Joshua P. Metlay
VerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 1984–2025
Research topics
- Medicine
- Internal medicine
- Emergency medicine
- Intensive care medicine
- Family medicine
Selected publications
Journal of General Internal Medicine · 2025-11-17 · 5 citations
articleOpen accessMACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA.
PubMed · 2025-01-01
articleOpen access1st authorCorrespondingthreatened to render standard empiric antibiotic therapy ineffective. One of the biggest drivers of pneumococcal drug resistance is antibiotic overuse, among both adults and children. While the introduction of the pneumococcal conjugate vaccine in 2000 dramatically impacted the overall incidence of pneumococcal pneumonia in both children and adults, the levels of antibiotic resistance have remained significant. To reduce the overuse of antibiotics requires multidimensional interventions targeting patients, clinicians, and health systems. Studies have demonstrated improvement in this area, but the quality gap remains high. Future work will focus on organizational strategies and policies that optimize antibiotic use for patients with antibiotic responsive acute illnesses.
Agreement Between Telehealth and In-Person Evaluations of Patients with Acute Respiratory Infections
Telemedicine Journal and e-Health · 2025-11-10
article1st authorCorrespondingHow the absence of a physical examination in telehealth visits influences clinical decision-making in telehealth visits is not known. The aim of this study was to examine whether provision of patient self-collected vital signs influences telehealth management decisions for acute respiratory tract infections (ARIs). A consecutive sample of adult patients seeking care for ARIs completed a simulated telehealth visit either before or after their scheduled in-person evaluation. Patients were given instructions and devices to collect their vital signs before the telehealth visit. We compared the telehealth physician diagnostic and treatment recommendations with those made by the in-person treating physician. Forty-five patients completed the study. Compared to the in-person management decisions, telehealth evaluations yielded perfect agreement for when patients needed hospital admission. However, there was significant disagreement around the need for chest imaging and antibiotic treatment, with modest differences following the provision of patient self-collected vital signs.
Procalcitonin in the management of lower respiratory tract infection and sepsis
Journal of Antimicrobial Chemotherapy · 2025-08-09 · 1 citations
articleOpen accessAmerican Journal of Respiratory and Critical Care Medicine · 2025-07-18 · 54 citations
articleBACKGROUND: Understanding of the diagnosis and treatment of adults with community-acquired pneumonia (CAP) has evolved thanks to new evidence, experience, and emerging technologies. This document updates evidence-based clinical practice guidelines on four key questions for the diagnosis and management of adult patients with CAP. METHODS: A multidisciplinary panel integrated systematic reviews of comparative evidence with other relevant research and clinical experience, then applied Grading of Recommendations, Assessment, Development and Evaluation methodology to produce recommendations using the Evidence to Decision Framework. RESULTS: The panel formulated clinical recommendations that address questions related to CAP, including lung ultrasound for diagnosis, empiric antibacterial therapy if a test result for a respiratory virus is positive, antibiotic duration, and the use of systemic corticosteroids. CONCLUSIONS: The panel formulated and provided the rationale for recommendations on selected diagnostic and treatment strategies for adult patients with CAP.
National Survey of Factors Associated with Physician Antibiotic Prescribing Preferences
Journal of General Internal Medicine · 2024-11-25 · 1 citations
articleOpen accessAccuracy of Patient-Collected Vital Signs
Telemedicine Journal and e-Health · 2024-08-16 · 3 citations
article1st authorCorrespondingIntroduction: Telehealth has emerged as an important clinical setting for managing acute respiratory tract infections (ARIs), potentially reducing emergency department and urgent care overcrowding, and reducing nosocomial transmission. Many current algorithms for ARI management incorporate information on patient vital signs. However, the accuracy of vital signs collected by patients using readily available home devices and techniques has not been studied. Methods: A cross-sectional sample of patients seen for urgent conditions at a hospital emergency and urgent care center were given instructions and low-cost, readily available devices to collect their vital signs. A trained research coordinator collected a parallel set of vital signs using standard hospital equipment, serving as the gold standard. We analyzed the performance of patient-collected vital signs compared with vital signs collected by a trained research coordinator. Results: A total of 300 patients completed the study. Patient-collected vital signs were highly specific for traditional levels of abnormalities (HR >100 beats per min, RR >24 breaths per min, temperature >100.4 degrees Fahrenheit, oxygen saturation <94 percent); however, sensitivity was poor for elevated heart rate by pulse estimation (25%) and elevated respiratory rate (60%). Heart rate and oxygen saturation by pulse oximeter and oral temperature had higher sensitivity. Conclusions: Vital signs measured and provided by patients are not uniformly accurate, particularly when using manual techniques rather than automated devices. Telehealth algorithms that rely on these values could provide incorrect triage and management advice.
Implementation of wireless continuous vital sign monitoring after cesarean delivery in uganda
American Journal of Obstetrics and Gynecology · 2023-01-01
articleOpen accessTime to Treat Severe Community-Acquired Pneumonia with Steroids?
New England Journal of Medicine · 2023-05-24 · 7 citations
editorial1st authorCorrespondingGuidelines for the treatment of community-acquired pneumonia (CAP) focus primarily on the choice of antibiotic therapy. However, the 2019 guidelines of the American Thoracic Society and the Infectious Diseases Society of America for adult CAP was the first version to address the role of glucocorticoids as adjunct therapy. The guideline committee (which we cochaired) did not recommend the use of glucocorticoids for most patients with CAP,1 but it did endorse the use of glucocorticoids for adults with refractory septic shock that is resistant to fluid resuscitation and vasopressor support, consistent with the suggested use of these drugs in previously released . . .
Hospital medicine: It's gotten bigger, but can we make it better?
Journal of Hospital Medicine · 2022-10-07
letterSenior authorThe authors declare no conflict of interest.
Recent grants
NIH · $451k · 2011
NIH · $997k · 2012
NIH · $1.0M · 2013
NIH · $5.5M · 2011
NIH · $2.5M · 2013
Frequent coauthors
- 101 shared
Jeffrey S. Gerber
Children's Hospital of Philadelphia
- 93 shared
Jonathan A. Finkelstein
Kaiser Permanente
- 92 shared
David J. Margolis
University of Pennsylvania
- 90 shared
Carlos A. Camargo
Harvard University
- 89 shared
Thomas M. File
- 85 shared
Jeffrey A. Linder
Northwestern University
- 83 shared
Daniel Merenstein
Georgetown University Medical Center
- 82 shared
Rebecca M. Roberts
Centers for Disease Control and Prevention
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