About

Shazia Mehmood Siddique, MD, MSHP, is an Assistant Professor of Medicine (Gastroenterology) at the Hospital of the University of Pennsylvania. Her clinical expertise includes gastrointestinal bleeding and iron deficiency anemia. Her research focuses on health services research, with particular emphasis on health equity, clinical guideline development, and the impact of artificial intelligence on gastroenterology practice. She holds a BS in History and Political Science from Drexel University, an MD from Robert Wood Johnson Medical School, and an MSHP in Health Policy Research from the University of Pennsylvania. Siddique is actively involved in research related to racial and ethnic health disparities, evidence-based guidelines, and healthcare utilization, contributing to the academic discourse through multiple publications.

Research topics

• Internal medicine
• Medicine
• Virology
• Gastroenterology
• Medical physics
• Family medicine

Selected publications

• Inflammation’s Impact on Ferritin in Iron Deficiency—Reply

  JAMA Internal Medicine · 2026-01-05

  articleSenior author
  PublisherDOI

• Association of Race and Ethnicity with Healthcare Utilization for Inflammatory Bowel Disease in the United States: A Retrospective Cohort Study.

  UNC Libraries · 2026-04-02

  articleOpen access

  INTRODUCTION: Advances in medical and surgical therapy have improved the outlook for those affected with Crohn's disease and ulcerative colitis; however, it is unclear if Americans from marginalized racial and ethnic backgrounds have adequate and equitable access to care for inflammatory bowel disease. We evaluated the association between race and ethnicity and healthcare utilization in patients diagnosed with inflammatory bowel disease. METHODS: This study identified children and adults diagnosed with inflammatory bowel disease in two national data sets from 2016 to 2017. We modeled the association between healthcare utilization and racial and ethnic subpopulations across different age groups using generalized estimating equations adjusted by disease and socioeconomic factors. RESULTS: Among working-age adults, Black Americans had higher emergency department, hospitalization, and steroid use than White patients, however these differences were attenuated after adjusting for socioeconomic factors. Asian and Hispanic Americans were less likely to receive outpatient gastroenterological care and medical therapy even after adjustment. Emergency department use was more likely among elderly Black patients. Hispanic children had increased healthcare utilization for inflammatory bowel disease compared to White children, though these results did not meet statistical significance. DISCUSSION: Healthcare utilization for long-term management of inflammatory bowel disease is lower in historically marginalized racial and ethnic groups compared to White Americans. Further research is needed to identify and address modifiable patient, clinician, and healthcare system barriers to achieve health equity in the management of inflammatory bowel disease.

  PublisherDOI

• AGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy

  Gastroenterology · 2025-03-20 · 41 citations

  reviewOpen access
  PublisherOA PDFDOI

• Strategies to Promote Health Equity in Professional Society Clinical Guidance in Gastroenterology

  Gastroenterology · 2025-10-20

  article1st authorCorresponding
  PublisherDOI

• The Affordable Care Act Improves Access, Survival, and Racial Disparities of Patients With Liver Disease: A Systematic Review

  Clinical Gastroenterology and Hepatology · 2025-07-07

  reviewOpen access
  PublisherOA PDFDOI

• Perspectives on Racial and Ethnic Health Equity in Systematic Reviews and Evidence-Based Guidelines

  Annals of Internal Medicine · 2025-10-27 · 3 citations

  article

  Evidence synthesis and guideline groups have the potential to address health disparities. In June 2024, the Agency for Healthcare Research and Quality (AHRQ) and the Robert Wood Johnson Foundation (RWJF) cosponsored a summit to address racial and ethnic health equity in systematic reviews and other syntheses and guidelines, with support from Cochrane US. This article summarizes cross-cutting themes around future directions for systematic reviews and guidelines. Discussions addressed include the rationale for addressing racial health equity in systematic reviews and guidelines; representation of people with lived experience in systematic reviews and guidelines; approaches to developing and addressing equity-focused scope, including frameworks, methods, and thoughtful interpretation in systematic reviews; challenges and opportunities for guideline recommendations; need for standardized language and reporting for race and ethnicity in primary research studies, systematic reviews, and guidelines; and measures to track the progress of incorporating and addressing racial and ethnic health equity in systematic reviews and guidelines. Participants acknowledged that a one-size-fits-all approach was not possible or desired. Consensus priorities for next steps were to develop methods guidance to address equity in systematic reviews and guidelines; develop measures to track the progress of addressing racial and health equity in systematic reviews and guidelines; operationalize engaging representative interest holders in systematic reviews and guidelines; and share resources and learning for advancing health equity.

  PublisherDOI

• Frequency and Association of Dyslipidemia with Clinical and Biochemical Parameters among Patients with Non-alcoholic Fatty Liver Disease

  Pakistan Journal of Health Sciences · 2025-12-31

  articleOpen access

  Non-alcoholic fatty liver disease (NAFLD) is increasingly associated with metabolic disorders, particularly dyslipidemia, which contributes to cardiovascular risk and disease progression. Understanding this relationship is essential for early intervention. Objectives: To assess the frequency of dyslipidemia and its association with clinical and biochemical parameters in NAFLD patients. Methods: A cross-sectional study was carried out at the Department of Medicine, Jinnah Hospital, Lahore, from November 2024 to April 2025. A total of 116 ultrasonographically confirmed NAFLD patients aged 18–70 years were registered using non-probability consecutive sampling. Patients with secondary causes of liver disease, lipid-altering medications, or systemic illnesses were excluded. Results: Among the 116 NAFLD participants, the average age was 48.67 ± 11.57 years, and the mean body mass index (BMI) was 28.27 ± 4.60 kg/m². Dyslipidemia was present in 72 (62.1%) of participants. Females comprised 44 (61.1%) of the dyslipidemic group, and 44 (61.1%) were aged 46–70 years. Diabetes mellitus and ischemic heart disease were significantly associated with dyslipidemia (p=0.016 and p=0.004, respectively). Biochemical markers, including BMI (p=0.002), AST (p=0.012), and ALT (p=0.041), were significantly elevated in dyslipidemic patients. Lipid profile abnormalities, such as total cholesterol, triglycerides, and LDL-C, were significantly higher, while HDL-C was lower (all p<0.001). Dyslipidemia prevalence increased with NAFLD severity grade (p<0.001). Conclusion: Dyslipidemia is prevalent in NAFLD and significantly correlates with disease severity and metabolic comorbidities, highlighting the need for integrated lipid and hepatic assessment in clinical management.

  PublisherOA PDFDOI

• Mo1236: THE USE OF RACE & ETHNICITY IN CLINICAL PRACTICE GUIDELINES IN GASTROENTEROLOGY: A SYSTEMATIC REVIEW

  Gastroenterology · 2025-05-01

  reviewSenior author
  PublisherDOI

• Shifts in Cohort Eligibility With Deimplementation of Race-specific Guidance for Hepatocellular Carcinoma Surveillance

  Gastro Hep Advances · 2025-08-25

  articleOpen accessSenior authorCorresponding

  Background and Aims: Clinical guidance for hepatocellular carcinoma (HCC) surveillance for patients with chronic hepatitis B virus (HBV) recently removed race from eligibility criteria, and replaced it with country of origin from a HBV-endemic country and PAGE-B score greater than 10. This study sought to determine adherence to prior race-based guidance and how demographic cohort eligibility would shift using new criteria. Methods: This was a retrospective cohort study of patients with chronic HBV with an outpatient office visit at our institution from June 1, 2022, to June 1, 2023. Patients with a personal history of cirrhosis, HCC, or comorbid viral hepatitis were excluded. HCC surveillance practices were extracted using chart review. PAGE-B scores were calculated utilizing lab data within 3 months of the office visit. Cohort eligibility for screening was compared using criteria from each guidance document. Descriptive and comparative statistics were conducted in Python. Results: Two hundred fifty-nine patients were included (51% Asian, 27% Black, and 12% White). Sixty percent (n = 156) of patients were eligible for surveillance under the race-based guidance, and clinicians adhered to this guidance by ordering surveillance in 94% of eligible cases. Under the new nonrace-based guidance, 63% would be eligible for surveillance, with discordance in surveillance eligibility in 28% of cases. Of patients who would no longer be eligible for HCC surveillance, 97% were Black. Fifty-three percent of patients who would newly warrant surveillance were White, and eligibility was primarily driven by PAGE-B score. Conclusion: Clinicians had been largely adherent to the race-based guidance. New guidance would shift cohort eligibility toward White patients, primarily due to PAGE-B criteria, with 97% of Black patients becoming no longer eligible.

  PublisherOA PDFDOI

• Impact of Artificial Intelligence on the Gastroenterology Workforce and Practice

  Clinical Gastroenterology and Hepatology · 2025-05-13

  articleSenior author
  PublisherDOI

Recent grants

• Evaluation of variability in care and outcomes for patients with gastrointestinal bleeding

  NIH · $851k · 2020–2026

Frequent coauthors

• Shivan J. Mehta

  University of Pennsylvania

  32 shared

• Yngve Falck‐Ytter

  Case Western Reserve University

  30 shared

• Shahnaz Sultan

  University of Minnesota

  25 shared

• Nikhil K. Mull

  University of Pennsylvania Health System

  24 shared

• Brian F Leas

  Kleijnen Systematic Reviews (United Kingdom)

  20 shared

• Siddharth Singh

  20 shared

• Meghan B. Lane‐Fall

  University of Pennsylvania

  20 shared

• Amy Y. Tsou

  National Institute of Neurological Disorders and Stroke

  14 shared

Labs

• Shazia Mehmood Siddique LabPI