Endoscopic Submucosal Dissection (ESD) for Esophageal Cancer

2026-01-01

Clinical Validation of a Simulation-Based Mastery Learning Curriculum for Colonoscopy and Polypectomy in Practicing Gastroenterologists

Gastroenterology · 2026-03-10

POEM

2026-01-01

Endoscopic Submucosal Dissection (ESD) in Gastric Cancer

2026-01-01

Integrating multi-omics in bile for biomarker discovery in cholangiocarcinoma

Hepatology Communications · 2025-08-26 · 2 citations

BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive cancer with a poor prognosis. Histopathology evaluation of brushings and biopsies obtained during endoscopic retrograde cholangiopancreatography (ERCP) currently remains the main method of diagnosis, which has limited sensitivity for malignancy detection. Our study aimed to identify human bile-derived biomarkers to improve CCA diagnosis. Bile samples were collected from patients during ERCP for primary sclerosing cholangitis, CCA, or benign biliary disease. METHODS: Bile samples were collected from patients undergoing ERCP for biliary obstruction due to primary sclerosing cholangitis, newly identified malignant strictures concerning for CCA, or benign biliary disease. Using 16S sequencing, metabolomics, and bile acid quantification, we aimed to identify distinctive microbial and metabolite signatures associated with CCA. RESULTS: Multi-omics analyses revealed distinct microbial and metabolite signatures associated with CCA. From these findings, we identified and validated microbial and metabolite markers capable of accurately detecting CCA with improved sensitivity and specificity for malignancy detection compared to current cytology-based methods. CONCLUSIONS: These findings highlight the potential of multi-omics bile-based diagnostic panels to enhance endoscopic detection of biliary malignancies, offering a promising tool for evaluating indeterminate biliary strictures and advancing precision in ERCP diagnostics.

Clinical outcomes of endoscopic submucosal dissection for residual neoplasia after incomplete resection of large nonpedunculated colorectal polyps: a large multicenter propensity match study (with video)

Gastrointestinal Endoscopy · 2025-07-22 · 2 citations

CLINICAL FEASIBILITY AND SYSTEM-WIDE BENEFIT OF SAME DAY DISCHARGE IN THIRD SPACE ENDOSCOPY

Gastrointestinal Endoscopy · 2025-05-01

FACTORS ASSOCIATED WITH THE NEED FOR RESCURE LATERAL MYOTOMY DURING POEM

Gastrointestinal Endoscopy · 2025-05-01

ENDOSCOPIC SUBMUCOSAL DISSECTION AS SALVAGE THERAPY AFTER FAILED ENDOSCOPIC MUCOSAL RESECTION OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS: A LARGE MULTICENTER PROPENSITY MATCHED SCORE ANALYSIS

Gastrointestinal Endoscopy · 2025-05-01 · 1 citations

Abstract No. 14 Combined Percutaneous Endobiliary Radiofrequency Ablation and Prolonged Dilatation in Managing Refractory Benign Biliary Strictures: An Alternative to Long-Term Drainage

Journal of Vascular and Interventional Radiology · 2025-02-19