Kayla Perry
· Assistant Professor of Forest EntomologyVerifiedOhio State University · Entomology
Active 1992–2026
About
Kayla Perry is an Assistant Professor of Forest Entomology at The Ohio State University, based in the Wooster Science Building. Her research focuses on forest entomology, contributing to the understanding of insect interactions within forest ecosystems. She is involved in academic and research activities related to entomology, with a particular emphasis on forest insects and their management.
Research topics
- Medicine
- Internal medicine
- Oncology
- Emergency medicine
- Surgery
- General surgery
- Intensive care medicine
Selected publications
Surgical Endoscopy · 2026-04-08
articleOpen accessJournal of Gastrointestinal Surgery · 2026-02-25 · 2 citations
articleOpen accessSenior authorBACKGROUND: Chronic obstructive pulmonary disease (COPD) increases surgical morbidity and mortality, but its effect on paraesophageal hernia repair (PEHR) is unknown. This study aimed to evaluate the associations between COPD and PEHR outcomes, hypothesizing an increased risk of hernia recurrence in patients with COPD. METHODS: A retrospective cohort study (2011-2022) was conducted on elective patients with PEHR, stratified into COPD and high-risk non-COPD groups (American Society of Anesthesiologists [ASA] class 3 or 4). The primary outcome was early recurrence (<6 months). Propensity score matching (1:1) was used to control for age, gender, and body mass index (BMI). The chi-squared and Mann-Whitney U tests were used to compare demographics and outcomes. Kaplan-Meier curves were used to analyze the recurrence timing, and multivariate logistic regression was used to assess COPD as an independent risk factor, adjusting for age, BMI, ASA class, and smoking status. RESULTS: Among 537 patients, 62 matched pairs were analyzed. COPD was not linked to increased respiratory complications but was associated with higher discharge to advanced care (12.9% vs 1.6%; P =.038) and earlier recurrence (160 vs 652 days; P =.01). Kaplan-Meier curves showed increased early recurrence in patients with COPD (P =.02), although recurrence rates converged later. COPD independently predicted early recurrence (odds ratio, 4.4; P <.001). CONCLUSION: COPD is an independent risk factor for early recurrence after PEHR, although it does not increase the risk of respiratory complications or overall recurrence. Patients with COPD more frequently required higher-level care and experienced earlier recurrence. Our findings may guide shared decision-making and suggest strategies to mitigate recurrence risk, such as routine mesh placement.
978: THE IMPACT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON PARAOESOPHAGEAL HERNIA REPAIR OUTCOMES
Gastroenterology · 2025-05-01
articleSenior authorSurgical Endoscopy · 2025-05-29
articleOpen access1st authorCorrespondingAfter nearly 30 years of laparoscopic anti-reflux surgery, there are so many fellows and residents that have been trained to perform these procedures.Over the course of these years, fellows and residents continue to provide ongoing training to others in anti-reflux procedures.What is clear from SAGES Masters sessions in Foregut Surgery at the annual meetings, is there are certain technical aspects of the procedure that are passed along through the ongoing Minimally Invasive Surgical training.SAGES has identified several Trailblazers in Foregut Surgery, and the following are transcripts of conversations with the founding experts in anti-reflux surgery.These were video discussions that occurred in 2019, and SAGES would like to memorialize this series as they offer truly valuable experiences.All readers will find these interviews interesting, from experts to trainees.We may be able to identify through these transcripts whose style of foregut surgery we follow.The Trailblazers were interviewed by members of the SAGES Foregut Committee during the 2019 SAGES Annual Meeting.Kyle Perry: I'm Kyle Perry, and I am an Associate Professor of Surgery at Ohio State University.I'm here today to interview Dr. John Hunter
Diabetes · 2025-06-13
articleIntroduction and Objective: With half the global population predicted to be obese by 2035, understanding the role of adiposity on obesity-associated comorbidities is critical. Adipose tissue (AT) inflammation negatively affects atherosclerosis, insulin resistance, and metabolic-associated fatty liver disease, but the mechanism behind interorgan signaling remains a mystery. Extracellular vesicles (EVs) deliver bioactive cargo to alter recipient cell function. With over 65% of circulating EV-miRNAs originating from adipocytes, we hypothesize that diet regulates adipocyte EV (AdEV) cargo trafficked to tissue-resident cells, dictating local inflammatory responses. Methods: We harvested AdEVs from the visceral AT of lean and obese C57BL/6J mice and lean and obese bariatric surgery patients who gave informed consent. Mouse AdEVs were administered in middle-aged Ldlr-/- mice, and human AdEVs were used for single-EV profiling, transcriptomics, and co-culturing. Results: Weight-matched middle-aged Ldlr-/- mice receiving obese AdEVs had increased en-face atherosclerosis (p&lt;0.0001), insulin resistance (p&lt;0.05), and hepatic steatosis (p&lt;0.05), while lean AdEVs had no effect. The immune milieu in the aorta, liver, and spleen internalized AdEVs (p&lt;0.05). Macrophages endocytosed human AdEVs into endosomal/lysosomal compartments with obese AdEVs colocalizing more with the latter (p&lt;0.0001) and induced heightened pro-inflammatory responses, including IL12B(&gt;250-fold; p&lt;0.001) and IL1B(60-fold; p&lt;0.01). AdEVs from lean and obese patients contained differential miRNA cargo (p&lt;0.05) mirrored in AdEVs from lean and obese mice. Classical EV and adipocyte-specific biomarkers on the single-AdEV surface revealed more AdEVs in obese subjects’ plasma (p&lt;0.05). Conclusion: In obesity, AdEVs accelerate atherosclerosis, insulin resistance, and hepatic steatosis through uptake, internalization, cargo delivery, and increased production of circulating AdEVs, suggesting AdEVs are a major mechanism. Disclosure X.Y. Rima: None. D. Shantaram: None. J.Z. Liu: None. V.P. Wright: None. A. Amari: None. J. Doon-Ralls: None. T.K. Nguyen: None. J. Rottinghaus: None. J.M. Fernandes: None. D.S. Patel: None. A.D. Jalilvand: None. B.J. Needleman: Speaker's Bureau; Intuitive Surgical, Medtronic. S. Noria: None. S. Brethauer: None. K.A. Perry: None. E. Reategui: None. W. Hsueh: None. Funding National Institutes of Health (5T32HL149637); Burroughs Wellcome Fund (1285320)
2025-01-01
book-chapterSenior authorGastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology
Journal of the National Comprehensive Cancer Network · 2025-05-01 · 123 citations
articleGastric cancer is the fifth leading cause of cancer-related deaths worldwide. Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. Gastric cancer generally carries a poor prognosis because it is often diagnosed at an advanced stage. Systemic therapy can provide palliation, improve survival, and enhance the quality of life in patients with locally advanced or metastatic disease. The implementation of biomarker testing has had a significant impact on clinical practice and patient care. Targeted therapies have demonstrated encouraging results in clinical trials for the treatment of patients with locally advanced or metastatic disease. This selection from the NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer highlights recommendations for biomarker testing and discusses updates for the treatment of advanced disease, including peritoneal carcinoma as only disease and unresectable locally advanced, recurrent, or metastatic disease.
Nature Communications · 2024-06-27 · 52 citations
articleOpen accessNeutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more neutrophils than in those without obesity and is associated with a distinct bacterial community. Exploring the mechanism, we gavaged microbiome-depleted mice with stool from patients with and without obesity during high-fat or normal diet administration. Only mice receiving high-fat diet and stool from subjects with obesity show enrichment of VAT neutrophils, suggesting donor microbiome and recipient diet determine VAT neutrophilia. A rise in pro-inflammatory CD4+ Th1 cells and a drop in immunoregulatory T cells in VAT only follows if there is a transient spike in neutrophils. Human VAT neutrophils exhibit a distinct gene expression pattern that is found in different human tissues, including tumors. VAT neutrophils and bacteria may be a novel therapeutic target for treating inflammatory-driven complications of obesity, including insulin resistance and colon cancer.
Annals of Oncology · 2024-09-01 · 17 citations
articleRegular and Young Investigator Award Abstracts · 2024-11-01
articleOpen access<h3>Background</h3> Well-differentiated liposarcoma [WDLPS], a low-grade disease, can evolve into dedifferentiated liposarcoma [DDLPS,] a high-grade disease associated with increased local recurrence and distant metastasis. Currently the most effective treatment for WDLPS and DDLPS is surgical resection however, DDLPS patients have high rates of recurrence and derive little benefit from current systemic treatments. The reasons underlying lack of success with immunotherapeutics for DDLPS are undetermined, in part due to our minimal understanding of the tumor immune microenvironment [TIME] of DDLPS. Here we conducted characterization of the TIME of DDLPS using primary patient tumors. <h3>Methods</h3> Characterization was conducted via multiplexed-IHC [OPAL] followed by Vectra Polaris scanning to visually determine the TIME architecture of DDLPS [n=9]. OPAL scans were then analyzed with Inform tissue analysis software and the phenoptrReports R studio package to yield immune cell detection data, cell segmentation data, and nearest neighbor spatial data. Quantification of TILs was performed via OPAL analyses. TIL high [DDLPS<sub>high</sub>; n=5] and low [DDLPS<sub>low</sub>; n=4] tumors were defined by greater or less than 10% CD3+/total cells, respectively. Single-nuclei RNA sequencing [snRNA-seq] was performed on a DDLPS<sub>high</sub> tumor. Bulk RNA-seq was performed on DDLPS [n=8] and normal fat [NF; n =8] samples. <h3>Results</h3> OPAL analysis revealed distinct differences in the TIME architecture of DDLPS. Two distinct DDLPS TIMEs were identified with either low TILs [DDLPS<sub>low</sub>, n=4] or high TILs [DDLPS<sub>high</sub>, n=5]. DDLPS<sub>high</sub> tumors were found to have more exhausted T Cells [CD3+/CD8a+/PD1+] in their TIME versus DDLPS<sub>low</sub> tumors (figure 1). Further probative analysis was performed on a DDLPS<sub>high</sub> tumor via snRNA-seq which yielded three distinct resident memory T Cell [T<sub>RM</sub>] clusters which all showed high expression of the exhaustion marker TOX; bulk RNA-seq also showed higher TOX expression levels for DDLPS compared to NF (figure 2). These results suggest that terminal T cell exhaustion might contribute to the lack of immunotherapy response in DDLPS, even in patients with high TILs in their TIME. <h3>Conclusions</h3> The TIME of DDLPS is heterogenous across patient samples with both high and low TIL profiles. Notably DDLPS with high TILs in the TIME were found to have high TOX expression exhausted T cells. These findings highlight the potential cause of single agent immune checkpoint blockade [ICB] efficacy failure in patients with DDLPS in clinical trials. These data suggest the need for novel therapeutic strategies via exhaustion reversal. <h3>Acknowledgements</h3> Research fundings from NIH-NCI R03CA280126; CTSA: UL1TR002240; Rogel Cancer Center/University of Michigan Cancer Discovery Grant. <h3>Ethics Approval</h3> This study was approved by the University of Michigan’s institution’s IRB Ethics Board; approval #HUM00196054.
Frequent coauthors
- 32 shared
W. Scott Melvin
Albert Einstein College of Medicine
- 22 shared
John G. Hunter
LightMachinery (Canada)
- 20 shared
Jeffrey W. Hazey
Memorial Health System
- 20 shared
Anahita Jalilvand
- 20 shared
Robert E. Merritt
The Ohio State University Wexner Medical Center
- 20 shared
Reginald Bell
- 20 shared
Shanu N. Kothari
Prisma Health
- 19 shared
John C. Lipham
University of Southern California
Labs
Education
- 2009
Research and Clinical Fellow, Minimally Invasive Surgery
Oregon Health & Science University
- 2007
Resident, Cook County Hospital Integrated Surgical Residency Program
Rush University Medical Center
- 2002
MD
Temple University School of Medicine
- 1998
BA, Pyschology
University of Michigan
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