Gustavo S. Guandalini
VerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 2015–2025
About
Gustavo S. Guandalini, MD, is an Assistant Professor of Clinical Medicine in the Department of Medicine at the Perelman School of Medicine, University of Pennsylvania. He completed his MD at the Federal University of Paraná in Curitiba, Brazil, in 2007. His professional focus involves cardiovascular medicine, with particular expertise in cardiac electrophysiology. Dr. Guandalini is involved in research related to atrial fibrillation, ventricular arrhythmias, and cardiac ablation techniques, contributing to advancements in procedural outcomes and safety. His work includes investigating intraoperative nerve blocks during cardiac device procedures, ablation strategies for atrial fibrillation, and the management of arrhythmias in complex patient populations. He actively publishes in peer-reviewed journals, reflecting his commitment to improving clinical interventions and patient care in electrophysiology.
Research topics
- Medicine
- Cardiology
- Internal medicine
- Anesthesia
- Surgery
Selected publications
Heart Rhythm · 2025-04-01
articleHeart Rhythm · 2025-04-01
articleJournal of Interventional Cardiac Electrophysiology · 2025-08-27
articleOpen accessBACKGROUND: Left ventricular (LV) diastolic dysfunction is associated with the development of atrial fibrillation (AF) and risk of recurrence after ablation. The use of an intracardiac echocardiography (ICE) for diastolic function assessment during ablation procedures has not been evaluated. OBJECTIVES: To evaluate the feasibility and utility of ICE obtained measures of LV diastolic function including peak tricuspid regurgitation velocity, trans-mitral flow velocity, mitral annular tissue Doppler velocities, and pulmonary vein flow velocities in patients undergoing AF ablation. METHODS: We conducted a single-center, prospective evaluation of patients undergoing AF ablation between 2022 and 2024. During sinus rhythm, diastolic parameters were measured with the ICE catheter and direct left atrial pressure (LAP) was recorded prior to AF ablation. Elevated LAP was defined as ≥ 12 mmHg. ICE measured diastolic parameters were compared with those measured on transthoracic echocardiography (TTE). RESULTS: -VASc score of 3 ± 2) were analyzed, of which 80 had normal LAP (< 12 mmHg) by direct measurement. Several ICE parameters were found to be significantly associated with mean LAP, including greater peak tricuspid regurgitation velocity (β = 3.5; p = 0.005) and average E/e' (β = 0.7; p < 0.001). In multivariable model, post-procedure intravenous diuretics were more commonly required in patients with abnormal diastolic function by ICE (mitral E/A OR = 8.1; average E/e' OR = 24.2). CONCLUSIONS: ICE can be used to assess diastolic function with traditional parameters correlating with both TTE diastolic function and LAP. ICE measures of restrictive filling are associated with the need for post-procedural intravenous diuretics.
Journal of Cardiovascular Electrophysiology · 2025-06-23 · 3 citations
articleOpen accessBACKGROUND: Long-standing persistent atrial fibrillation (LSPAF) is associated with adverse atrial structural and electrical remodeling, limiting the success of catheter ablation (CA). OBJECTIVE: To determine whether temporary restoration of sinus rhythm (TRSR) can improve the single procedure efficacy of CA in patients with LSPAF. METHODS: Patients with LSPAF undergoing their first CA between 2016 and 2022 were included. TRSR was attempted using cardioversion, with or without antiarrhythmic drugs (AAD), no later than 6 months before CA. The ablation strategy included pulmonary vein isolation (PVI), non-PV trigger ablation, and linear lesions for organized atrial tachyarrhythmias (OAT). The primary study outcome was freedom from atrial arrhythmias (AA: AF and/or OAT) on/off AAD at 12 months, and the secondary outcome was freedom from AA off AAD at 12 months. RESULTS: -VASc score 3.1 vs. 2.7, p = 0.012) than those who did not. The primary and secondary outcomes were significantly better in the TRSR than the no TRSR group: AA-free survival (73% vs. 51%, p = 0.004) and AA-free survival off AAD (69% vs. 45%, p = 0.002). The primary outcome was better in the TRSR group, whether the presenting rhythm at CA was SR or AF (75% and 72%, respectively). CONCLUSIONS: TRSR within 6 months of CA was associated with improved arrhythmia-free survival in LSPAF patients undergoing CA regardless of the presenting rhythm at ablation.
Heart Rhythm · 2025-04-01
articleOpen accessHeart Rhythm · 2025-04-01
articleCI-499643-003 LEFT BUNDLE BRANCH AREA PACING IN PATIENTS WITH CARDIAC SARCOIDOSIS
Heart Rhythm · 2025-04-01
articleHeart Rhythm · 2025-04-01
articleOpen accessLeft Bundle Branch Area Pacing in Patients With Cardiac Sarcoidosis
JACC. Clinical electrophysiology · 2025-11-20 · 2 citations
articleEP Europace · 2025-06-01 · 2 citations
articleOpen accessAIMS: The diagnosis of infiltrative cardiomyopathies has increased over last years. Catheter ablation is becoming the preferred approach for managing atrial fibrillation (AF) in these patients. This study aims to characterize differences in procedural findings during AF ablation in patients with and without infiltrative cardiomyopathies. METHODS AND RESULTS: Patients with cardiac amyloidosis and cardiac sarcoidosis undergoing first-time AF ablation were propensity score matched in 1:4 ratio to separate reference groups that received trigger provocative manoeuvres (isoproterenol infusion and/or atrial burst pacing) and had no prior cardiac surgery. Non-pulmonary vein (PV) triggers [defined as ectopic foci initiating AF or sustained focal atrial tachycardia (AT)] and macro-reentrant atrial flutters (AFLs) were then mapped and targeted. Recurrence was defined as AF/AT/AFL ≥ 30 s after 90-day blanking period. Twenty-four patients with cardiac amyloidosis were matched to 96 controls, and 17 patients with cardiac sarcoidosis were matched to 68 controls. Non-PV triggers were more frequent in patients with cardiac amyloidosis {29.2% vs. 8.3%; odds ratio [OR] = 4.5 [95% confidence interval (CI): 1.4-14.2]} and cardiac sarcoidosis [17.6% vs. 7.4%; OR = 2.7 (95% CI: 0.6-12.6)] compared with their reference groups. Patients with cardiac amyloidosis also had a higher incidence of left atrial macro-reentrant flutters [37.5% vs. 6.3%; OR = 9.0, (95% CI: 2.8-29.0)]. One-year recurrence rate was similar between patients with cardiac sarcoidosis and controls (33.3% vs. 33.9%; P = 0.965) but higher in patients with cardiac amyloidosis vs. controls (47.4% vs. 27.1%; P = 0.049). CONCLUSION: Patients with infiltrative cardiomyopathies exhibit higher rates of non-PV triggers and left AFLs during first-time AF ablation. Those with cardiac amyloidosis experience higher arrhythmia recurrence rates compared with controls.
Frequent coauthors
- 62 shared
Francis E. Marchlinski
- 59 shared
David J. Callans
University of Pennsylvania
- 55 shared
Saman Nazarian
University of Pennsylvania
- 52 shared
Matthew C. Hyman
- 52 shared
David S. Frankel
University of Pennsylvania
- 51 shared
Robert D. Schaller
- 43 shared
Gregory E. Supple
University of Pennsylvania
- 41 shared
Sanjay Dixit
University of Pennsylvania
Education
- 2020
Fellow, Clinical Cardiac Electrophysiology, Electrophysiology Section, Division of Cardiology
Hospital of the University of Pennsylvania
- 2015
Chief Medicine Resident, Internal Medicine
Georgetown University Hospital/Washington Hospital Center
- 2014
Internal Medicine Resident, Medicine
Georgetown University Hospital/Washington Hospital Center
- 2011
Post-Doctoral Research Fellow, Biophysical Toxicology
Armed Forces Institute of Pathology
- 2007
MD
Universidade Federal do Paraná
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Gustavo S. Guandalini
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup