About

Mark A. Kasevich is a faculty member at Stanford University, associated with the Department of Applied Physics. His research interests include nanoscience and quantum engineering, with a focus on quantum metrology and atom interferometry. He works on the development and application of ultrastable lasers, ultrafast electron sources, and explores quantum simulation with atomic systems within condensed matter physics. His work contributes to advancing understanding and technology in these areas, leveraging his expertise in lasers, accelerators, and quantum systems.

Research topics

• Data Mining
• Physics
• Computer Science
• Quantum mechanics
• Algorithm
• Optics
• Astronomy
• Astrophysics
• Mathematics
• Discrete mathematics

Selected publications

• Fast wide-field light sheet electro-optic FLIM

  Optics Express · 2026-02-03

  preprintOpen accessSenior author

  We demonstrate volumetric fluorescence lifetime microscopy (FLIM) using the electro-optic FLIM technique. Images acquired in a selective plane illumination microscope are gated using a Pockels cell driven at 80 MHz, enabling light sheet electro-optic FLIM (LS-EO-FLIM) acquisition with up to 800 μ m field of view. Volume acquisitions are demonstrated on fluorescent bead mixtures and in live Arabidopsis thaliana root samples using both genetically encoded fluorescent proteins and endogenous autofluorescence.

  PublisherDOI

• Engineering a Sr cavity platform for fast, three-photon clock state control and robust, spin-squeezed sensors

  2026-03-05

  article1st authorCorresponding
  PublisherDOI

• Fast wide-field light sheet electro-optic FLIM

  Optics Express · 2026-02-03

  articleOpen accessSenior author

  We demonstrate volumetric fluorescence lifetime microscopy (FLIM) using the electro-optic FLIM technique. Images acquired in a selective plane illumination microscope are gated using a Pockels cell driven at 80 MHz, enabling light sheet electro-optic FLIM (LS-EO-FLIM) acquisition with up to 800 μ m field of view. Volume acquisitions are demonstrated on fluorescent bead mixtures and in live Arabidopsis thaliana root samples using both genetically encoded fluorescent proteins and endogenous autofluorescence.

  PublisherDOI

• Transverse mode control for atom interferometry

  2026-03-05

  article1st authorCorresponding
  PublisherDOI

• MAGIS-100 Experiment Facts

  2025-06-05

  reportOpen access
  PublisherOA PDFDOI

• Doppler-free three-photon spectroscopy on narrow-line optical transitions

  Physical review. A/Physical review, A · 2025-03-17 · 3 citations

  articleSenior author

  We demonstrate coherent Doppler-free three-photon excitation of the $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{0}$ optical clock transition and the $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{1}$ intercombination transition in free-space thermal clouds of $^{88}\mathrm{Sr}$ atoms. By appropriate orientation of the wave vectors of three lasers incident on the atoms, the first-order Doppler shift can be eliminated for all velocity classes. Three-photon excitation of the $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{1}$ transition enables high-contrast Ramsey spectroscopy with interrogation times comparable to the $21\phantom{\rule{0.16em}{0ex}}\textmu{}\mathrm{s}$ natural lifetime using a single near-resonant laser source. Three-photon spectroscopy on the $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{0}$ clock transition, using only laser frequencies nearly resonant with the $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{0}$ and $^{1}S_{0}\phantom{\rule{0.16em}{0ex}}\ensuremath{\leftrightarrow}\phantom{\rule{0.16em}{0ex}}^{3}P_{1}$ transitions, enables a reduction in Doppler broadening by two orders of magnitude and a corresponding $\ensuremath{\sim}470\phantom{\rule{0.16em}{0ex}}\mathrm{Hz}$ linewidth without a confining potential.

  PublisherDOI

• Quantum-optimal nonlinear microscopy with classical light

  ArXiv.org · 2025-12-03

  preprintOpen accessSenior author

  Nonlinear optical processes are used in biological microscopy to surpass the diffraction limit on resolution, image deeper into brain tissues, and identify biomolecules without exogenous labels. These techniques typically require high optical intensities to increase the strength of the nonlinear interactions, which can perturb native biochemistry and damage or kill living samples. Stimulated Raman scattering (SRS) microscopy visualizes the spatial distribution of molecules using a nonlinear interaction between light and chemically specific molecular vibrations. However, the detection of biomolecules at low concentrations is limited by the total photon dose that can be applied before photodamage alters the sample, and photon shot noise sets the minimum achievable noise floor for most microscopes. Here we demonstrate a cavity-enhanced SRS microscope that is more sensitive than an equivalent conventional SRS microscope by up to 8.3(7) dB in spectroscopy and 8.6(1) dB in cell imaging. These results approach quantum limits on sensitivity and demonstrate that quantum states of light are sufficient but not necessary to enhance the sensitivity of microscopy techniques that are limited by photodamage.

  PublisherOA PDFDOI

• Magnetic resonance control of reaction yields through genetically-encoded protein:flavin spin-correlated radicals in a live animal

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-03-03 · 10 citations

  preprintOpen accessSenior author

  Radio-frequency (RF) magnetic fields can influence reactions involving spin-correlated radical pairs. This provides a mechanism by which RF fields can influence living systems at the biomolecular level. Here we report the modification of the emission of various red fluorescent proteins (RFPs), in the presence of a flavin cofactor, induced by a combination of static and RF magnetic fields. Resonance features in the protein fluorescence intensity were observed near the electron spin resonance frequency at the corresponding static magnetic field strength. This effect was measured at room temperature both in vitro and in the nematode C. elegans , genetically modified to express the RFP mScarlet. These observations suggest that the magnetic field effects measured in RFP-flavin systems are due to quantum-correlated radical pairs. Our experiments demonstrate that RF magnetic fields can influence dynamics of reactions involving RFPs in biologically relevant conditions, and even within a living animal. These results have implications for the development of a new class of genetic tools based on RF manipulation of genetically-encoded quantum systems.

  PublisherOA PDFDOI

• MAGIS-100 Experiment Installation in Shaft

  2025-06-05

  reportOpen access
  PublisherOA PDFDOI

• 3 photon Doppler-free excitation of atomic Sr

  2024-03-12

  article1st authorCorresponding
  PublisherDOI

Recent grants

• Atom Interferometery

  NSF · $286k · 2003–2006

Frequent coauthors

• Jason M. Hogan

  Stanford University

  49 shared

• Brannon B. Klopfer

  Stanford University

  48 shared

• Thomas Juffmann

  40 shared

• Tim Kovachy

  Quantum Group (United States)

  28 shared

• Peter Asenbaum

  24 shared

• Chris Overstreet

  24 shared

• Peter W. Graham

  Kavli Institute for Particle Astrophysics and Cosmology

  22 shared

• Stewart A. Koppell

  21 shared

Labs

• Mark A. Kasevich's LabPI

  Not provided

Education

• Ph.D., Applied Physics

  Stanford University

  1992

• B.S., Physics

  University of California, Berkeley

  1987