About

Dr. Ibrahim Z. Ades is an Affiliate Associate Professor with a Ph.D. from the University of California, Los Angeles, obtained in 1976. His research activities have been focused on two areas of cell physiology. Most of his laboratory's work has concentrated on the regulation of production and maturation of mitochondrial proteins, particularly enzymes involved in the synthesis of metalloporphyrins. More recently, his interests have shifted to studying the biochemical mechanisms that regulate angiogenesis. Dr. Ades joined the University of Maryland in 1982 and has held several significant appointments, including Acting Chair of the Department of Microbiology, Director of the Molecular and Cell Biology Program, Chair of the Department of Microbiology, and founding Chair of the Department of Cell Biology and Molecular Genetics. He teaches courses such as Cell Biology and Physiology, The Biology of Cancer, and undergraduate seminars on the Pathophysiology of the Circulatory System and on Anti-Cancer Drugs.

Research topics

• Biochemistry
• Biology
• Chemistry
• Molecular biology
• Cell biology

Selected publications

• Proceedings of the Nineteenth Annual Mid-Atlantic Chromosomal Elements Meeting

  Plasmid · 1996-05-01

  articleSenior author
  PublisherDOI

• An Acute Phase Response Factor/NF-κB Site Downstream of the junB Gene That Mediates Responsiveness to Interleukin-6 in a Murine Plasmacytoma

  Journal of Biological Chemistry · 1995-12-01 · 54 citations

  articleOpen access

  The immediate early gene, junB, is induced by interleukin-6 (IL-6) in plasmacytomas. In order to identify enhancers that mediate this effect, we cloned upstream and downstream sequences flanking the gene into a luciferase reporter gene vector containing the junB promoter and evaluated the IL-6 inducibility of these sequences by transient expression in an IL-6-dependent plasmacytoma cell line. Although a 6.5-kilobase fragment of upstream flanking sequence did not increase the IL-6 inducibility of the junB promoter, a 222-base pair fragment was identified in 2.1 kilobases of down-stream flanking sequence that both up-regulates the promoter and confers inducibility by IL-6. Point mutation of an acute phase response factor (APRF) site within this region significantly reduced up-regulation of the promoter in cells grown continuously in IL-6, as well as inducibility upon restimulation of cells with IL-6 after withdrawal from the growth factor. Point mutation of an NF-kappa B site sharing five nucleotides with the APRF site reduced up-regulation of the promoter but not inducibility by IL-6, whereas mutation of two other NF-kappa B sites in the 222-base pair fragment had no effect on expression. Western blotting of nuclear proteins purified by DNA affinity chromatography revealed inducible binding of Stat3 and constitutive binding of NF-kappa B p65 to the APRF/NF-kappa B site.

  PublisherOA PDFDOI

• Proceedings of the Eighteenth Annual Mid-Atlantic Extrachromosomal Elements and Molecular Genetics Meeting

  Plasmid · 1995-07-01

  articleSenior author
  PublisherDOI

• Visual hallucination related to severe hypophosphataemia

  The Lancet · 1991-10-01 · 10 citations

  letterSenior author
  PublisherDOI

• On the mechanism of induction of chick embryo hepatic δ-aminolaevulinate synthase by translational blockers

  Biochemical Journal · 1991-03-01 · 2 citations

  letterOpen accessSenior author

  Correspondence| March 01 1991 On the mechanism of induction of chick embryo hepatic δ-aminolaevulinate synthase by translational blockers G Ryan; G Ryan Search for other works by this author on: This Site PubMed Google Scholar I Z Ades I Z Ades Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8728 Print ISSN: 0264-6021 © 1991 The Biochemical Society, London1991 Biochem J (1991) 274 (2): 619–621. https://doi.org/10.1042/bj2740619b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation G Ryan, I Z Ades; On the mechanism of induction of chick embryo hepatic δ-aminolaevulinate synthase by translational blockers. Biochem J 1 March 1991; 274 (2): 619–621. doi: https://doi.org/10.1042/bj2740619b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1991 The Biochemical Society, London1991 Article PDF first page preview Close Modal You do not currently have access to this content.

  PublisherOA PDFDOI

• Production of δ-aminolevulinic acid: Characterization of murine liver 4,5-dioxo valeric acid : l-alanine aminotransferase

  International Journal of Biochemistry · 1991-01-01 · 4 citations

  articleSenior author
  PublisherDOI

• Induction of cytochrome P-450 RNA by porphyrogenic agents: On the nature of the coordinate induction with δ-aminolevulinate synthase in tissues of the chicken embryo

  International Journal of Biochemistry · 1990-01-01 · 7 citations

  articleSenior author
  PublisherDOI

• Mitochondrial biogenesis: Do liver mitochondria contain glycoproteins and glycosyltransferases?

  International Journal of Biochemistry · 1990-01-01 · 2 citations

  article1st authorCorresponding
  PublisherDOI

• Production of δ-aminolevulinate: Subcellular localization and purification of murine hepatic l-alanine: 4,5-dioxovaleric acid aminotransferase

  International Journal of Biochemistry · 1990-01-01 · 8 citations

  articleSenior author
  PublisherDOI

• Heme production in animal tissues: The regulation of biogenesis of δ-aminolevulinate synthase

  International Journal of Biochemistry · 1990-01-01 · 48 citations

  review1st authorCorresponding
  PublisherDOI

Recent grants

• NIH Grant R01GM031672

  NIH · $89k · 1988

Frequent coauthors

• Ronald A. Butow

  The University of Texas Southwestern Medical Center

  20 shared

• K G Harpe

  East Carolina University

  17 shared

• Theresa M. Stevens

  DuPont (United States)

  6 shared

• Paul D. Drew

  University of Arkansas for Medical Sciences

  5 shared

• Joseph Cascarano

  University of California, Los Angeles

  3 shared

• Beverly C. Rodgerson

  University of Maryland, College Park

  2 shared

• David Friedland

  University of Toronto

  2 shared

• S A Benson

  2 shared