Hao Chen
· ProfessorUniversity of California, Davis · Computer Science
Active 1965–2024
About
Hao Chen is a Professor of Computer Science at the University of California, Davis. His research interests include security, machine learning, and software engineering. Professor Chen's group focuses on applying statistical machine learning techniques to problems in security and program analysis, with particular attention to the robustness and explainability of machine learning models.
Research topics
- Chemistry
- Biology
- Organic chemistry
- Genetics
- Materials science
- Nanotechnology
- Computational biology
- Medicine
- Computer Science
- Internal medicine
- Chemical engineering
- Cell biology
- Composite material
- Anatomy
- Biochemistry
- Virology
- Chemical physics
- Computational chemistry
- Physical chemistry
- Data science
- Engineering
- Neuroscience
- Crystallography
- Combinatorial chemistry
Selected publications
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
Nature Cell Biology · 2023 · 170 citations
- Computational biology
- Cell biology
- Biology
mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly
Physiological Genomics · 2022 · 18 citations
- Computer Science
- Biology
- Computational biology
Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and improved rat reference genome, mRatBN7.2, in late 2020 is a welcome event. This assembly, like predecessor rat reference assemblies, is derived from an inbred Brown Norway rat. In this "user" survey we hope to provide other users of this assembly some insight into its characteristics and some assessment of its improvements as well as a few caveats that arise from the unique aspects of this assembly. mRatBN7.2 was generated by the Wellcome Sanger Institute as part of the large Vertebrate Genomes Project. This rat assembly has now joined human, mouse, chicken, and zebrafish in the National Center for Biotechnology Information (NCBI)'s Genome Reference Consortium, which provides ongoing curation of the assembly. Here we examine the technical procedures by which the assembly was created and assess how this assembly constitutes an improvement over its predecessor. We also indicate the technical limitations affecting the assembly, providing illustrations of how these limitations arise and the impact that results for this reference assembly.
Aging · 2021 · 63 citations
- Cancer research
- Medicine
- Pharmacology
The absence of a gold standard for treating pulmonary fibrosis makes its management challenging. We established a rat model to study the effect of resveratrol (Res) on bleomycin-induced pulmonary fibrosis. Rats were randomly divided into control, model, low-Res, middle-Res, high-Res, and dexamethasone groups and treated with various concentrations of these drugs. Rats showed typical features of pulmonary fibrosis; i.e., alveolitis, fibrous hyperplasia, and fibrosis on days 7, 14, and 28, respectively. Expression of HIF-1α and NF-κB was higher in the middle-Res, high-Res, and dexamethasone groups than in the control group, but was less than that in the model and low Res groups. We conclude that different levels of HIF-1α and NF-κB expression at different stages of pulmonary fibrosis in rats is positively correlated with the disease severity. Furthermore, resveratrol alleviates bleomycin-induced pulmonary fibrosis by suppressing HIF-1α and NF-κB expression, indicating its potential as a promising therapeutic drug candidate.
Nature Communications · 2021 · 480 citations
- Biology
- Genetics
- Computational biology
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.
Advanced Materials · 2021 · 555 citations
- Materials science
- Nanotechnology
- Chemical engineering
coordination structure significantly tailors the electronic structure of Pt 5d states, resulting in promoted reduction of adsorbed proton, facilitated H-H coupling, and thus Pt-like HER activity. This work provides a constructive route for precisely designing single-Pt-atom-based robust electrocatalysts with high HER activity and durability.
Chem · 2020 · 711 citations
- Nanotechnology
- Chemistry
- Materials science
Dynamic Covalent Synthesis of Crystalline Porous Graphitic Frameworks
Chem · 2020 · 196 citations
- Materials science
- Nanotechnology
- Chemical engineering
Potential influence of COVID-19/ACE2 on the female reproductive system
Molecular Human Reproduction · 2020 · 410 citations
- Biology
- Virology
- Internal medicine
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.
Recent grants
NIH · $149k · 2014
NIH · $1.4M · 2018
NIH · $2.5M · 2012
NIH · $287k · 2012
Change-Point Analysis for Multivariate and Object Data
NSF · $342k · 2015–2019
Frequent coauthors
- 5832 shared
Yan Wang
Hunan Agricultural University
- 3933 shared
Wei Wang
Changhai Hospital
- 3888 shared
Yan Wang
Chinese Academy of Medical Sciences & Peking Union Medical College
- 2997 shared
Bo Li
Beijing Institute of Neurosurgery
- 2688 shared
Yang Gao
Fudan University
- 1998 shared
Bo Li
Shanghai Jiao Tong University
- 1512 shared
Hao Sun
Chinese Academy of Medical Sciences & Peking Union Medical College
- 1368 shared
Xiang Li
Xuzhou Medical College
Education
master
Southwest Medical University
Awards & honors
- ACM Distinguished Members (2021)
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