About

Clarel Antoine, MD, is a clinical professor in the Department of Obstetrics and Gynecology at NYU Grossman School of Medicine. His specialties include Obstetrics and Gynecology, with a focus on conditions such as abnormal pap test results, fibroids, menopause, recurrent miscarriage, and pregnancy-related issues. He treats adult patients and is fluent in English, French, Haitian Creole, and Spanish. Dr. Antoine's research interests center on placental and cesarean-related conditions, including placenta accreta/percreta/increta (Morbidly adherent placenta), cesarean scar pregnancy, and maternal morbidity associated with cesarean sections. His work involves evaluating surgical techniques during cesarean delivery, documenting operative procedures through video recordings, and studying the impact of surgical methods on maternal outcomes. He has contributed to understanding the incidence of placental adherence disorders in relation to the number of previous cesarean deliveries and aims to improve surgical practices to reduce long-term complications. His academic credentials include fellowships in Maternal Fetal Medicine at NYU Medical Center and Bellevue Hospital Center, and he completed his residency at Columbia Presbyterian Medical Center. Dr. Antoine is board-certified by the American Board of Obstetrics & Gynecology.

Research topics

• Medicine
• Multimedia
• Gynecology
• Environmental health
• Biology
• Obstetrics
• Internal medicine
• Surgery

Selected publications

• Endometrium-free closure technique for hysterotomy incision at cesarean delivery

  American Journal of Obstetrics and Gynecology · 2026-01-01 · 1 citations

  article1st authorCorresponding
  PublisherDOI

• Endometrium-Free Closure Technique During Cesarean Delivery for Reducing the Risk of Niche Formation and Placenta Accreta Spectrum Disorders

  Obstetrics and Gynecology · 2025-01-09 · 10 citations

  article1st authorCorresponding

  OBJECTIVE: To examine the prevalence and severity of postcesarean residual niche, evaluated using saline infusion sonohysterography, in an expanded cohort of women with one prior cesarean delivery and to assess the effect of uterine closure technique on the risk of placenta accreta spectrum (PAS) disorders. METHODS: This secondary analysis includes 70 patients who underwent saline infusion sonohysterography after one prior cesarean delivery. Patients were grouped according to hysterotomy closure technique: two-layer endometrium-free closure (technique A), and two- or one-layer routine closures (technique B). Niche dimensions and residual myometrial thickness were measured. The primary outcome was clinically significant niche (depth larger than 2 mm), a risk factor for PAS. Groups were compared using χ 2 , unpaired t test, Kruskal-Wallis, and logistic regression with significance at P <.05. RESULTS: There were 33 patients in the technique A group and 37 patients in the technique B group. Technique A was associated with smaller niche dimensions ( P =.018 for width, .005 for depth, and .002 for length), and exhibited thicker residual myometrial thickness (8.5 mm vs 5.5 mm, P =.041) and a lower incidence of clinically significant niches. The odds of having a clinically significant niche were 27 times higher in the technique B group (adjusted odds ratio 27.1, 95% CI, 4.35-168.81, P <.001). CONCLUSION: Uterine closure techniques are associated with the development and size of postcesarean residual niches, which are critical risk factors for PAS disorders. Use of an endometrium-free closure technique during primary cesarean delivery is associated with a reduced risk of future niche formation and PAS complications.

  PublisherDOI

• The broadening spectrum of niche and insights for improved outcomes

  American Journal of Obstetrics and Gynecology · 2025-02-07 · 1 citations

  letter1st authorCorresponding
  PublisherDOI

• Beyond single- vs double-layer closure: optimizing uterine repair in cesarean delivery with endometrium-free technique

  American Journal of Obstetrics and Gynecology · 2024-10-18 · 3 citations

  letter1st authorCorresponding
  PublisherDOI

• Clinical potential of human amniotic fluid stem cells

  Journal of Perinatal Medicine · 2024-01-02 · 1 citations

  articleOpen access
  PublisherOA PDFDOI

• Reply to: “Optimal closure of the uterus during cesarean section: beyond the two layers” commenting on “The effect of uterine closure technique on cesarean scar niche development after multiple cesarean deliveries”

  Journal of Perinatal Medicine · 2024-01-29

  letterSenior author
  PublisherDOI

• Pathophysiology of Long-Term Post-Cesarean Complications: Novel Insight from Tissue Magnification Video-Recording

  Reproductive Medicine Gynaecology & Obstetrics · 2023-03-17

  articleOpen access1st authorCorresponding

  Just over one century ago, the Cesarean operation was almost exclusively performed on a dead or dying mother to remove an infant, either dead or alive. During this time, it was avoided because of its high mortality rate [1].

  PublisherDOI

• The effect of uterine closure technique on cesarean scar niche development after multiple cesarean deliveries

  Journal of Perinatal Medicine · 2023-12-11 · 14 citations

  articleSenior author

  OBJECTIVES: To use saline infusion sonohysterography (SIS) to evaluate the effect of uterine closure technique on niche formation after multiple cesarean deliveries (CDs). METHODS: Patients with at least one prior CD were evaluated for niche via SIS. Subgroups of any number repeat CD (>1 prior), lower-order CD (<4 prior), and higher-order CD (≥4 prior) were analyzed, stratifying by hysterotomy closure technique at last cesarean preceding imaging; techniques included Technique A (endometrium-free double-layer closure) and Technique B (single- or double-layer routine endo-myometrial closure). Niche defects were quantified (depth, length, width, and residual myometrial thickness). The primary outcome was clinically significant niche, defined as depth >2 mm. Statistical analysis was performed using chi-square, ANOVA, t-test, Kruskal-Wallis, and multiple logistic regression, with p-values of <0.05 were statistically significant. RESULTS: A total of 172 post-cesarean SIS studies were reviewed: 105 after repeat CDs, 131 after lower-order CDs, and 41 after higher-order CDs. Technique A was associated with a shorter interval to imaging and more double-layer closures. Technique B was associated with more clinically significant niches across all subgroups, and these niches were significantly longer and deeper when present. Multiple logistic regression demonstrated a 5.6, 8.1, and 11-fold increased adjusted odds of clinically significant niche following Technique B closure in the repeat CD (p<0.01), lower-order CD (p<0.001), and higher-order CD (p=0.04) groups, respectively. CONCLUSIONS: While multiple CDs are known to increase risk for niche defects and their sequelae, hysterotomy closure technique may help to reduce niche development and severity.

  PublisherDOI

• A new era in teaching: how advanced optical recording technology could change the postcesarean delivery complication conundrum

  American Journal of Obstetrics & Gynecology MFM · 2022-09-14 · 2 citations

  article1st authorCorresponding
  PublisherDOI

• Clinical potential of human amniotic fluid stem cells

  Journal of Perinatal Medicine · 2022-08-20 · 3 citations

  articleOpen access

  OBJECTIVES: To determine whether amniotic fluid derived stem cells maintain their stem cell characteristics (a) after processing by a licensed cell therapy center and (b) after the cells undergo simulated clinical application. METHODS: Amniotic fluid was collected by laparotomy - a small uterine incision was made at proposed site for delivery and a sterile catheter inserted to collect fluid into a sterile bag. After flow stopped the catheter was withdrawn, the cesarean completed and the collected fluid delivered to the cell therapy center for processing and cryostorage. A clinical setting was simulated where amniotic fluid cells received from cell therapy center were thawed at room temperature for a maximum of 3 h and passed through a clinical cell delivery device to monitor cell viability. The cells were examined for viability, stability, growth, differentiation, and markers of stemness. RESULTS: Amniotic fluid stem cells processed from a clinical cell therapy center behave similarly to amniotic fluid stem cells processed in a research laboratory with respects to viability, stability, growth, differentiation and maintain markers of stemness. There were differences due to heterogeneity of samples which were not methodological. Growth in cell culture and differentiation were satisfactory. Simulation of treating the cells in a clinical environment show a general stability in viability of amniotic fluid cells at room temperature for 3 h minimum and when passed through a clinically approved delivery device. CONCLUSIONS: The data indicate human amniotic fluid processed in a clinical facility could be used therapeutically if proven to be safe.

  PublisherOA PDFDOI

Frequent coauthors

• Bruce K. Young

  NYU Langone Health

  31 shared

• Frank Silverman

  Toronto Public Health

  20 shared

• Jeannie Wasserman

  New York University

  13 shared

• Joseph Suidan

  American University of Beirut Medical Center

  13 shared

• I Lustig

  Columbia University Irving Medical Center

  8 shared

• Ilan E. Timor‐Tritsch

  New York University

  7 shared

• M. Alba Greco

  5 shared

• Gordon C. C. Douglas

  San Jose State University

  5 shared