About

Eric Low is an Assistant Clinical Professor of Medicine at UC San Diego. His research primarily focuses on gastroenterology, with particular attention to esophageal disorders such as achalasia and eosinophilic esophagitis. He has contributed to numerous publications in these areas, including randomized controlled trials and studies on esophageal anatomy, physiology, and diagnostic techniques. His work involves developing and validating clinical cohorts, evaluating therapeutic interventions, and exploring the epidemiology and pathophysiology of gastrointestinal diseases. Low's research aims to improve diagnostic accuracy and treatment strategies for esophageal conditions, utilizing advanced tools like high-resolution manometry and functional lumen imaging probes.

Research topics

• Internal medicine
• Medicine
• Gastroenterology
• Environmental health
• Oncology
• Radiology
• Cardiology
• Nuclear medicine

Selected publications

• Randomized Controlled Trial of Upper Esophageal Sphincter Assist Device in Laryngopharyngeal Reflux Disease

  Clinical Gastroenterology and Hepatology · 2025-12-01

  article
  PublisherDOI

• Mo1223: LOW ESOPHAGEAL BIOPSY RATES DURING INDEX FOOD IMPACTION RESULT IN DELAYED DIAGNOSIS AND POTENTIAL MISSED CASES OF EOSINOPHILIC ESOPHAGITIS: ANALYSIS FROM A NATIONAL SAMPLE OF VETERANS

  Gastroenterology · 2025-05-01

  article1st authorCorresponding
  PublisherDOI

• Sa1263: WORSENING AIR QUALITY INDEX IS ASSOCIATED WITH EOSINOPHILIC ESOPHAGITIS AS COMPARED TO GASTROESOPHAGEAL REFLUX DISEASE

  Gastroenterology · 2025-05-01

  article1st authorCorresponding
  PublisherDOI

• S1003 Endoscopic Severity, Unlike Histology, Is Associated With Increasing Age in EoE Pediatric, Adolescent, and Adult Patients at Baseline: Pooled Post-Hoc Analysis of Phase 3 KIDS and TREET Clinical Trials

  The American Journal of Gastroenterology · 2025-10-01

  article

  Introduction: Eosinophilic esophagitis (EoE) is a type 2 inflammatory disease affecting the esophagus in all ages. Features of EoE improved significantly following dupilumab treatment, an antibody blocking Interleukin-4 and -13, confirming common pathophysiology across ages. Research suggests disease severity may differ by age. To assess this, we investigated associations between age and disease characteristics using combined data from 2 phase 3 trials. Methods: This is a post-hoc analysis from the EoE KIDS (NCT04394351) and LIBERTY EoE TREET (NCT03633617) trials. Non-age-based inclusion/exclusion criteria were similar, apart from a minimum dysphagia requirement in TREET, not required in KIDS. Patient demographics, prior treatments, and EoE disease characteristics were assessed in 3 subgroups: pediatric (≥1-<12 years); adolescent (≥12-<18 years); adult (≥18 years). Regression analyses using age as a continuous variable evaluated the impact of a 1-year increase in age on each variable. Parameter estimate size indicated the strength of the relationship; positive/negative indicated the direction of the association. Results: Younger age was associated with greater likelihood of male sex (parameter estimate: -0.024 [95% confidence interval: -0.037 to -0.010]; P < 0.001), having ≥1 concurrent type 2 inflammatory disease (-0.043 [-0.060 to -0.025]; P < 0.0001), and having a food elimination diet (-0.040 [-0.054 to -0.026]; P < 0.0001). Endoscopic severity, as assessed by Endoscopic Reference Score total score, increased with age (0.016 [0.006-0.026]; P < 0.01), but the relationship was not consistent across fibrostenotic and inflammatory subscores. Inflammatory features edema and exudates decreased with increasing age (-.004 [-0.006, -0.002]; P < 0.001, -0.008 [-0.006, -0.002]; P < 0.001, respectively), and fibrostenotic features rings and stricture increased with increasing age (0.023 [0.019, 0.028]; P < 0.0001, 0.008 [0.005, 0.010]; P < 0.0001). The likelihood of having a prior history of esophageal dilation also increased with increasing age (0.078 [0.060-0.095]; P < 0.0001). Histologic features were not significantly associated with age. Conclusion: In this pooled analysis of EoE KIDS and LIBERTY EoE TREET, associations between age and clinical/disease-related characteristics of EoE were observed. While baseline histologic features were similar across all ages, fibrostenotic endoscopic features and prior esophageal dilations were more common with increasing age, with inflammatory features more common in younger patients.

  PublisherDOI

• Weight Gain Following Peroral Endoscopic Myotomy for Achalasia Is Associated With Post–Peroral Endoscopic Myotomy Gastroesophageal Reflux Disease

  Clinical Gastroenterology and Hepatology · 2025-11-01

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  PublisherDOI

• Tu1276: UPPER ESOPHAGEAL SPHINCTER DISTENSIBILITY ON IMPEDANCE PLANIMETRY (FLIP) IS ELEVATED IN AEROESOPHAGEAL REFLUX

  Gastroenterology · 2025-05-01

  article1st authorCorresponding
  PublisherDOI

• S1004 Predictors of Low Esophageal Biopsy Rates During Endoscopy for Food Impaction and Resultant Delayed Diagnosis and Missed Cases of Eosinophilic Esophagitis in a National Veteran Population

  The American Journal of Gastroenterology · 2025-10-01

  article1st authorCorresponding

  Introduction: Best practice guidelines recommend obtaining esophageal biopsies during an index food impaction to evaluate for eosinophilic esophagitis (EoE). We performed a retrospective study using a national sample to evaluate rates of esophageal biopsy during an index foreign body/food impaction and assess outcomes related to EoE diagnoses. Methods: We utilized national Veterans Affairs (VA) data to identify adults ≥18 years of age diagnosed with a first esophageal foreign body (FB) (International Classification of Diseases [ICD]-9 and -10 codes) or food impaction (FI) (ICD-10 codes) between January 1, 2008 (first ICD codes for EoE) and December 31, 2023. Diagnoses of esophageal cancer were excluded. Descriptive statistics characterizing biopsy rates and time to EoE diagnosis were performed. Multivariable regression analyses were used to evaluate factors associated with obtaining biopsies. Results: Four thousand five hundred forty-seven unique patients in the Veterans Health Administration (median age 68, 96% men, 81% White) underwent an esophagogastroduodenoscopy (EGD) for an index esophageal FB/FI. Esophageal biopsies were collected in 28.5% (2,153/7,547) of these patients. Ten point three percent (778/7,547) of patients had biopsies documented from multiple esophageal levels. Biopsy frequency was significantly higher following the EoE guidelines in 2018 (31.1%) compared to previous years (26.7%) (P < 0.0001). Ten percent (755/7,547) of the cohort had a diagnosis of EoE: 38% diagnosed at the time of index FB/FI, and 62% after presentation. Median delay in EoE diagnosis was 103 days from index FB/FI (Q1-Q3: 39-473 days). 43.1% (3,256/7,547) of the total cohort never had documented esophageal biopsies collected during their lifetime in the VA system. In multivariable analyses, younger age, performing an “overnight” vs “daytime” endoscopy, male vs female sex, and lower VA facility complexity were associated with obtaining biopsies. Race, ethnicity, and use of propofol during the procedure did not significantly impact biopsy rates. Conclusion: In a national sample, less than 1 in 3 patients presenting with an index FB/FI and who underwent an EGD had esophageal biopsies obtained during the procedure. Older patients and women were at higher risk for not having biopsies collected. More than half of EoE cases were diagnosed after this index presentation, with a median delay in diagnosis of 103 days. Almost 1 in 2 FB/FI patients never had esophageal biopsies collected, suggesting hundreds of EoE cases may have been missed. Adherence to the best practice recommendation of obtaining esophageal biopsies during index FI may improve EoE diagnosis timing and initiation of treatment.

  PublisherDOI

• Dupilumab Efficacy In Adolescents And Adults With Eosinophilic Esophagitis With And Without Concurrent Elimination Diet: Post Hoc Analysis Of LIBERTY EoE TREET At 52 Weeks

  Journal of Allergy and Clinical Immunology · 2025-02-01

  articleOpen access
  PublisherOA PDFDOI

• The First Approved Therapy in Infants and Young Children With Eosinophilic Esophagitis — Now the Big Question: Where Will Dupilumab Fit Into Real-World Practice?

  Gastroenterology · 2024-10-10

  article1st authorCorresponding
  PublisherDOI

• WEIGHT GAIN FOLLOWING PERORAL ENDOSCOPIC MYOTOMY (POEM) FOR ACHALASIA IS ASSOCIATED WITH POST-POEM GASTROESOPHAGEAL REFLUX DISEASE

  Gastrointestinal Endoscopy · 2024-06-01 · 1 citations

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  PublisherDOI

Frequent coauthors

• Rena Yadlapati

  University of California, San Diego

  35 shared

• Lin Liu

  22 shared

• Samir Gupta

  Moores Cancer Center

  19 shared

• Hannah Caldwell

  Royal Australasian College of Surgeons

  16 shared

• Lynda Wyld

  16 shared

• Katja Felgentraeger

  Royal Australasian College of Surgeons

  16 shared

• Julie Glanville

  16 shared

• Everth Merida-Herrera

  Cambridge University Press

  16 shared

Education

• M.D.

  University of California, San Diego

• B.S.

  University of California, San Diego