About

V. Ramesh Iyer, M.D., M.B.B.S., is a Professor of Clinical Pediatrics (Cardiology) and an Attending Electrophysiologist in the Division of Cardiology at Children’s Hospital of Philadelphia. His educational background includes a B.Sc. from Hindu College, New Delhi, India, an MBBS from Maulana Azad Medical College, University of Delhi, an MD in Pediatrics from Safdarjang Hospital, and an MRCP in Pediatric and Neonatology residency from Royal College of Physicians, Edinburgh. He also holds a Master in Law from the University of Pennsylvania. His research expertise focuses on calcium signaling and electron microscopy in cardiac muscle ultrastructure in disease states such as hypertrophic cardiomyopathy and inherited ventricular tachycardias. He is involved in studying calcium release unit ultrastructure and modeling for sinus node functioning. His clinical expertise includes improving outcomes and reducing costs and fluoroscopy in patients undergoing complex ablations, as well as reducing time in ventricular fibrillation for ICD testing during initial implantation.

Research topics

• Medicine
• Internal medicine
• Cardiology
• Pediatrics
• Biophysics

Selected publications

• PO-02-205 NOVEL TREATMENT OF BRUGADA SYNDROME PRESENTING IN INFANCY WITH MALIGNANT VT

  Heart Rhythm · 2026-04-01

  article
  PublisherDOI

• PO-01-022 DEEP DIVE INTO ELECTROMAGNETIC INTERFERENCE (EMI) : THE IMPACT OF UNGROUNDED SWIMMING POOLS ON CARDIAC IMPLANTABLE ELECTRONIC DEVICES (CIED) IN CHILDREN

  Heart Rhythm · 2025-04-01

  article
  PublisherDOI

• PO-01-025 CHOOSING THE BEST OPTION FOR REMOTE MONITORING COMPLIANCE IN CHILDREN WITH CARDIAC IMPLANTABLE ELECTRONIC DEVICES

  Heart Rhythm · 2025-04-01

  article
  PublisherDOI

• PE-499654-002 ONE ALGORITHM TO RULE THEM ALL?: A DEEP NEURAL NETWORK FOR ATRIOVENTRICULAR ACCESSORY PATHWAY LOCALIZATION FROM RESTING ECG IN CHILDREN WITH WPW

  Heart Rhythm · 2025-04-01

  articleOpen access
  PublisherOA PDFDOI

• PO-01-154 NOVEL MECHANISM OF INAPPROPRIATE S-ICD SHOCK FOLLOWING SEPTAL MYECTOMY IN A PEDIATRIC PATIENT WITH HYPERTROPHIC CARDIOMYOPATHY

  Heart Rhythm · 2025-04-01

  article
  PublisherDOI

• PO-04-020 CHARACTERISTICS AND OUTCOMES OF PEDIATRIC PATIENTS UNDERGOING SUBCUTANEOUS ICD IMPLANTATION – AN ANALYSIS OF THE NCDR EP DEVICE IMPLANT REGISTRY

  Heart Rhythm · 2024-05-01

  articleOpen access
  PublisherOA PDFDOI

• PO-04-028 PERMANENT LEFT BUNDLE BRANCH AREA PACING IN CHILDREN: PRELIMINARY RESULTS ON FEASIBILITY, SAFETY AND EFFICACY

  Heart Rhythm · 2024-05-01

  article
  PublisherDOI

• “But for the blind spot”: Accuracy and diagnostic performance of smart watch cardiac features in pediatric patients

  Heart Rhythm · 2024-01-21 · 8 citations

  article
  PublisherDOI

• Abstract 4125701: Race and Ethnicity Are Associated with Diagnosis and Management of Wolff-Parkinson-White Pattern in Children

  Circulation · 2024-11-12

  article

  Background: Racial and ethnic disparities have been reported in catheter ablation in adults. There are limited data on the impact of race/ethnicity on the diagnosis and management of children with Wolff-Parkinson-White pattern (WPW). Hypothesis: Diagnosis of WPW by electrocardiogram (ECG) and risk stratification by exercise stress test (EST) and electrophysiology study (EPS) will differ by race/ethnicity in children. Methods: We performed a retrospective cohort study of patients 0-21 years old, excluding those with congenital heart disease, at a children’s hospital from 1991-2021. The primary exposure was race/ethnicity. Outcomes were 1) diagnosis of WPW on ECG, 2) undergoing EST, and 3) undergoing EPS. Likelihood and time to outcome were assessed with multivariable logistic regression adjusted for birth year and Cox regression, respectively. Results: The cohort consisted of 1,638,746 patients (White 53.0%, Black 21.0%, Hispanic 6.8%, Asian 4.2%, Multi-racial 2.0%, Other 11.0%, and Missing 1.7%). WPW was diagnosed in 898 patients (0.05%). After adjusting for birth year, Asian, Black, and Other race were associated with lower odds of WPW diagnosis compared to White patients (OR 0.57, 0.66, 0.70; p≤0.01). There was no association between race and age at first diagnosis (p=0.2). A total of 616 WPW patients (69%) underwent EST. Compared with White patients, Asian, Hispanic, and Other race were less likely to undergo EST (OR 0.39, 0.59, 0.62; p≤0.04), and those who did had their EST at later ages (HR 0.59, 0.65, 0.46; p≤0.04). A total of 739 WPW patients (82%) underwent EPS. Compared with White patients, Black, Hispanic, and Other race were less likely to undergo EPS (OR 0.44, 0.53, 0.59; p≤0.02), and those who did had their EPS at later ages (HR 0.60, 0.63, 0.66; p≤0.004). Conclusion: This analysis found that non-White racial and ethnic groups are less likely to be diagnosed with WPW. This may reflect differences in WPW prevalence by race/ethnicity, but differential access to ECG cannot be ruled out. Among WPW patients, however, Asian and Hispanic patients are approximately half as likely to undergo EST, while Black and Hispanic patients are approximately half as likely to undergo EPS, compared to White patients.

  PublisherDOI

• Risk Stratification in Pediatric Wolff-Parkinson-White: Practice Variation Among Pediatric Cardiologists and Electrophysiologists

  Pediatric Cardiology · 2023-08-06 · 6 citations

  article
  PublisherDOI

Frequent coauthors

• Victoria L. Vetter

  Children's Hospital of Philadelphia

  51 shared

• Maully J. Shah

  Children's Hospital of Philadelphia

  34 shared

• Christopher M. Janson

  Children's Hospital of Philadelphia

  31 shared

• Noreen P. Dugan

  20 shared

• R. Lee Vogel

  University of Pennsylvania

  18 shared

• Michael L. O’Byrne

  Children's Hospital of Philadelphia

  16 shared

• Justine Shults

  Children's Hospital of Philadelphia

  13 shared

• Clara Franzini‐Armstrong

  University of Pennsylvania

  12 shared