
Dennis B Liu
· Associate Professor, Urology (Pediatric Urology)VerifiedNorthwestern University · Urology
Active 2002–2026
About
Dennis B Liu is an Associate Professor in the Department of Urology at Northwestern University Feinberg School of Medicine, specializing in Pediatric Urology. He is affiliated with the Center for Reproductive Science and the Northwestern University Clinical and Translational Sciences Institute (NUCATS). His professional focus includes pediatric urological conditions, reproductive health, and related research areas. Further details about his specific research contributions or background are not provided on the page.
Research topics
- Andrology
- Internal medicine
- Medicine
- Endocrinology
- Gynecology
- Obstetrics
- Computer Science
- Genetics
- Biology
- Physiology
- Pathology
- Chemistry
- Database
- Oncology
Selected publications
The Journal of Urology · 2026-04-27
articleThe Journal of Urology · 2025-04-08
articleUrology · 2025-11-21
article2023
- Endocrinology
- Internal medicine
- Andrology
<div>Abstract<p>Sex steroid hormones contribute to breast cancer development, but data on concentrations of these within breast tissue are limited. We performed simultaneous multiparameter measurement of breast sex steroids, breast epithelial cytology, and DNA methylation in 119 healthy women (54 pre- and 65 postmenopausal) without a history of breast cancer. Random fine-needle aspiration (rFNA) of the breast was performed simultaneously with blood collection. Breast samples were analyzed by LC/MS-MS for estrone, estradiol, progesterone, androstenedione, and testosterone. Blood samples were assayed for estradiol and progesterone by immunoassay. Cytomorphology was classified using the Masood Score, and DNA methylation of eight genes was analyzed using quantitative multiplexed methylation-specific PCR, and expressed as the cumulative methylation index (CMI). Serum and breast concentrations of estradiol and progesterone showed significant correlation (Spearman <i>r</i> = 0.34, <i>P</i><sub>adj</sub> = 0.001 and <i>r</i> = 0.69, <i>P</i><sub>adj</sub> < 0.0006, respectively). Progesterone concentration was significantly higher in the premenopausal breast (<i>P</i><sub>adj</sub> < 0.0008), and showed a luteal surge. Breast estrone and estradiol concentrations did not differ significantly by menopause, but androstenedione concentration was higher in the breasts of postmenopausal women (<i>P</i> = 0.026 and <i>P</i><sub>adj</sub> = 0.208). Breast androgens were significantly correlated with breast density (Spearman <i>r</i> = 0.27, <i>P</i><sub>adj</sub> = 0.02 for testosterone) and CMI (Spearman <i>r</i> = 0.3, <i>P</i><sub>adj</sub> = 0.038 for androstenedione). Our data indicate that future larger studies of breast steroid hormones along with other parameters are feasible. Significant associations of breast androgen concentrations with breast density and gene methylation warrant future study. <i>Cancer Prev Res; 11(9); 557–68. ©2018 AACR</i>.</p></div>
Journal of Pediatric Urology · 2023-06-24 · 1 citations
letter2023
- Andrology
- Gynecology
- Physiology
<p>Table S1. Correlations between parameters that influence the quality of the rFNA sample (119 women) Table S2. Correlation between Breast and serum hormone concentrations. Table S3. Cytology according to menopausal status and menstrual cycle.</p>
2023
- Computer Science
- Gynecology
- Andrology
<p>Table S1. Correlations between parameters that influence the quality of the rFNA sample (119 women) Table S2. Correlation between Breast and serum hormone concentrations. Table S3. Cytology according to menopausal status and menstrual cycle.</p>
Urology · 2023-11-17 · 5 citations
articleJournal of Pediatric Urology · 2022 · 10 citations
Corresponding- Medicine
- Surgery
- Medical physics
Journal of Pediatric Urology · 2022-10-10 · 2 citations
articleCorresponding
Frequent coauthors
- 119 shared
Alfred Rademaker
University of Chicago
- 54 shared
Charles L. Bennett
- 52 shared
Terry C. Davis
- 45 shared
Michael S. Wolf
Northwestern University
- 40 shared
Paul R. Haut
Indianapolis Zoo
- 40 shared
Susan L. Cohn
- 40 shared
Howard M. Katzenstein
Ono Pharmaceutical (United States)
- 40 shared
Jennifer Schmoldt
Northwestern University
Education
M.D.
Northwestern University Feinberg School of Medicine
B.S.
University of California, San Diego
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