Abstract 4171 Chromatin bivalency as a key determinant of effective cancer therapy

Journal of Biological Chemistry · 2026-05-01

Research trends on lymphedema after mastectomy for breast cancer patients from 2000 to 2023: a scientometric analysis

Frontiers in Oncology · 2025-02-04 · 4 citations

Background: Breast cancer-related lymphedema (BCRL) is a common and debilitating complication following breast cancer treatment. Despite its significant impact on patients' quality of life, bibliometric analyses focusing on BCRL are scarce. This study aims to explore global research trends on BCRL from 2000 to 2023, identify existing knowledge gaps, and highlight emerging focus areas through a bibliometric approach. Methods: A comprehensive search was conducted using the Web of Science (WOS) database to retrieve literature published between January 2000 and November 2023. Bibliometric analyses and visualizations were performed using R Studio, CiteSpace, and VOSviewer. Key data extracted included publication trends, contributing countries and institutions, leading authors, journals, research categories, and keywords. Outcome measures for analysis included the number of publications, citation counts, author productivity, and keyword co-occurrence. Results: " emerging as the journal with the highest citation count. The USA was the most prolific contributor to the field. The annual number of publications demonstrated a consistent upward trend. Keyword co-occurrence analysis revealed prominent research hotspots, including "lymphedema," "women," "breast cancer," "arm lymphedema," and "quality of life." Emerging keyword trends from 2021 to 2023 highlighted "prevention" and "validity" as pivotal research frontiers. Conclusions: This bibliometric study highlights the growing interest in breast cancer-related lymphedema research and identifies key areas for future investigation, including prevention, diagnosis, and treatment strategies. The results underscore the need for further exploration of these emerging research areas to improve patient outcomes.

Graphene quantum dots as supramolecular linkers in metal organic frameworks for constructing metal atom electrocatalysts

Chemical Communications · 2025-01-01 · 2 citations

A new strategy is developed to stabilize single cobalt sites by covalent linking between metal and N-doped graphene quantum dots (N-GQDs) confined within the pores of zeolitic imidazolate frameworks (ZIFs). The incorporation of N-GQDs not only facilitates the formation of abundant active sites but also promotes their accessibility.

Low Voltage Area Modification in Older Patients With Atrial Fibrillation

Pacing and Clinical Electrophysiology · 2025-05-23 · 1 citations

BACKGROUND: Age has been found as an important factor affecting the low voltage area (LVA) in patients with atrial fibrillation (AF). This study aims to investigate the potential benefit of LVA modification in older AF patients. METHODS: This study constitutes a sub-analysis of the STABLE-SR-II and STABLE-SR-III trials, wherein patients with persistent AF (PeAF) or paroxysmal AF (PAF) were randomized to undergo either circumferential pulmonary vein isolation (CPVI) alone or additional LVA modification. Patients aged ≥65 years were analyzed. The primary outcome was freedom from atrial tachyarrhythmias (ATAs). RESULTS: A total of 510 patients (mean age 70.2 ± 3.8 years, 264 male) were analyzed, comprising 96 PeAF and 414 PAF patients. Among patients without LVA, the risk of ATAs recurrence was similar between PeAF and PAF patients in the propensity score-matched model (adjusted HR, 1.49 [0.54-4.33]; p = 0.431). Both PeAF (adjusted HR, 0.35 [95% CI, 0.12-0.98]; p = 0.048) and PAF patients (adjusted HR, 0.41 [0.19-0.81]; p = 0.013) could benefit from additional LVA modification in the Cox proportional hazards model. CONCLUSIONS: In older patients with AF, the recurrence rate following CPVI alone is comparable between those with PAF and PeAF in the absence of LVA. However, the presence of LVA is associated with higher recurrence rates in both PAF and PeAF patients, while additional LVA modification effectively reduces recurrence irrespective of AF type.

Association Between Renal Function and Left Atrial Low‐Voltage Area Burden in Paroxysmal Atrial Fibrillation

Annals of Noninvasive Electrocardiology · 2025-11-01 · 2 citations

ABSTRACT Background Circumferential pulmonary vein isolation (CPVI) plus left atrial low‐voltage areas (LVA) modification is a useful method to treat paroxysmal atrial fibrillation (PAF); however, it is hard to predict LVA burden before the procedure. The existence of chronic kidney disease (CKD) increases the prevalence of left atrial LVA. In this study, we explored the relationship between renal function and the LVA burden in elderly patients with PAF. Methods We retrospectively analyzed the 435 elderly patients with PAF who underwent ablation. Based on the LVA burden measured during the procedure, the patients were divided into four groups: Group 1 (LVA burden ≤ 5%, n = 356), Group 2 (LVA burden 5%–10%, n = 39), Group 3 (LVA burden 10%–15%, n = 16), and Group 4 (LVA burden > 15%, n = 24). Results Increasing LVA burden was associated with a progressive decline in eGFR. A significant difference was observed between Group 1 and Group 4 (86.6 ± 12.9 vs. 76.4 ± 17.7, p = 0.003). eGFR was identified to be a predictor for LVA burden > 10%, with the optimal cut‐off value for GFR being 75.7 mL/min/1.73 m 2 , having a sensitivity of 54.2% and specificity of 80.4%. Conclusions A lower eGFR is associated with higher LVA burden in elderly patients with PAF.

UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

Molecular Cell · 2025-11-20 · 1 citations

Electrophysiological Features of Atrial Tachyarrhythmias and Rhythm Outcome in Patients Receiving Repeat Catheter Ablation after Surgical Atrial Fibrillation Ablation plus Left Atrial Appendage Excision

Cardiology · 2025-08-05

INTRODUCTION: Trans-thoracoscopic atrial fibrillation (AF) ablation combined with left atrial appendage excision (LAAE) is an alternative treatment approach for nonvalvular AF patients with a history of thromboembolic events. The primary objective of this research was to investigate the electrophysiological characteristics of recurrent atrial tachyarrhythmias and rhythm outcome in patients receiving repeat catheter ablation after surgical AF ablation plus LAAE. METHODS: Nonvalvular AF patients with previous thromboembolic events who underwent trans-thoracoscopic AF ablation plus LAAE and then received radiofrequency catheter ablation were enrolled. During the procedure, the reconnection of the left atrium (LA) and pulmonary veins (PVs) was investigated, and three-dimensional activation mapping of the LA and/or right atrium during atrial tachyarrhythmias was performed. RESULTS: From January 2014 to December 2021, 173 patients without a history of prior ablation underwent concurrent trans-thoracoscopic AF ablation and LAAE. A total of 74 patients experienced recurrent atrial tachyarrhythmias during a median follow-up period of 3.5 years (interquartile range [IQR]: 2.0 to 5.0 years) after the surgical procedure. A total of 22 patients with atrial tachyarrhythmias recurrence (11 males, aged 60 ± 9 years) underwent radiofrequency catheter ablation. Among them, 10 patients with recurrent AF were identified, and in two of them, non-PV triggers originated from the interatrial septum and the superior vena cava. Reconnected LA-PV conduction was detected in 12 patients, with a total of 27 PV gaps. Eighteen of these PV gaps were located at the roof or the bottom. Thirteen sustained atrial tachycardias (ATs) were mapped in 12 patients, including peri-mitral AT (n = 7), cavotricuspid isthmus-dependent AT (n = 3), remnant LAA-related micro-reentrant AT (n = 1), roof-dependent reentry AT (n = 1), and focal AT (n = 1). At a median follow-up of 9 months (IQR: 3-20 months) after the ablation procedure, the freedom rate from atrial tachyarrhythmias was 77%. CONCLUSION: Reconnection of LA-PVs and macro-reentry ATs are common in repeat catheter ablation after surgical treatment for AF, with peri-mitral AT being the most frequently observed AT. PV gaps are most often located at the roof or bottom. Additionally, LAAE may contribute to arrhythmogenesis in certain patients. Catheter ablation targeting these mechanisms resulted in a favorable short- to mid-term rhythm outcome.

Stabilizing Lattice Oxygen to Enable Durable MnO ₂ Electrocatalyst for Simultaneous Acidic Hydrogen Production and Biomass Valorization

Angewandte Chemie International Edition · 2025-02-22 · 14 citations

Abstract Understanding and steering the stability of earth‐abundant electrocatalysts in acidic medium is essential for proton exchange membrane (PEM) water electrolyzer. Manganese oxide (MnO 2 ) is one of the promising candidates for acidic oxygen evolution reaction (OER), but it still suffers from the overoxidation and the underlying mechanism remains elusive. Here, we observed that lattice oxygen was involved in the OER process on γ‐MnO 2 via Mars‐van‐Krevelen mechanism. Combined with theoretical calculation, we revealed that the release of lattice oxygen lowers the energy barrier of Mn dissolution and compromises the electrode durability. Based on this finding, we propose a strategy to efficiently stabilize lattice oxygen and suppress Mn overoxidation by replacing OER with glucose oxidation to formic acid, which follows a Langmuir–Hinshelwood mechanism. As a result, the durability of γ‐MnO 2 was enhanced by 1100 times, enabling long stability up to 960 hours. Moreover, we demonstrated a production rate of 487.1 mmol h −1 for formic acid and 16.7 L h −1 for H 2 at 40 A in a PEM electrolyzer, providing a sustainable and scalable route for converting water and biomass into valuable chemicals and fuels.

Electrocatalytic Migratory Carboxylation of Unactivated Olefins or Halides with CO ₂

Angewandte Chemie · 2025-12-01

Abstract Coupling carbon dioxide (CO 2 ) with organic molecules through the electrocarboxylation reaction constitutes a promising approach for generating value‐added carboxylic acids. Up to now, activated substrates (such as styrene and butadiene derivatives) have been predominantly focused on due to their high activity. In contrast, the unactivated substrates, with low reductive potentials and unstable radical intermediates but more abundant in nature and industry, have rarely been employed. Herein, we proposed a nickel‐electrocatalytic system for the regioconvergent carboxylation of unactivated olefins or halides. Various carboxylic acids were obtained by the remote hydro‐ or di‐carboxylation under mild reaction conditions with inexpensive catalysts and electrodes. It was noteworthy that readily available alkanes could also be utilized as starting substrates for the site‐selective electrocarboxylation process by the unified catalytic strategy. This method expands the scope of organic molecules coupled with CO 2 , and demonstrates the possibility of ectopic and remote C─H carboxylation. Mechanistic investigations indicated that the Ni─H species generated in the Ni‐electrocatalytic system play a key role for promoting chain walking to efficiently produce activated olefin intermediates, which subsequently undergo radical addition with CO 2 radical anion and further transform into the desired products.

Correction: Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

eLife · 2025-05-19