About

Chase Linsley is an Associate Adjunct Professor in the Bioengineering department at UCLA Samueli School of Engineering. His research interests include biomaterials, degradable implants, smart drug delivery systems, tissue engineering, and translational research. He holds a B.S. in Bioengineering from California Lutheran University, obtained in 2008, and an M.S. and Ph.D. in Biomedical Engineering from UCLA, earned in 2009 and 2015 respectively. His doctoral mentor was Benjamin Wu, D.D.S., Ph.D. Linsley's notable awards include the Extramural Loan Repayment Award from NIH/NHLBI from 2020 to 2022 and a Dissertation Year Fellowship at UCLA in 2014.

Research topics

• Composite material
• Materials science
• Metallurgy
• Chemical engineering
• Nanotechnology

Selected publications

• Immune-instructive biomaterials in oral tissue regeneration and therapy

  Biomaterials · 2026-04-24 · 1 citations

  article
  PublisherDOI

• Systematic Study of Tic Nanoparticle Effects on the Fatigue Behavior of Zn and Zn Alloys

  SSRN Electronic Journal · 2025-01-01

  preprintOpen access
  PublisherDOI

• Systematic study of TiC nanoparticle effects on the fatigue behavior of Zn and Zn alloys

  Journal of Alloys and Compounds · 2025-08-21 · 1 citations

  article
  PublisherDOI

• Nanoparticle-Enabled Zn-0.1Mg Alloy with Long-Term Stability, Refined Degradation, and Favorable Biocompatibility for Biodegradable Implant Devices

  ACS Applied Materials & Interfaces · 2024-09-16 · 25 citations

  article

  Zinc-based alloys, specifically Zn–Mg, have garnered considerable attention as promising materials for biodegradable implants due to their favorable mechanical strength, appropriate corrosion rate, and biocompatibility. Nevertheless, the alloy’s lack of mechanical stability and integrity, resulting from ductility loss induced by age hardening at room temperature, hampers its practical bioapplication. In this study, ceramic nanoparticles have been successfully incorporated into the Zn–Mg alloy system, leading to a significant improvement in long-term stability as well as mechanical strength and ductility. In addition, this study represents the first investigation of Zn-based nanocomposites both in vitro and in vivo to comprehend the influence of nanoparticles on the degradation behavior and biocompatibility of the Zn system. The findings indicate that the incorporation of WC nanoparticles effectively refines and stabilizes the degradation behavior of Zn–Mg without negatively impacting the cytocompatibility of the alloy. The subcutaneous implantation and femoral implantation further prove the benefits of nanoparticle incorporation and found no negative effects. Collectively, Zn–Mg–WC nanocomposites yield great potential for implant usage.

  PublisherDOI

• Effect of TiC Nanoparticles on a Zn-Al-Cu System for Biodegradable Cardiovascular Stent Applications

  ACS Biomaterials Science & Engineering · 2024-04-02 · 12 citations

  article

  Despite being a weaker metal, zinc has become an increasingly popular candidate for biodegradable implant applications due to its suitable corrosion rate and biocompatibility. Previous studies have experimented with various alloy elements to improve the overall mechanical performance of pure Zn without compromising the corrosion performance and biocompatibility; however, the thermal stability of biodegradable Zn alloys has not been widely studied. In this study, TiC nanoparticles were introduced for the first time to a Zn-Al-Cu system. After hot rolling, TiC nanoparticles were uniformly distributed in the Zn matrix and effectively enabled phase control during solidification. The Zn-Cu phase, which was elongated and sharp in the reference alloy, became globular in the nanocomposite. The strength of the alloy, after introducing TiC nanoparticles, increased by 31% from 259.7 to 340.3 MPa, while its ductility remained high at 49.2% elongation to failure. Fatigue performance also improved greatly by adding TiC nanoparticles, increasing the fatigue limit by 47.6% from 44.7 to 66 MPa. Furthermore, TiC nanoparticles displayed excellent phase control capability during body-temperature aging. Without TiC restriction, Zn-Cu phases evolved into dendritic morphologies, and the Al-rich eutectic grew thicker at grain boundaries. However, both Zn-Cu and Al-rich eutectic phases remained relatively unchanged in shape and size in the nanocomposite. A combination of exceptional tensile properties, improved fatigue performance, better long-term stability with a suitable corrosion rate, and excellent biocompatibility makes this new Zn-Al-Cu-TiC material a promising candidate for biodegradable stents and other biodegradable applications.

  PublisherDOI

• Engineering Materials and Devices for the Prevention, Diagnosis, and Treatment of COVID-19 and Infectious Diseases

  Nanomaterials · 2023-08-30 · 8 citations

  reviewOpen access

  Following the global spread of COVID-19, scientists and engineers have adapted technologies and developed new tools to aid in the fight against COVID-19. This review discusses various approaches to engineering biomaterials, devices, and therapeutics, especially at micro and nano levels, for the prevention, diagnosis, and treatment of infectious diseases, such as COVID-19, serving as a resource for scientists to identify specific tools that can be applicable for infectious-disease-related research, technology development, and treatment. From the design and production of equipment critical to first responders and patients using three-dimensional (3D) printing technology to point-of-care devices for rapid diagnosis, these technologies and tools have been essential to address current global needs for the prevention and detection of diseases. Moreover, advancements in organ-on-a-chip platforms provide a valuable platform to not only study infections and disease development in humans but also allow for the screening of more effective therapeutics. In addition, vaccines, the repurposing of approved drugs, biomaterials, drug delivery, and cell therapy are promising approaches for the prevention and treatment of infectious diseases. Following a comprehensive review of all these topics, we discuss unsolved problems and future directions.

  PublisherOA PDFDOI

• Corrosion behavior of nano-treated AA7075 alloy with TiC and TiB2 nanoparticles

  Corrosion Science · 2022 · 94 citations

  • Materials science
  • Metallurgy
  • Composite material
  PublisherDOI

• Experimental study on novel biodegradable <scp>Zn</scp>–<scp>Fe</scp>–<scp>Si</scp> alloys

  Journal of Biomedical Materials Research Part B Applied Biomaterials · 2022-05-06 · 10 citations

  articleOpen access

  Bioabsorbable metals are increasingly attracting attention for their potential use as materials for degradable implant devices. Zinc (Zn) alloys have shown great promises due to their good biocompatibility and favorable degradation rate. However, it has been difficult to maintain an appropriate balance among strength, ductility, biocompatibility, and corrosion rate for Zn alloys historically. In this study, the microstructure, chemical composition, mechanical properties, biocompatibility, and corrosion rate of a new ternary zinc-iron-silicon (Zn-Fe-Si) alloy system was studied as a novel material for potential biodegradable implant applications. The results demonstrated that the in situ formed Fe-Si intermetallic phases enhanced the mechanical strength of the material while maintaining a favorable ductility. With Fe-Si reinforcements, the microhardness of the Zn alloys was enhanced by up to 43%. The tensile strength was increased by up to 76% while elongation to failure remained above 30%. Indirect cytotoxicity testing showed the Zn-Fe-Si system had good biocompatibility. Immersion testing revealed the corrosion rate of Zn-Fe-Si system was not statistically different from pure Zn. To understand the underlying phase formation mechanism, the reaction process in this ternary system during the processing was also studied via phase evolution and Gibbs free energy analysis. The results suggest the Zn-Fe-Si ternary system is a promising new material for bioabsorbable metallic medical devices.

  PublisherOA PDFDOI

• Corrosion performance of nano‐treated aluminum alloy A206 with TiC nanoparticles

  Materials and Corrosion · 2022-10-21 · 10 citations

  article

  Abstract A206 aluminum alloy is an important Al‐cast alloy with high mechanical strength. However, its dependence on θ′‐phase for effective strengthening raises concern for its anti‐corrosion performance in service. This paper systematically studies nano‐treating A206 with TiC nanoparticles to investigate its effects on overall corrosion behavior. Immersion tests and electrochemical measurements have been used to understand the nano‐treating contributions to the improved corrosion resistance of A206 under T4 and T6 heat treatment. The results indicate that the pseudo‐dispersion of TiC at or near the grain boundary (GB) and precipitates strengthens the GBs, and more rapid passivation near the TiC‐dense zone introduces a more uniform corrosion feature. The uniform corrosion with rapid passivation greatly facilitates the corrosion control of nano‐treated A206 under T4 and T6 heat treatment, allowing supreme anti‐corrosion stability for high‐strength A206 alloy.

  PublisherDOI

• Functionalizing Fibrin Hydrogels with Thermally Responsive Oligonucleotide Tethers for On-Demand Delivery

  Bioengineering · 2022-01-10 · 8 citations

  articleOpen access1st authorCorresponding

  There are a limited number of stimuli-responsive biomaterials that are capable of delivering customizable dosages of a therapeutic at a specific location and time. This is especially true in tissue engineering and regenerative medicine applications, where it may be desirable for the stimuli-responsive biomaterial to also serve as a scaffolding material. Therefore, the purpose of this study was to engineer a traditionally non-stimuli responsive scaffold biomaterial to be thermally responsive so it could be used for on-demand drug delivery applications. Fibrin hydrogels are frequently used for tissue engineering and regenerative medicine applications, and they were functionalized with thermally labile oligonucleotide tethers using peptides from substrates for factor XIII (FXIII). The alpha 2-plasmin inhibitor peptide had the greatest incorporation efficiency out of the FXIII substrate peptides studied, and conjugates of the peptide and oligonucleotide tethers were successfully incorporated into fibrin hydrogels via enzymatic activity. Single-strand complement oligo with either a fluorophore model drug or platelet-derived growth factor-BB (PDGF-BB) could be released on demand via temperature increases. These results demonstrate a strategy that can be used to functionalize traditionally non-stimuli responsive biomaterials suitable for on-demand drug delivery systems (DDS).

  PublisherOA PDFDOI

Recent grants

• Novel Zinc-Nanocomposite Materials for Pediatric Bioresorbable Cardiovascular Stents

  NIH · $1.6M · 2019–2025

Frequent coauthors

• Benjamin M. Wu

  Samueli Institute

  51 shared

• Shuaihang Pan

  University of Utah

  21 shared

• Jingke Liu

  University of California, Los Angeles

  19 shared

• Xiaochun Li

  Samueli Institute

  17 shared

• Zeyi Guan

  17 shared

• Xiaochun Li

  University of California, Los Angeles

  9 shared

• Yuxin Zeng

  9 shared

• Gongcheng Yao

  Nanjing Drum Tower Hospital

  8 shared

Education

• Ph.D., Bioengineering

  University of California Los Angeles

  2015

• M.S., Bioengineering

  University of California Los Angeles

  2009

• B.S., Bioengineering

  California Lutheran University

  2008

Awards & honors

• Extramural Loan Repayment Award, NIH | NHLBI (2020-2022)
• Dissertation Year Fellowship, UCLA (2014)