About

Dr. Claudio Guerrieri is a pathologist affiliated with Rutgers New Jersey Medical School, Department of Pathology, Immunology and Laboratory Medicine. He received his medical degree from Sapienza University of Rome in 1981 and has been practicing for more than 20 years. His professional practice includes affiliations with multiple hospitals in Brooklyn, New York, including Newark Beth Israel Medical Center and Phelps Memorial Hospital Center. His work involves clinical pathology, with a focus on diagnostic practices, and he has contributed to medical literature through publications on various pathological cases, including intracystic papillary carcinoma, rhabdomyosarcoma of the hand metastasizing to the breast, and undifferentiated embryonal sarcoma of the liver.

Research topics

• Biology
• Medicine
• Pathology
• Internal medicine
• Endocrinology

Selected publications

• Pulmonary squamous cell carcinoma with a lepidic-pagetoid growth pattern

  Pathologica · 2022-09-01 · 6 citations

  articleOpen access1st authorCorresponding

  We report a rare case of a peripheral squamous cell carcinoma (SCC) of the lung in which most of the tumor displayed a "lepidic" growth pattern. The tumor cells also appeared to grow along the alveolar walls between the overlying pneumocytes and underlying basement membrane, a form reminiscent of the "pagetoid" mode of spread. The neoplastic cells were positive for the squamous markers p63 and p40. TTF-1 and CK7 highlighted residual non-neoplastic pneumocytes, which either covered the lepidic tumor cells or lined pseudoglandular formations created by the filling of alveolar spaces by the tumor. CK7 also stained the tumor cells, albeit focally and weakly, a not uncommon finding in peripheral lung SCC. The tumor cells were negative for TTF-1 (clone 8G7G3/1), but did show focal weak reactivity with the less specific clone SPT24. The invasive area measured 2.5 mm while the overall size of the tumor including the lepidic-pagetoid component was 9.0 mm. Even though the invasive component was < 0.5 cm, the only option according to existing staging criteria was to stage it as pT1a. Since the current staging system does not account for the non-invasive lepidic component of pulmonary SCC, the increasing awareness of this variant may require its inclusion within the classification and pathological staging of lung carcinoma.

  PublisherOA PDFDOI

• Reinterpretare il fatto religioso come azione dei cristiani nella storia: Dietrich Bonhoeffer e Chiara Lubich

  Salesianum · 2022-01-01

  article1st authorCorresponding

  Nella consapevolezza che una ermeneutica della religione è attenta all’interpretazione che anima l’esperienza religiosa nei suoi attori e che l’esperienza cristiana si è caratterizzata come una interpretazione degli eventi storici e come un impegno a dare un contributo non solo nell’ambito della religione e delle sue pratiche, si rileggono alcune pagine del pensiero di Bonhoeffer mettendole in relazione con quelle della Lubich. In questo confronto si tiene conto della vicinanza storica e della differenza di condizioni ed età con cui si affronta quel momento storico. Per entrambi il messaggio evangelico interpella i cristiani ad agire personalmente e comunitariamente. Si cercherà di evidenziare nuclei comuni tra le due prospettive e gli sviluppi che vanno in direzioni diverse.

  PublisherDOI

• Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

  International Journal of Gynecological Pathology · 2022 · 4 citations

  1st authorCorresponding
  • Pathology
  • Biology
  • Medicine

  We report a case of a cystic ovarian neoplasm in a 76-yr-old female composed of 2 distinct and intimately associated components: a macrocystic adult granulosa cell tumor (AGCT) and a serous borderline tumor. The granulosa cell nature of the tumor was confirmed with positive immunohistochemical staining for inhibin, calretinin, and WT1, while the neoplastic nature of the granulosa cell proliferation was supported by the presence of a point mutation of the FOXL2 gene. A review of 19 previously reported mixed AGCT and epithelial neoplasms of the ovary is included. Of the eight mixed AGCT and epithelial tumors, including our case, that were tested for FOXL2 mutation, 4 of the 5 mutation-positive cases were notable for demonstrating a macroscopically visible nodule or mass of AGCT at the time of gross examination, while 2 of the 3 mutation-negative cases lacked a mass-producing granulosa cell component. This feature by itself may be sufficient to predict the true neoplastic nature of the granulosa cell proliferation. This is the first reported case of a composite neoplastic AGCT and serous borderline tumor. We also discuss the current histogenetic models for these rare mixed AGCT and epithelial tumors.

  PublisherDOI

• Pagetoid involvement of bronchioles by metastatic breast carcinoma

  Pathologica · 2021-04-01 · 1 citations

  articleOpen access1st authorCorresponding

  We report a case of a 36-year-old female with endobronchiolar spread of breast carcinoma in the lung. The patient had recently been diagnosed with invasive ductal breast carcinoma and imaging of the lungs revealed bilateral lung nodules. She then underwent a wedge resection of a lung nodule. The biopsy revealed a subpleural metastatic nodule of invasive ductal carcinoma with an intra-alveolar pattern of spread at its advancing edge. Several smaller foci of intra-alveolar tumor were noted as well as pagetoid spread of tumor cells along a 0.9 mm wide bronchiole. The neoplastic cells were TTF-1 negative, GATA3 positive and ER positive. This is the third reported case of pagetoid spread of metastatic breast carcinoma along the bronchial tree. This case emphasizes the importance of examining not only bronchi but also bronchioles to detect this unusual pattern of spread of metastatic breast carcinoma in lung resection specimens.

  PublisherOA PDFDOI

• A rare case of angiomyomatous hamartoma of periaortic lymph node and synchronous angiomyolipoma of the kidney: a diagnostic pitfall for lymph node involvement by angiomyolipoma

  Human Pathology Case Reports · 2020-02-27 · 3 citations

  articleOpen access

  Angiomyomatous hamartoma is a rare benign proliferative lesion of lymph nodes, showing replacement of the lymph node parenchyma by irregular thick-walled blood vessels, smooth muscle, fibrotic stroma and variable amount of adipose tissue. These histologic features greatly overlap with those described in angiomyolipoma, a member of the perivascular epithelioid cell tumor (PEComa) family. We present a unique case of angiomyomatous hamartoma of a periaortic lymph node, which mimicked lymph node involvement in a patient with renal angiomyolipoma on hematoxylin and eosin (H&E) stained slides alone. Keywords: Renal angiomyolipoma, Angiomyomatous hamartoma, Periaortic lymph node, Angiomyolipoma in lymph node, Melanocytic immunomarkers, Cathepsin K

  PublisherDOI

• Vaping associated lung illness: a case series

  Current Challenges in Thoracic Surgery · 2020-03-11

  articleOpen access

  Abstract: Electronic cigarette (e-cigarette) use, also known as vaping, has gained popularity among young adults. It has been promoted as a safer alternative to conventional cigarette smoking. Recent reports, however, have linked e-cigarette use to lung dysfunction. We report a series of four patients who were recently treated within our hospital system for vaping associated lung illness (VALI). All four were young, healthy individuals with no significant past medical histories. Lung biopsies were performed on three of these patients and the results are reviewed in the article. All patients were treated with high dose steroids once cultures were finalized and no infectious etiology was detected. Recovery of lung function was seen after treatment in all cases.

  PublisherOA PDFDOI

• Ciliated Carcinoma of the Endometrium

  International Journal of Gynecological Pathology · 2020 · 5 citations

  1st authorCorresponding
  • Pathology
  • Medicine
  • Biology

  We report a case of ciliated carcinoma of the endometrium in a 55-yr-old woman with stromal hyperthecosis of the ovaries. The patient presented with postmenopausal uterine bleeding and an endometrial curetting revealed an atypical epithelial proliferation that met the criteria for endometrioid adenocarcinoma notwithstanding an abundance of ciliated cells. Cilia were present not only within typical endometrioid glands but also within microacini of quasi-solid areas as well as inside intracytoplasmic vacuoles. The subsequent hysterectomy specimen demonstrated a well-differentiated adenocarcinoma of the endometrium with a predominance of neoplastic glands lined by ciliated epithelial cells, thus confirming the initial suspicion for ciliated carcinoma. Since the first description of ciliated adenocarcinoma of the endometrium in 1983, only a handful of additional cases have been reported in the literature. We review the spectrum of histologic presentations of this endometrial neoplasm and elaborate on its distinction from cilia-bearing mimickers and its histogenesis.

  PublisherDOI

• Vaping Associated Lung Illness: A Case Series

  International Journal of Respiratory and Pulmonary Medicine · 2020-01-25

  articleOpen access

  Electronic cigarette (e-cigarette) use, also known as vaping, has gained popularity among young adults. It has been promoted as a safer alternative to conventional cigarette smoking. Recent reports, however, have linked e-cigarette use to lung dysfunction. We report a series of four patients who were recently treated within our hospital system for vaping associated lung illness (VALI). All four were young, healthy individuals with no significant past medical histories. Lung biopsies were performed on three of these patients and the results are reviewed in the article. All patients were treated with high dose steroids once cultures were finalized and no infectious etiology was detected. Recovery of lung function was seen after treatment in all cases.

  PublisherOA PDFDOI

• Perineal Clear Cell Hidradenoma: A GATA3-positive Neoplasm With Potential for Misdiagnosis

  International Journal of Gynecological Pathology · 2020-09-11 · 4 citations

  articleSenior author

  We report a case of clear cell hidradenoma of the perineum that was initially misinterpreted as a papillary urothelial carcinoma, either metastatic or of Bartholin gland origin, on initial excisional biopsy. The misinterpretation may have been due to the pseudopapillary architecture and GATA3-positivity of the biopsy tissue. Clear cell hidradenomas often show a range of histologic growth patterns and cellular differentiation and are one of many tumors that react immunohistochemically with GATA3. Although rare, these tumors can occur in the genital region and can mimic malignant tumors such as metastatic renal cell carcinoma and carcinomas of the genitourinary tract. This report details the morphologic and immunohistochemical pitfalls that make accurate diagnosis of clear cell hidradenoma in this unusual location challenging.

  PublisherDOI

• Autonomia e relazione di filosofia e teologia in Klaus Hemmerle

  Salesianum · 2020-09-01

  article1st authorCorresponding

  L’articolo offre una lettura ermeneutica del pensiero di K. Hemmerle, mettendo in luce la reciproca apertura tra rivelazione e ricerca razionale, il radicamento del pensare nel vissuto, relazionale e religioso. Si analizzano i rapporti tra verità, testimonianza e interpretazione della verità, confrontando la ricerca di Hemmerle con le speculazioni di H. Gadamer e L. Pareyson, e si evidenzia come tali percorsi approdino alla ‘conversazione’, al ‘dialogo’. In Hemmerle autonomia e relazione tra teologia e filosofia si attuano perché, se la filosofia parte “da noi” e la teologia dall’abbandonarsi alla rivelazione di Dio nel Cristo, con l’“ecce homo” avviene un “ecce philosophia”. La filosofia è in gioco sin dall’inizio nel messaggio cristiano e prendendo sul serio la rivelazione si aprono nuovi orizzonti al pensare e la possibilità di una nuova ontologia relazionale. Un nuovo fondamento per la teologia e la filosofia, una nuova possibile conversazione tra io e tu nel noi.

  PublisherDOI

Frequent coauthors

• Rachel Hudacko

  Newark Beth Israel Medical Center

  84 shared

• Patrick Anderson

  University of Ottawa

  41 shared

• Patrick Anderson

  16 shared

• Eddy M. Joseph

  Rutgers, The State University of New Jersey

  12 shared

• Larry Shemen

  Cornell University

  8 shared

• Fred B. Smith

  Saint Vincent's Catholic Medical Center

  8 shared

• Sabiha Hussain

  Rutgers, The State University of New Jersey

  8 shared

• Sherif S. Ismail

  Catholic Medical Center

  8 shared

Education

• M.D.

  University of Rome 'La Sapienza'

  1981