kochman is a faculty member in the Department of Medicine at the Perelman School of Medicine, University of Pennsylvania, and has contributed extensively to the field through his leadership roles and educational initiatives.
Research topics
- Medicine
- Internal medicine
- Surgery
- Radiology
- General surgery
Selected publications
bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-03
preprintOpen accessAbstract An accumulating body of evidence suggests carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting homologous recombination to repair double-stranded DNA breaks. The aim of this investigation was to identify differences within the gastric epithelium and in patient-derived gastric organoids (PDGOs) between BRCA1 and BRCA2 carriers and non-carriers to determine if evidence of early gastric carcinogenesis exists amongst these carriers. First, using gastric epithelial biopsies, BRCA2 carriers were found to harbor higher expression of the proliferative marker Ki-67 within the antral gastric epithelium and strikingly, biopsies from both BRCA1 and BRCA2 carriers displayed a marked increase in double-stranded DNA damage. These results were further explored using PDGOs, where a growth advantage was observed for both BRCA1 and BRCA2 PDGOs compared to non-carrier PDGOs. Furthermore, both BRCA1 and BRCA2 PDGOs displayed a more pronounced enhancement of Ki-67 expression as well as increased double stranded DNA damage compared to non-carrier PDGOs. Importantly, none of the PDGOs showed signs of BRCA1 or BRCA2 loss of heterozygosity, potentially indicating a haploinsufficient phenotype. Taken together, these novel findings suggest that haploinsufficiency in BRCA1 and BRCA2 carriers may lead to DNA damage in the gastric epithelium, which may serve as an early event contributing to GC development.
Gastroenterology · 2025-05-01
articleSenior authorGastrointestinal Endoscopy · 2025-10-20 · 2 citations
articleOpen accessBACKGROUND AND AIMS: Piecemeal endoscopic mucosal resection (EMR) is the standard of care for large, nonpedunculated colon polyps but is associated with recurrence rates of 9% to 31%. Current guidelines recommend 6-month surveillance for all patients, although this may not be necessary for lower-risk cases. METHODS: We retrospectively reviewed patients who underwent piecemeal EMR of ≥20-mm colon polyps between 2018 and 2021. Patients were stratified into 6- or 12-month surveillance groups based on polyp features. Recurrence rates and associated factors were compared. RESULTS: Among 193 patients, recurrence was higher in the 6-month (31.5%) than in the 12-month group (14.3%, P < .05). Among patients with recurrence, the 6-month follow-up group had more tubulovillous adenomas (P < .05) on index colonoscopy. Tubulovillous histology in the initial polyp was the only factor associated with recurrence. CONCLUSIONS: A risk-stratified approach may safely extend surveillance to 12 months for lower-risk patients after piecemeal EMR, reducing unnecessary procedures without compromising care.
Clinical Gastroenterology and Hepatology · 2025-01-30
letterGastroenterology · 2024-05-01
articleGastrointestinal Endoscopy · 2024-06-01
articleSenior authorGastroenterology · 2024-05-01
articleOUTPATIENT DIRECT DIVERTICULOTOMY OF ZENKER’S DIVERTICULUM IS SAFE AND EFFECTIVE
Gastrointestinal Endoscopy · 2024-06-01
articleSenior authorSINGLE CENTER RETROSPECTIVE STUDY COMPARING Z-POEM AND FEIT-Z IN PATIENTS WITH ZENKER’S DIVERTICULUM
Gastrointestinal Endoscopy · 2024-06-01
articleSenior authorCancer Prevention Research · 2024-04-19
articleOpen accessBRCA1 and BRCA2 carriers may be at increased risk for gastric cancer; however, the mechanisms of gastric carcinogenesis remain poorly understood. We sought to determine the prevalence of gastric cancer risk factors Helicobacter pylori (H. pylori) infection and gastric intestinal metaplasia (GIM) among BRCA1/2 carriers to gain insight into the pathogenesis of gastric cancer in this population. A total of 100 unselected BRCA1/2 carriers who underwent endoscopic ultrasound from March 2022 to March 2023 underwent concomitant upper endoscopy with nontargeted gastric antrum and body biopsies. The study population (70% women; mean age 60.1 years) included 66% BRCA2 carriers. H. pylori was detected in one (1%) individual, 7 (7%) had GIM, 2 (2%) had autoimmune atrophic gastritis, and no gastric cancers were diagnosed. Among BRCA1/2 carriers, H. pylori prevalence was low and GIM prevalence was similar to that in the general population; however, identification of H. pylori or GIM may help inform future gastric cancer risk management strategies in BRCA1/2 carriers. Prevention Relevance: Evaluating the burden of H. pylori infection and GIM among BRCA1/2 carriers is warranted to better understand the mechanisms of gastric carcinogenesis and to help inform risk management strategies for gastric cancer among this at-risk population.
Frequent coauthors
- 223 shared
Jacques Van Dam
- 197 shared
Gregory G. Ginsberg
- 129 shared
Douglas O. Faigel
- 129 shared
Thomas J. Savides
University of California, San Diego
- 126 shared
Todd H. Baron
- 126 shared
Grace H. Elta
Michigan Medicine
- 125 shared
James M. Scheiman
University of Michigan–Ann Arbor
- 123 shared
Kenneth R. McQuaid
San Francisco VA Health Care System
Labs
Kochman LaboratoryPI
Education
- 1986
MD
University of Illinois at Chicago College of Medicine
- 1982
BA, Economics
Northwestern University
Awards & honors
- Wilmott Family Professor
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