Alice Frigerio
· Assistant Professor (Clinical)VerifiedUniversity of Utah · Dermatology
Active 1977–2026
About
Alice Frigerio, MD, PhD, completed residency training in both Maxillofacial Surgery and Dermatology. In 2021, after her fellowship training in Micrographic Surgery and Cutaneous Oncology, she joined the Mohs team to focus on management of high-risk skin cancer patients, vascular anomalies, laser treatment of skin disease, and cosmetic surgery. With nearly two decades of experience in the field of vascular anomalies, she is an advocate for patients with cutaneous birthmarks. She is a member of the University of Utah interdisciplinary Vascular Anomalies Team and HHT Center. Dr. Frigerio enjoys the diagnostic workup that enables tailoring the care for each case and delivers safe, straightforward laser treatments that do not require general anesthesia. Her specialties include Dermatology, Mohs Surgery, Laser and Cosmetic Dermatology, Melanoma Surgery, High-Risk Skin Cancer, Melanoma and Cutaneous Oncology, Hyperhidrosis, and Vascular Anomalies. She is board-certified by the American Board of Dermatology in Dermatology and Micrographic Dermatologic Surgery.
Research signals
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Research topics
- Medicine
- Pathology
- Biology
- Artificial Intelligence
- Dermatology
- Anatomy
- Genetics
Selected publications
JAAD International · 2026-05-01
articleOpen accessSenior authorMendeley Data · 2026-04-28
datasetOpen accessSenior authorSupplemental data for Melanoma Disparities in Utah: Disproportionate Rates Among Hispanic and Non-White Populations sin a Population-Based Analysis
Chronic Recalcitrant Auricular Chondritis and Cauliflower Ear After Mohs Micrographic Surgery
Dermatologic Surgery · 2026-01-15
articleSenior authorMolecular Characterization of Vascular Anomalies Tissues Guides Clinical Diagnosis
Lymphatic Research and Biology · 2026-01-23
articleBackground: Vascular anomalies are a group of common endothelial disorders that manifest a wide range of overlapping phenotypes, which complicate diagnosis. Next-generation sequencing (NGS) has led to the ability to detect low-frequency somatic variants, which may aid in the correct diagnosis and treatment of patients. Our goal was to identify the pathogenic variants in affected tissue taken from a cohort of 58 unrelated patients with various clinically diagnosed vascular anomalies. Methods: DNA was extracted from fresh/frozen affected tissue samples and evaluated using a custom 735 vascular anomaly/cancer gene NGS panel down to 1% somatic mosaicism. Results: Pathogenic or likely pathogenic variants were identified in 47% (27/58) of vascular anomaly tissue biopsies, including 61.5% (16/26) of lymphatic malformation (LM), 15% (3/20) of hemangioma (congenital and infantile), and 67% (8/12) of other various vascular anomalies. Two novel variants, PIK3CA c.3205_3206insTTTT (p.*1069Pheext*4) and PIK3R1 c.1384_1395del (p.Glu462_Arg465del), were identified in LM tissue. In addition, we report a likely pathogenic variant GNA14 c.512C>T (p.Thr171Ile) identified in a GLUT-1 positive infantile hemangioma lesion. The majority (52%) of the negative results were in infantile hemangioma tissue, for which a genetic cause has not yet been established. Conclusions: The 735 gene vascular anomaly/cancer NGS panel is an effective way to detect low levels of somatic mosaicism in these lesions. Given the challenge that many vascular anomalies present to diagnose, genetic testing is an invaluable tool for clinicians to utilize in the process of diagnosis and determining treatment.
Mendeley Data · 2026-04-28
datasetOpen accessSenior authorSupplemental data for Melanoma Disparities in Utah: Disproportionate Rates Among Hispanic and Non-White Populations sin a Population-Based Analysis
2025-07-28
preprintOpen access<p>Key demographic characteristics of patients with LM/LMM in the study (<i>n</i> = 175)</p>
2025-07-28
preprintOpen access<div>Abstract<p>Lentigo maligna (LM) and lentigo maligna melanoma (LMM) arise from chronically sun-damaged skin. LM/LMM incidence continues to increase, particularly in Utah, where melanoma rates are twice the national average. The melanocortin-1 receptor (<i>MC1R</i>) has been studied in melanocyte pigmentation and DNA repair but has yet to be thoroughly investigated in LM/LMM. We investigated allele and genotype frequencies of germline <i>MC1R</i> variants among 175 Utah patients diagnosed with LM/LMM and 402 Utah reference individuals. The comparative analysis demonstrated an increased frequency of the D294H allele (0.046; <i>P</i> = 0.0042) and a decreased frequency of the V60L allele (0.074; <i>P</i> = 0.034) in patients with LM/LMM. The LM/LMM group demonstrated a higher OR compared with the Utah reference group associated with R151C homozygosity compared with heterozygous R151C [OR = 5.6; 95% confidence interval (CI), 0.98–32; <i>P</i> = 0.052] and R151C homozygosity compared with wild type (OR = 5.7; 95% CI, 1.1–30; <i>P</i> = 0.042). D294H heterozygosity was strongly associated with LM/LMM (OR = 3.8; 95% CI, 1.3–11; <i>P</i> = 0.014). Conversely, V60L heterozygosity was less strongly associated with LM/LMM (OR = 0.52; 95% CI, 0.26–1.1; <i>P</i> = 0.072). Stratified analyses showed no significant differences in age or gender across the key <i>MC1R</i> variants studied. These data highlight significant differences in <i>MC1R</i> allele frequencies in patients with LM/LMM, demonstrating that D294H is associated with increased LM/LMM risk, whereas the V60L variant is inversely associated with risk. This study provides the first comprehensive analysis of specific high-risk <i>MC1R</i> variants in patients with LM/LMM in Utah.</p>Significance:<p>Our study is the first comprehensive analysis of <i>MC1R</i> germline variants in patients with LM/LMM in Utah, a region with an exceptionally high melanoma incidence. We draw new risk associations in LM/LMM, identifying an increased risk with the D294H and R151C variants. We also describe a novel inverse association for V60L, warranting further investigation. This study contributes to improved targeted risk stratification and an increased understanding of an understudied melanoma subtype.</p></div>
2025-07-28
supplementary-materialsOpen access<p>Table of the Utah reference group data</p>
Dermatologic Surgery · 2025-04-23
articleSenior authorAssessing <i>MC1R</i> Variants in Lentigo Maligna Melanoma within the Utah Population
Cancer Research Communications · 2025-07-01
articleOpen accessLentigo maligna (LM) and lentigo maligna melanoma (LMM) arise from chronically sun-damaged skin. LM/LMM incidence continues to increase, particularly in Utah, where melanoma rates are twice the national average. The melanocortin-1 receptor (MC1R) has been studied in melanocyte pigmentation and DNA repair but has yet to be thoroughly investigated in LM/LMM. We investigated allele and genotype frequencies of germline MC1R variants among 175 Utah patients diagnosed with LM/LMM and 402 Utah reference individuals. The comparative analysis demonstrated an increased frequency of the D294H allele (0.046; P = 0.0042) and a decreased frequency of the V60L allele (0.074; P = 0.034) in patients with LM/LMM. The LM/LMM group demonstrated a higher OR compared with the Utah reference group associated with R151C homozygosity compared with heterozygous R151C [OR = 5.6; 95% confidence interval (CI), 0.98-32; P = 0.052] and R151C homozygosity compared with wild type (OR = 5.7; 95% CI, 1.1-30; P = 0.042). D294H heterozygosity was strongly associated with LM/LMM (OR = 3.8; 95% CI, 1.3-11; P = 0.014). Conversely, V60L heterozygosity was less strongly associated with LM/LMM (OR = 0.52; 95% CI, 0.26-1.1; P = 0.072). Stratified analyses showed no significant differences in age or gender across the key MC1R variants studied. These data highlight significant differences in MC1R allele frequencies in patients with LM/LMM, demonstrating that D294H is associated with increased LM/LMM risk, whereas the V60L variant is inversely associated with risk. This study provides the first comprehensive analysis of specific high-risk MC1R variants in patients with LM/LMM in Utah. SIGNIFICANCE: Our study is the first comprehensive analysis of MC1R germline variants in patients with LM/LMM in Utah, a region with an exceptionally high melanoma incidence. We draw new risk associations in LM/LMM, identifying an increased risk with the D294H and R151C variants. We also describe a novel inverse association for V60L, warranting further investigation. This study contributes to improved targeted risk stratification and an increased understanding of an understudied melanoma subtype.
Frequent coauthors
- 53 shared
Paolo Severgnini
University of Insubria
- 52 shared
Paolo Pelosi
- 52 shared
Maurizio Chiaranda
Ospedale Garibaldi
- 50 shared
Marcus J. Schultz
Amsterdam University Medical Centers
- 50 shared
Gianlorenzo Dionigi
IRCCS Istituto Auxologico Italiano
- 50 shared
Gabriele Selmo
- 50 shared
Emmanuel Futier
Centre Hospitalier Universitaire de Clermont-Ferrand
- 50 shared
Alessandro Chiesa
Ospedale Regionale di Bellinzona e Valli
Education
M.D.
University of Utah
Ph.D.
University of Utah
- 2021
Other, Micrographic Surgery and Cutaneous Oncology
University of Utah
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