1552 Clinicopathologic and Molecular Spectrum of Hepatic Lesions enriched in CTNNB1 mutations in Pediatric Patients and Young Adults with Congenital Portosystemic Shunt

Laboratory Investigation · 2026-03-01

Characterization and Management of a Rare Recurrent Pediatric Papillary Hemangioma

Plastic & Reconstructive Surgery Global Open · 2026-02-01

Papillary hemangiomas (PHs) are rare, benign vascular tumors, typically described in adults. Few pediatric cases have been reported, and recurrence is uncommon. We presented a unique case of PH in a 15-month-old male patient with recurrence after surgical excision. The patient presented with a left cheek lesion present since birth, which had grown proportionally with his development. Initial ultrasound demonstrated a superficial, hypoechoic, heterogeneous lesion with increased vascularity. Surgical excision was performed, and pathology demonstrated large, thin-walled, irregular vascular channels with arborizing fronds, eosinophilic hyaline globules, and CD31+ endothelial cells, findings consistent with PH. Four months postoperatively, imaging revealed recurrence. Re-excision was performed, including branching structures initially thought to be nutrient vessels. Nitro paste was applied postoperatively due to concern for the thin overlying skin. PH is rarely congenital and can be misdiagnosed as other vascular anomalies. This case emphasized the importance of recognizing branching structures that may represent lesion extensions to optimize complete excision. Multidisciplinary management is recommended for diagnosis, treatment planning, and follow-up.

Voluntary Euthanasia and Moral Philosophy: An Ethical Perspective

Zenodo (CERN European Organization for Nuclear Research) · 2026-01-12

Voluntary euthanasia remains a highly contested ethical issue, balancing individual autonomy against societal responsibilities. This study explores the philosophical foundations of voluntary euthanasia by analyzing ethical theories such as utilitarianism, deontology, virtue ethics, and rights-based perspectives. It examines the moral justifications from diverse philosophical standpoints while addressing the legal and ethical tensions between personal choice and collective moral obligations. A qualitative research approach is employed to investigate how different frameworks shape contemporary debates on euthanasia. Findings highlight the complex interplay between individual rights, medical ethics, and legal safeguards, underscoring the need for a balanced approach that respects personal dignity while ensuring ethical integrity. The study contributes to academic discourse by offering a nuanced understanding of euthanasia's moral and legal implications.

1550 Revisiting Comparative Adequacy of Liver Biopsy Specimen for Histopathologic Evaluation in the Pediatric Population: A One Year Institutional Review

Laboratory Investigation · 2026-03-01

Voluntary Euthanasia and Moral Philosophy: An Ethical Perspective

Zenodo (CERN European Organization for Nuclear Research) · 2026-01-12

Voluntary euthanasia remains a highly contested ethical issue, balancing individual autonomy against societal responsibilities. This study explores the philosophical foundations of voluntary euthanasia by analyzing ethical theories such as utilitarianism, deontology, virtue ethics, and rights-based perspectives. It examines the moral justifications from diverse philosophical standpoints while addressing the legal and ethical tensions between personal choice and collective moral obligations. A qualitative research approach is employed to investigate how different frameworks shape contemporary debates on euthanasia. Findings highlight the complex interplay between individual rights, medical ethics, and legal safeguards, underscoring the need for a balanced approach that respects personal dignity while ensuring ethical integrity. The study contributes to academic discourse by offering a nuanced understanding of euthanasia's moral and legal implications.

A Qualitative Analysis of Clinicians’ Approaches to Pulmonary Nodule Evaluation and Management

American Journal of Respiratory and Critical Care Medicine · 2025-05-01

Abstract RATIONALE: Pulmonary nodule (PN) evaluation and management requires complex medical decision-making and poses a diagnostic challenge for clinicians, who must estimate PN malignancy risk to determine whether the benefits and risks of lung biopsy or empiric treatment are worthwhile for patients. In the setting of paradigm-shifting advances in lung cancer diagnostic techniques and treatment over the past decade, we sought to characterize clinicians’ current PN evaluation and management practices and perspectives. METHODS: We performed semi-structured qualitative interviews with 25 clinicians with PN expertise across 16 U.S. healthcare systems. Interviews probed clinicians’ approaches to PN malignancy risk assessment and management decision-making and their perspectives on PN clinical care challenges, barriers to optimal care, and current PN clinical guidelines. Interviews were performed either in-person or via telephone by either R.Y.K. or A.G. Transcripts of audio-recorded interviews were analyzed using principles of grounded theory. RESULTS: Among the 25 participants (20 [80%] attendings, 2 [8%] fellows, 3 [12%] advanced practice providers; 9 [36%] women; 15 [60%] non-Hispanic White), years of experience ranged from 0 to 30 years (mean: 8 years), 20 (80%) practiced in an academic setting, 13 (52%) practiced within a dedicated PN clinic, 12 (48%) specialized in general pulmonology, 10 (40%) interventional pulmonology, and 3 (12%) thoracic surgery. Key themes (Table) included personal review of PN imaging characteristics as the major driver of malignancy risk assessment; variable use and perceptions of risk assessment tools to quantify PN malignancy risk; conflicting opinions on prioritization of unnecessary invasive diagnostic procedure reduction vs. sensitivity for lung cancer detection; heterogeneous approaches to diagnostic evaluation of intermediate- and high-risk PNs; universal belief in patient preference and overall health strongly impacting PN management decisions; a belief that a multidisciplinary approach to PN evaluation and management is critical; a desire to overcome barriers to timely access to PN care and standardized follow-up; and widely divergent views on the usefulness and relevance of current PN clinical guidelines. CONCLUSIONS: Current PN evaluation and management practices in the U.S. are highly heterogeneous, reflecting a lack of consensus among clinicians with PN expertise. Despite this, clinicians agree that personal PN imaging review, shared decision-making with patients, a multidisciplinary approach, and a need for improved patient access and follow-up care are important aspects of modern-day PN clinical care. As there is no clearly defined standard of care, future prospective, randomized controlled trials are necessary to determine the optimal approach to PN evaluation and management.

The Application of Ethical Theories to Voluntary Euthanasia: A Pragmatic Approach in Philosophy

Zenodo (CERN European Organization for Nuclear Research) · 2025-12-08

The ethical and legal dimensions of voluntary euthanasia continue to be a subject of intense debate, with perspectives shaped by various philosophical theories. This study applies a pragmatic approach to analyze how ethical theories, including deontology, utilitarianism, virtue ethics, and ethical pluralism, influence decision-making in voluntary euthanasia. The research explores the balance between individual autonomy and societal responsibilities, addressing the tensions arising from moral and legal frameworks. By employing an explorative qualitative methodology, the study critically evaluates the practical implications of these ethical theories in real-world scenarios. Pragmatic ethics emerges as a reconciliatory framework, enabling a context-driven, flexible approach to voluntary euthanasia while ensuring ethical accountability. The findings suggest that ethical pluralism offers a comprehensive solution to the diverse perspectives on voluntary euthanasia, advocating for a policy framework that respects both personal dignity and collective moral values.

The Application of Ethical Theories to Voluntary Euthanasia: A Pragmatic Approach in Philosophy

Zenodo (CERN European Organization for Nuclear Research) · 2025-12-08

The ethical and legal dimensions of voluntary euthanasia continue to be a subject of intense debate, with perspectives shaped by various philosophical theories. This study applies a pragmatic approach to analyze how ethical theories, including deontology, utilitarianism, virtue ethics, and ethical pluralism, influence decision-making in voluntary euthanasia. The research explores the balance between individual autonomy and societal responsibilities, addressing the tensions arising from moral and legal frameworks. By employing an explorative qualitative methodology, the study critically evaluates the practical implications of these ethical theories in real-world scenarios. Pragmatic ethics emerges as a reconciliatory framework, enabling a context-driven, flexible approach to voluntary euthanasia while ensuring ethical accountability. The findings suggest that ethical pluralism offers a comprehensive solution to the diverse perspectives on voluntary euthanasia, advocating for a policy framework that respects both personal dignity and collective moral values.

Applying Generative AI in a Global Language School to Improve Curriculum Planning

Advances in computational intelligence and robotics book series · 2025-04-24 · 2 citations

Teaching and learning methodologies are being completely transformed by new developments in educational technology. The way that individual courses and instructional units are designed in the classroom will be significantly impacted by these technological tools. This chapter will look at how to design a competency-based unit of instruction that complies with ACTFL (2024) proficiency requirements using generative artificial intelligence. The summative assessment is structured as an integrated performance assessment, and the chapter is arranged using a backwards-design approach. This chapter will teach teachers how to use AI technologies to generate the IPA first, and then it will teach them how to design real-world classroom activities that will provide students experience in the three communication modes—interpersonal, presentational, and interpretative. The chapter will also cover how to employ generative AI to enhance target language learning, given that feedback is a crucial component of the recursiveness of instructional design in a global language classroom.

1643 A Multi-Institutional Case Series of Eccrine Angiomatous Hamartoma

Laboratory Investigation · 2025-03-01