About

Andrea Kelly, M.D., M.S.C.E., is a Professor of Pediatrics specializing in Endocrinology and Diabetes at the Children's Hospital of Philadelphia. She holds the position of Attending Physician at the same hospital and is a faculty member at the Cystic Fibrosis Center. Dr. Kelly serves as the Associate Director of the Center for Human Phenomic Science and is the Director of Research for the Division of Endocrinology & Diabetes at Children's Hospital of Philadelphia, affiliated with the University of Pennsylvania. Her educational background includes a B.A. in Biology from LaSalle University, an M.D. from Jefferson Medical College, and an M.S.C.E. in Biostatistics and Epidemiology from the University of Pennsylvania School of Medicine. Her research focuses on pediatric endocrinology, including body composition, metabolic bone disease, and genetic factors affecting bone health in children.

Research topics

• Medicine
• Internal medicine
• Anesthesia
• Physical therapy
• Biology
• Biochemistry
• Genetics
• Bioinformatics
• Emergency medicine
• Microbiology
• Intensive care medicine

Selected publications

• Clinical Presentation and Outcomes of Insulinomas in Pediatric Patients

  Hormone Research in Paediatrics · 2026-05-18

  articleOpen access

  INTRODUCTION: Insulinomas are the leading cause of hyperinsulinemic hypoglycemia in adults, but they can also present during childhood, and, when they do, diagnosis and localization of the lesion can be difficult. Moreover, differentiating between congenital hyperinsulinism (HI) and pediatric insulinomas is challenging because both diseases have similar presentation. Our objective was to review the clinical presentation, diagnostic characteristics, and success of methods for localization, treatment, and outcomes in pediatric patients with insulinomas. METHODS: Retrospective study of patients with confirmed insulinoma treated at a single academic pediatric hospital between 2006 and 2024. Descriptive statistics and logistic regression models were used to quantify the data and discriminate between groups, respectively. The optimal operating point (OOP) for diagnostic laboratory data was used to maximize discrimination between insulinomas and congenital hyperinsulinism (HI), with prediction accuracy determined by the sensitivity and specificity at the OOP. RESULTS: We reviewed the records of 23 patients with insulinoma with a median age at presentation of 13 years. A positive family history of multiple endocrine neoplasia type 1 (MEN1) was recorded in 22%. The most common presenting symptom was altered mental status. Median plasma insulin and beta-hydroxybutyrate (BOHB) concentrations during hypoglycemia were 8.8 uIU/mL (61.1 pmol/L) and 0.3 mmol/L, respectively. Most patients had four imaging studies completed to localize their insulinoma. Twenty of the 23 patients reviewed had a single lesion successfully resected and were cured. Of these 20 patients, 12 had 18F-Fluoro-dihydroxyphenylalanine (18F-DOPA) positron emission tomography/computed tomography (PET/CT) completed, of which nine were positive (75%). Three patients had initial lesions localized and successfully resected but continued to have hypoglycemia requiring medical management. Median duration from presentation to surgery was 9 weeks. When comparing the critical samples of patients with insulinomas and HI, the combination of BOHB and insulin-like growth factor binding protein 1 (IGFBP-1) at the time of hypoglycemia yielded a sensitivity and specificity of 0.89 and 0.84, respectively, for insulinoma versus HI when using a multivariate function on our cohorts. CONCLUSION: In this series, successful treatment of insulinomas took, on average, 9 weeks from diagnosis. Multiple imaging modalities were employed for preoperative lesion localization, with 18F-DOPA PET/CT and MRI being the most successful. Improved imaging modalities are needed to localize insulinomas in pediatric patients and reduce the time between diagnosis and resection. We propose an algorithm to differentiate between pediatric insulinomas and congenital hyperinsulinism using laboratory data to quicken diagnosis and lessen time to treatment.

  PublisherDOI

• 0966 Youth with Delayed Sleep Phase Have Higher Leptin Levels: The Charisma Study

  SLEEP · 2026-05-01

  article

  Abstract Introduction Adolescents have short and delayed sleep, which may have metabolic consequences. Leptin, an adipocytokine linked with adverse cardiometabolic outcomes when dysregulated, has been associated with shorter sleep in some adolescent studies. We hypothesized that shorter sleep duration and later sleep timing are associated with increased leptin in overweight youth. Methods We enrolled healthy youth 12-21y with BMI>=80%ile (or >=23kg/m2 if >=18y) from three ancestry groups: South Asian (SA), African American (AA), and White (W). Participants wore actigraphy for 14d and underwent a fasting blood draw to measure leptin. We derived average sleep duration, mid-sleep time, and sleep onset. We examined the association between the outcome leptin (log-transformed due to non-normality) and main independent variables of sleep duration and timing using multi-variable linear while adjusting for confounders. Results Participants (n=74, 38F) had median(IQR) age 19.1y(17.5, 20.9), BMIZ 1.1(0.6, 1.6), leptin 24.6ng/mL(12.1, 54.4), sleep duration 7.5h(6.8, 8.0), sleep onset 12:58am(11:56pm, 1:48am) and mid-sleep time 4:34am(3:44am, 5:35am). In univariable models, BMIZ, age, sex, and ancestry were associated with leptin or sleep, and therefore these variables were included in multivariable models. Later mid-sleep time was associated with higher leptin, adjusting for BMIZ, sex, age, and ancestry[p=0.01]. Sleep duration and sleep onset were not associated with leptin. Ancestral groups were similar except for older age [11 SA of median age: 20.7y, 30 AA: 18.4y, 33 W: 19.1y, p=0.02] and later sleep in SA [sleep onset median: SA 1:48am, AA 12:58am, W 12:43am, p=0.02 vs W; mid-sleep time: SA 5:50am, AA 4:29am, W 4:34am, p=0.04 vs W]. We found that (1) in SA, longer sleep durations[p=0.04], later sleep onset[p=0.02], and later mid-sleep time[p=0.02] were associated with higher leptin; (2) in W, later mid-sleep time[p=0.02] was associated with higher leptin. The AA group did not have relationships between sleep and leptin. There was no effect modification by ancestry. Conclusion Later mid-sleep time was associated with higher leptin in overweight youth. These relationships differed across ancestral groups. Further studies are needed to examine if delayed sleep is a modifiable risk factor to help prevent cardiometabolic outcomes, and which factors may heighten ancestry-specific susceptibility. Support (if any) NIH R01DK115648; CTSA: CHOP: UL1TR001878, Hopkins: UL1TR001079

  PublisherDOI

• 0925 Accuracy of Text Message-Based Sleep Diary for Assessment of Sleep Timing and Duration in Youth

  SLEEP · 2026-05-01

  article

  Abstract Introduction Accurate assessment of sleep timing/duration is essential for research and clinical practice. Sleep diaries are an inexpensive and convenient method for assessing sleep, but their accuracy in youth remains unclear. Our research group has used text-messages to administer electronic sleep diaries, which have shown high response rates and rapid response times. We hypothesize that these diaries yield accurate self-reported sleep timing and duration compared to sleep/wake estimation from concomitantly worn wrist actigraphy. Methods Youth 12-21y wore wrist actigraphy (ActiGraph GT3XP-BTLE) and completed twice-daily text-message sleep diaries for 2 weeks. Sleep timing and duration were derived using Cole-Kripke and Tudor-Locke algorithms. Mean sleep onset, offset, duration, and wake after sleep onset (WASO) were compared between actigraphy and sleep diary methods using Wilcoxon rank sum and Bland-Altman analyses. Demographic factors associated with improved diary-actigraphy agreement were assessed using linear regression. Results Participants (n=71,52.1%F) with median (IQR) age 19.1y(17.5,21.0) completed actigraphy and sleep diaries. Average sleep onset, offset, and duration were similar between the two assessment methods by Wilcoxon rank sum (p=0.95 (onset), p=0.15 (offset), p=0.56 (duration)). The absolute magnitude of difference [median(IQR)] was 24.3min (8.4,40.2) for sleep onset, 29.4min (12.5,46.1) for sleep offset, and 36.8min (17.1,68.6) for sleep duration. Per Bland-Altman analysis, the mean differences between diary and actigraphy (positive=diary overestimated) were 1.9min (onset), -5.8min (offset), and -5.3min (duration). 95% limits of agreement were -79.16 to 66.9 minutes (onset), -185.8 to 91.2 minutes (offset), and -94.1 to 58.4 minutes (duration). Proportional bias was 6.6min difference per delayed hour sleep offset, but none was present in onset and duration. There was no heteroscedasticity for any parameter. WASO was significantly different between diary data and actigraphy (p< 0.001). Female sex was associated with improved accuracy of reported sleep duration (p=0.028) but not sleep timing, and age and socioeconomic status were not associated with accuracy of any metric. Conclusion Text-message sleep diaries may provide accurate assessment of sleep onset, offset, and duration in youth when compared to actigraphy, but do not accurately capture WASO. Proportional bias in sleep offset suggests delayed awakening is associated with decreased accuracy in reported offset. Most demographic factors were not associated with reporting accuracy. Support (if any) NIH R01DK115648

  PublisherDOI

• Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study

  Diabetes Care · 2026-04-20

  article

  OBJECTIVE: South Asian individuals are at elevated diabetes risk attributed to insulin resistance, insulin deficiency, and ectopic fat. The CHARISMA study compared metabolic mechanisms in South Asian, White, and African American adolescents and young adults (AYAs) to investigate early diabetes risk in South Asian individuals. RESEARCH DESIGN AND METHODS: AYAs aged 12-21 years with a BMI ≥23 kg/m2 or ≥80 percentile underwent MRI/MRS to quantify fat; OGTT with minimal modeling to calculate insulin sensitivity (Si), AUC insulin secretory rate (ISR), and disposition index (DI); DXA; and glucose-potentiated arginine stimulation test. RESULTS: South Asian AYAs (n = 53, median [interquartile range] age 20.3 [18.9, 21.4] years) compared with White (n = 53, 19.1 [17.6, 20.8] years) and African American (n = 49, 18.8 [17.7, 20.5] years) AYAs (P = 0.02) of similar sex, pubertal stage, and BMI-Z had higher visceral fat on MRI (P < 0.001 vs. White; P = 0.009 vs. African American) and liver fat on MRS (P < 0.001 vs. both). South Asian AYAs had lower Si (P = 0.006) and higher dynamic AUC-ISR (P = 0.003) vs. White AYAs, higher total and static AUC-ISR vs. both White and African American AYAs (P < 0.001), and lower dynamic DI vs. African American AYAs (P = 0.039). South Asian AYAs had lower insulin clearance than White (P = 0.027) and African American (P = 0.007) AYAs. First-pass hepatic insulin extraction was lower in African American than South Asian (P < 0.0001) and White (P = 0.027) AYAs. Group differences in Si, dynamic AUC-ISR, and dynamic DI lost significance when visceral or liver fat was added to models, but higher total and static AUC-ISR in South Asian AYAs persisted. CONCLUSIONS: Compared with White and African American AYAs, South Asian AYAs have higher visceral and liver fat. These findings, along with lower Si and dynamic DI, suggest elevated metabolic risk in South Asian individuals, even at young ages. Higher total and static phase insulin secretion in South Asian AYAs may precede insulin deficiency, reported in adults.

  PublisherDOI

• Geometry of the proximal femur during growth and its contribution to childhood fractures in healthy children

  Journal of Bone and Mineral Research · 2026-05-08

  articleOpen access

  Hip structural analysis (HSA) of proximal femur scans by dual energy X-ray absorptiometry estimates hip geometry and structural strength, but little is known about how these parameters change during peak bone mass development. We describe age-related changes, precision and long-term stability, and sex and race/ethnic identity differences in hip geometry measures by HSA, and test whether HSA measures predict childhood fractures in healthy children. We used data from the Bone Mineral Density in Childhood Study, a multi-center, longitudinal cohort study of 2,014 healthy U.S. children, ages 5-23y, with up to 7 annual visits. HSA measures included cortical thickness, cross-sectional area, cross-sectional moment of inertia, section modulus, buckling ratio, and bone width at the narrow neck and femoral shaft, and hip axis length. Additional measures included self-identified race and ethnicity, Z-scores for height, BMIZ, appendicular lean soft tissue mass index and fat mass index, and self-reported physical activity, calcium intake, Tanner stage and fractures. Results indicated age-related trends and sex differences in hip geometry. Reference ranges were generated and HSA Z-scores were adjusted for height-for-age Z-score. Femoral shaft measures showed better precision (CV: 1.1 to 3.7%) than narrow neck measures (CV: 2.2 to 7.4%); buckling ratio (both sites) was the least precise. HSA Z-scores tracked well over one year (0.77 to 0.94). Narrow neck buckling ratio (HR 1.16 [95% CI: 1.02, 1.31]) and hip axis length Z-scores (HR 1.20 [95% CI: 1.00, 1.44]) associated with fracture risk. When adjusted for covariates (BMD Z-score, BMIZ, Tanner stage, sex), narrow neck cross-sectional area, cross-sectional moment of inertia, section modulus and bone width, and femoral shaft cross-sectional area and section modulus Z-scores positively associated with fractures (e.g., section modulus Z-score associated with 44% increased fracture risk). These findings provide the foundation for evaluating hip geometry as an indicator of bone strength in children.

  PublisherDOI

• 0965 Later Sleep Timing is Related to Worsened Glucose Tolerance in South Asian Youth Likely Secondary to Increased Visceral Fat: The Charisma Study

  SLEEP · 2026-05-01

  article

  Abstract Introduction Adolescents have delayed and shorter sleep, which is associated with adverse metabolic consequences. We hypothesized that later sleep phase is associated with worse glucose tolerance in overweight youth. Methods The Charisma study enrolled youth aged 12-21y with BMI&amp;gt;=80%ile (or&amp;gt;=23kg/m2 if&amp;gt;=18y) from three ancestry groups: South Asian (SA), African American (AA), and White (W). Participants completed actigraphy (14d, ActiGraph GT3XP-BTLE), oral glucose tolerance tests, and Hologic DXA scans to measure visceral fat area (VF). We examined the association between mid-sleep time and 2-hour glucose using linear regression in the combined cohort, then examined whether ancestry and VF affected these associations in stratified analyses and interaction models. Results Participants (n=74, 38F) had median(IQR) age 19.1y(17.5, 20.9) and BMI-Z 1.1(0.64, 1.64). The ancestry groups (11 SA, 30 AA, 33 W) had similar demographics, except the SA group was older [SA: 20.7y(19.2, 21.6), AA: 18.4y(16.8, 20.0), W: 19.1y(17.3, 20.9), p=0.02], had higher VF [SA: 101.9cm2(95.2,121.4), AA: 74.9cm2(53.9,97.7), W: 91.0cm2(66.1,114.3), p=0.03] and later mid-sleep time vs W [SA: 5:50a(3:28a,7:23a), AA: 4:29a(3:34a, 5:45a), W:4:34a(3:53a, 5:10a), p=0.04]. In the full cohort, there was no association between mid-sleep time and 2-hour glucose unadjusted or adjusted for age, sex, BMIZ, ancestry, and sleep duration (p=0.4). In stratified analyses, only the SA group had higher 2-hour glucose with later mid-sleep time unadjusted(β=7.7, p=0.049) and adjusted for the same variables (β=13.1, p=0.04), but lost significance if adjusted for VF in place of BMIZ(β=11.1, p=0.06). In the overall cohort, there was a significant interaction between mid-sleep time and VF in predicting 2-hour glucose unadjusted (p=0.003) and adjusted for age, sex, group, and sleep duration (p=0.011), but no significant interactions by ancestry (p=0.3) or BMI (p=0.7) unadjusted. Conclusion In a combined cohort of overweight youth, glucose tolerance was not related to delayed sleep phase. However, SA youth with later sleep timing had worse glucose tolerance. SA youth exhibited higher VF area, and there was significant effect modification of VF on the relationship between sleep timing and glucose tolerance in the overall cohort. These results suggest that higher VF may influence susceptibility to the glycemic effects of delayed sleep phase. Support (if any) NIH R01DK115648; CTSA: CHOP: UL1TR001878, Hopkins: UL1TR001079

  PublisherDOI

• Assessment of Biochemical Parameters and Other Risk Factors of Diabetes Mellitus Foot Ulcers at a Tertiary Health Center in Southwestern Nigeria

  Bangladesh Journal of Endocrinology and Metabolism · 2025-09-01 · 3 citations

  articleSenior author

  A BSTRACT Background: Patients with diabetes mellitus are prone to many metabolic and biochemical derangements, especially when their blood glucose is not controlled. These metabolic and biochemical derangements can lead to many different complications which could have been prevented if their blood glucose level had been strictly controlled right from the period of diagnosis and strictly adhered to henceforth. Diabetes mellitus foot ulcer is one of the complications found in patients with uncontrolled diabetes mellitus. Diabetes foot ulcers have a complex and multifactorial pathogenesis which includes metabolic and biochemical factors, among other established risk factors. Aim: To determine the common biochemical and metabolic derangements associated with the diabetic foot ulcer. Materials and methods: This was a descriptive, retrospective, single-center study of 100 consecutively recruited adult type 2 diabetes patients managed for diabetes mellitus foot ulcer at the endocrinology unit of a Tertiary Care Hospital in South Western Nigeria (Lagos State University Teaching Hospital Ikeja, Lagos) from February 1, 2022 to February 8, 2023. Demographic and clinical data were obtained from the medical records of each patient using a pretested prestructured questionnaire. The Institutional Ethics Committee approved the study protocol (LREC/October 06, 1986). Data were analyzed using IBM SPSS statistics (Statistical Package for the Social Sciences) software. The power of significance was set at P &lt; 0.05. Results: A total of one hundred clinical case records of subjects with diabetes mellitus foot ulcers were used for this study. The mean age of the subjects was 60.2 ± 10.9 years. The most common comorbidities were hypertension 54 (54.0%) followed by chronic kidney disease 7 (7.0%) and peripheral vascular disease 4 (4.0%). Most of the subjects HbA1c values were deranged. The majority, 36 (80.0%) of those in Wagner’s classification of foot ulcers stage 5, presented with dyslipidemia. More than half 13 (52.0%) of those in stage 4 had proteinuria, whereas 40 (60.0%) of the subjects in stage 2 had deranged creatinine values. There was no significant association between age, dyslipidemia, HbA1c, proteinuria, body mass index, serum creatinine, and DFU. Most of the subjects had stage 5 Wagner’s classification foot ulcers. Conclusion: Our study found some degree of associations between biochemical derangements and diabetic mellitus foot ulcers in patients with type 2 diabetes mellitus. These associations were, however not statistically significant.

  PublisherDOI

• 278-OR: Higher Static Phase Insulin Secretory Rate Compensates for Lower Insulin Sensitivity in South Asian Youth—The Charisma Study

  Diabetes · 2025-06-13

  article

  Introduction and Objective: South Asian (SA) adult studies suggest insulin deficiency contributes to increased T2D risk. Our prior data found higher OGTT insulin in SA vs. White (W) and African American (AA) adolescents and young adults (AYA). Using mathematical modeling, we aim to investigate this finding by characterizing insulin sensitivity (Si), 1st pass hepatic extraction (HE), and the β-cell’s biphasic insulin secretory rates (ISR). Methods: SA, W, and AA AYA with BMI ≥80%ile (≥23kg/m2 if ≥18y) without diabetes underwent 180-min OGTT with derivation of Si by the oral minimal model, HE by the insulin clearance model, and ISR dynamic (1st phase) and static (2nd phase) by the beta-cell function model. ISR AUC for both phases at 180 min were calculated using the trapezoidal method. Disposition index (DI) for both phases: Si x ISR AUC. Ancestry differences were tested with age, sex, and BMIZ-adjusted robust linear regression. Results: AYA [49 SA of mean age: 19.8y, 52 W: 18.9y, 47 AA: 18.8y, p=0.02] did not differ by sex or BMIZ. SA had lower Si [marginal mean (SE): 5.14 (0.77) 104mu/L-1*min-1] vs W [8.25 (0.74); p=0.004] but not vs AA. SA had borderline higher dynamic ISR AUC vs W (p=0.051) but did not differ from AA. Static ISR AUC was 44.7% higher in SA [marginal mean (SE): 27984 (1267) pmol/l] vs W [19334 (1219), p=0.0001] and 66.0% higher in SA vs AA [16858 (1297), p=0.0001]. HE did not differ for SA vs W, but was 13.8% lower in AA vs SA (p=0.0001). DI for both insulin secretory phases did not differ between SA vs W or vs AA. Conclusion: Higher postprandial hyperinsulinemia in SA AYA is due to hypersecretion rather than lower HE. Static phase insulin hypersecretion in SA AYA may precede β-cell failure and T2D in SA adults. Dynamic phase insulin secretion, which typically compensates for lower Si to preserve DI, was unchanged in SA AYA. Future studies can interrogate the roles of alterations in each insulin secretion phase in the progression to β-cell failure and the emergence of T2D in SA. Disclosure T.A. Hitt: None. D. Stefanovski: None. B.S. Zemel: Consultant; Incyte. A. Kelly: None. S.N. Magge: None. Funding NIH NDDK (R01DK115648); CTSA NIH support (UL1TR001878, UL1TR00107)

  PublisherDOI

• 1163-P: Disparities in Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA) Utilization in Pediatric Type 2 Diabetes (T2D)

  Diabetes · 2025-06-13 · 1 citations

  article

  Introduction and Objective: Disparities in GLP-1 RA use by race/ethnicity and socioeconomic status are documented in adult T2D. To assess if similar disparities occur in pediatric T2D, the association between GLP-1 RA prescriptions and race/ethnicity amongst Medicaid-insured youths with T2D was examined. Methods: A cross-sectional study of youths aged 10-17 years (y) with T2D (2021-2022) was conducted using the Merative MarketScan Medicaid Database. Multivariable logistic regression was used to assess associations of GLP-1 RA prescription ever prescribed (yes/no) with race/ethnicity and potential confounders (age, sex, obesity, co-morbidities, and use of metformin or insulin). Results: Among 4000 youths (57.7 % female, 33.1% NH White, 47.2% NH Black, 13.0% Hispanic, 6.7% Other, mean age: 14.9 y [SD 1.9]), GLP-1 RAs were prescribed in 23.3% (liraglutide 17.5%, dulaglutide 4.4%, exenatide 2.3%, semaglutide 2.2%) and less frequently than metformin (73.8%) and insulin (64.0%). After covariate adjustment, Hispanic ethnicity, but not Black race, was associated with lower odds of GLP-1 RA prescription compared to NH White (OR 0.57 [95% CI 0.43, 0.76], p &amp;lt; 0.001) (Figure 1). Conclusion: Among Medicaid-insured youths with T2D, Hispanic youths were less likely to be prescribed GLP-1 RAs. Developing strategies to ensure equitable access to novel treatments in pediatric T2D are needed. Disclosure P.Y. Chu: None. A. Kelly: None. M. Vajravelu: None. S. Hennessy: Consultant; Novo Nordisk, AstraZeneca, Urovant Sciences, i2o Therapeutics, Basilea, Eli Lilly and Company, Balance Opthalmics, Inc, Applied Therapeutics, GlaxoSmithKline plc, Lycos Therapeutics. S. Amaral: Consultant; Bristol-Myers Squibb Company. Funding National Institute of Diabetes and Digestive and Kidney Diseases (F32DK138739); National Institute of General Medical Sciences (T32GM075766)

  PublisherDOI

• Arterial Stiffness and Central Hemodynamics in South Asian, African American, and White Adolescents and Young Adults—The Charisma Study

  American Journal of Hypertension · 2025-07-18 · 1 citations

  articleOpen access1st authorCorresponding

  BACKGROUND: Compared to individuals of European or African ancestry, individuals of South Asian (SA) ancestry have greater cardiovascular disease (CVD) risk. We aimed to compare arterial stiffness and central hemodynamics, surrogates of CVD, in adolescents and young adults (AYA) of SA, White, and African American (AA) ancestry with overweight or obesity. METHODS: Pulse wave velocity (PWV) and pulse wave analysis (PWA metrics: Pulse Pressure Amplification [PPA]; Augmentation Index adjusted to heart rate of 75 [Aix75]) were performed in a cross-sectional study of 40 (18M/22F) SA, 45 (16M/29F) AA, and 44 (21M/24F) White AYA (age 12-21 years) of comparable age, sex, and BMI. Between-group comparisons of PWV, PPA, and AIx-75 were tested using linear regression models adjusted for covariates (BMI, mean arterial pressure, sex, age), as appropriate. RESULTS: As expected, BMI (kg/m2) did not differ (SA: 27.1, AA: 28.4, White: 27.4). Mean PWV (m/s) did not differ in SA (5.5), AA (5.1), and White (5.5). The typical relationship of BMI with PWV was absent in SA. PPA was lower in SA (1.45, P = 0.001) and AA (1.48, P = 0.014) vs. White (1.56). Aix75 was higher in SA (108, P = 0.004) but not in AA (105, P = 0.12) vs. White (101). CONCLUSIONS: Although their PWV did not differ, SA AYA had lower PPA and higher Aix75 compared to White counterparts. As lower PPA associates with higher likelihood of future CV events, these findings could reflect an early CVD predisposition in SA and underscore the potential value of pulse waveform analysis in studies of emerging adults, a life stage in which interventions may mitigate CVD risk.

  PublisherOA PDFDOI

Recent grants

• NIH Grant M01RR000240

  NIH · $6.4M · 2006

• Evaluation of the entero-insular (incretin) axis in cystic fibrosis-competitive renewal.

  NIH · $147k · 2012–2020

• Evaluation of the entero-insular (incretin) axis in cystic fibrosis-competitive renewal.

  NIH · $5.7M · 2012–2026

• Cardiometabolic Risk Factors and Obesity in Adolescents with Down Syndrome

  NIH · $2.8M · 2012–2019

• Translational Research Training in Pediatric Diabetes & Endocrinology

  NIH · $5.2M · 2002–2029

Frequent coauthors

• O Gressner

  Laboratory Dr. Wisplinghoff

  543 shared

• Cheryl R. Greenberg

  376 shared

• William Lane M. Robson

  360 shared

• Maria Rita Passos‐Bueno

  Universidade de São Paulo

  360 shared

• Cord Sunderkötter

  University Hospital in Halle

  358 shared

• Tracey Weiler

  Florida International University

  358 shared

• Patrick Frosk

  University of Manitoba

  356 shared

• Wolfgang Dietmaier

  University of Regensburg

  356 shared

Labs

• Kelly LabPI