Beyond the Prostate: Incidental Detection of Male Breast Carcinoma on [ ¹⁸ F]DCFPyl

Journal of Nuclear Medicine · 2025-12-18

Prostate-specific membrane antigen (PSMA) is consistently expressed in tumor neovasculature but variably in tumor cells, with prior reports demonstrating PSMA uptake in invasive ductal carcinoma in men ([1][1]). This case reinforces the value of PSMA in characterizing breast cancer in men,

Heart Disease Prediction Using Knowledge Graphs

2025-04-09

This work demonstrates how to improve the prediction of heart illness by integrating ML models with knowledge graphs. By leveraging knowledge graphs to represent the relational structure among clinical and demographic features, the proposed framework improves the interpretability and predictive accuracy of traditional machine learning techniques. A GNN is employed to process the enriched feature set, capturing complex interdependencies and patterns in the data. The dataset, consisting of 1,025 patient records, was preprocessed and used to train and validate multiple models, including Logistic Regression, Decision Tree, Random Forest, and GNN. Results demonstrate that the Random Forest and Decision Tree outperforms traditional models, achieving a test accuracy of 98.5% while maintaining high precision and recall. Our Research highlights the potential of combining knowledge graphs with modern ML methods to address complex challenges in medicine, opening up the way to more reliable and interpretable diagnostic tools.

Orchestrating autoimmune diseases through nuclear receptors and orphan GPCRs

2025-07-28

ALLOGENEIC, OFF THE SHELF, POOLED, BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS (STEMPEUCEL®) – RESULTS: FROM PIVOTAL TRIALS OF A COMMERCIALLY APPROVED THERAPY IN INDIA FOR GRADE II & III OSTEOARTHRITIS KNEE

Osteoarthritis and Cartilage · 2025-04-01

Toxicity of fungicides

Elsevier eBooks · 2025-01-01 · 8 citations

Structure-Based Drug Design for Tuberculosis

Apple Academic Press eBooks · 2025-10-15

Structure-based drug design (SBDD) is one of the advanced techniques of computeraided drug design used to expedite the drug discovery process. Tuberculosis (TB) is one of the therapeutic areas where the discovery of novel therapeutics—and the use of existing therapeutics—is still challenging due to microbial drug resistance (MDR). SBDD techniques are being utilized to exploit various therapeutically viable anti-TB targets to obtain novel scaffolds, such as RNA polymerase, enoyl-acyl protein reductase, DprEl, DprE2, MmpL3, MmpL7, QcrB, topoisomerase II complex (DNA gyrase), EmbC [arabinogalactan (AG) and lipoarabinomannan (LAM)], EthR2, F-ATP synthase, ketomycolic acid, and methoxy mycolic acid synthesis. The inspiring journey of the life-saving anti-TB drug Bedaquiline (TMC207) against MDR TB began with the screening of a 70,000-compound library against the F-ATP synthase of a non-pathogenic TB strain, followed by subsequent SBDD efforts. Moreover, the nitroimidazole derivatives Delamanid and Pretomanid were discovered through scaffold modification and high-throughput screening. The benzothiazinone derivative Macozinone was discovered through a lead optimization campaign targeting DprEl inhibitors. Several successful SBDD studies have been reported in recent years, facilitating the discovery of novel anti-TB agents. In this chapter, SBDD approaches are discussed in connection with the discovery and optimization of anti-TB drugs.

Organoid: Biomedical application, biobanking, and pathways to translation

Heliyon · 2025-02-26 · 10 citations

Organoids are tiny stem cell-derived 3D in vitro cell culture systems mimicking the structural and functional aspects of the tissues in the human body and provide a means to study complex bio-physiological processes in normal and disease states (disease modeling) and also for therapeutic screening and clinical trials. Scientists have now developed protocols to maintain and use organoids from diverse human tissues, including the gut, liver, brain, and pancreas, and they have the potential to reduce or remove the dependency on animal models and have research utility and translational potential. One major advantage is that they can be generated from patients with specific genetic diseases, thereby providing options for exploring personalized medicine and rare diseases lacking robust animal models. Recent advances in multi-omics technologies, imaging technologies, biomaterial chemistry, bioengineering, microfluidics, and stem cell research have revolutionized organoid bioengineering, opening the opportunity for mass production, biobanking, and commercialization.

Towards an Indic Conceptual Framework of Sustainability: Yajña, Saha-astitva and the Jajmāni Paradigm

Journal of Human Values · 2025-08-14

It is now increasingly acknowledged that modern lifestyle can no longer be sustained on the planet. The success of modernity has landed humanity in the ‘development paradox’, where human progress threatens human survival. However, the predominant discussion on sustainability primarily centres around elongating the modern lifestyle, based on Western values of materialism, individualism and consumerism. It is also evident that the lingering problems of our times cannot be resolved within the prevalent worldview heavily loaded with materialism. Therefore, there is a need for a paradigm shift. In this regard, India can provide answers to develop an alternative framework of sustainability. This study attempts to situate two important philosophical concepts, namely yajña and saha-astitva , amidst the contemporary discussions on sustainability. This study also draws upon important learnings from traditional Indian villages. To study the functioning of traditional villages (or jajmāni system) from the perspective of sustainability is a novel attempt.

When PSMA lights up the thyroid: an incidental discovery of a second primary on [68Ga]Ga-PSMA-11

European Journal of Nuclear Medicine and Molecular Imaging · 2025-06-05

Complications of Diabetics in SARS-COVID patients

International Journal of Medical Pharmaceutical and Health Sciences (IJMPHS). · 2024-03-25