
Konrad Lebioda
· Assistant ProfessorRutgers University · Radiology
Active 2011–2023
About
Professor Konrad Lebioda is affiliated with Rutgers New Jersey Medical School, serving in the Department of Radiology. His professional expertise includes neuroradiology, head and neck radiology, and advanced neuroimaging. He holds an MD degree obtained in 1976 from Kaohsiung Medical College in Taiwan. He is licensed to practice medicine in New Jersey and is certified by the American Board of Radiology in Diagnostic Radiology. His language skills include Chinese and Taiwanese. His clinical practice is associated with University Hospital in Newark and VA Medical Center in East Orange. The information provided is subject to change and should be verified with the relevant insurance providers.
Research topics
- Internal medicine
- Surgery
- Medicine
- Nuclear medicine
- Cardiology
Selected publications
Stroke · 2023-02-01
articleIntroduction: Transradial approach (TRA) is emerging as an alternative to the traditional transfemoral approach (TFA) for mechanical thrombectomy (MT). We aim to identify various aortic arch and carotid artery anatomy parameters associated with a conversion from a TRA to a TFA for MT at a comprehensive stroke center (CSS). Methods: We performed a retrospective chart review of patients who underwent MT at a CSS from 1/2019 to 12/2021. We compared various aortic arch and carotid artery anatomy parameters between patients who had a successful MT via the TRA versus those who required a conversion from a TRA to a TFA for MT. A blinded board-certified neuroradiologist used the pre-MT CT Angiogram to document different aortic arch and carotid artery anatomy variables. A binary logistic regression analysis was performed, controlling for age, gender, presenting mean arterial pressure (MAP), presenting serum glucose, Hb A1C, LDL, left hemispheric location, and the location of occlusion [proximal (ICA or M1 segment of the middle cerebral artery) versus distal (M2 segment of the middle cerebral artery)]. Results: 68 patients met our inclusion criteria. The mean age was 66.08±15.09 years. 12 (17.65%) patients had to be converted from a TRA to a TFA for MT. In our cohort, the absence of a double subclavian-innominate curve (55.36% vs. 27.28%; OR, 12.5; 95 % CI, 1.76-88.52; P 0.011) and a higher diameter of the aortic arch at the apex (28.75±2.38mm vs.27.5±2.88mm; OR, 1.44; 95 % CI, 1.01-2.06; P 0.042) were significantly associated with a conversion from TRA to TFA. The other aortic arch and carotid artery anatomy parameters were not significantly associated with the conversion from a TRA to a TFA, as shown in the Table. Conclusion: Among aortic arch and carotid artery anatomy parameters, the absence of a double subclavian-innominate curve and a higher diameter of the aortic arch at the apex were significantly associated with a conversion from a TRA to a TFA for MT in our cohort.
Stroke · 2023-02-01
articleIntroduction: The American Heart Association recommends a Door-to-Recanalization/Reperfusion (DTRp) time of ≤120 minutes. We aim to identify aortic arch and carotid artery anatomy parameters associated with a delayed DTRp at a comprehensive stroke center (CSS). Methods: We performed a retrospective chart review of patients who underwent mechanical thrombectomy (MT) for an anterior circulation large vessel occlusion (LVO) at a CSS from 1/2015 to 12/2021. We compared various aortic arch and carotid artery anatomy parameters between patients who achieved DTRp in ≤120 minutes vs.>120 minutes. A blinded board-certified neuroradiologist used the pre-MT CT Angiogram to document different aortic arch and carotid artery anatomy variables. A binary logistic regression analysis was performed, controlling for age, gender, presenting mean arterial pressure (MAP), presenting serum glucose, Hb A1C, LDL, intravenous alteplase, left hemispheric location, location of occlusion [proximal (ICA or M1 segment of the middle cerebral artery) versus distal (M2 segment of the middle cerebral artery)], ASPECTS≥6, general anesthesia, transradial approach, number of passes. Results: 256 patients met our inclusion criteria. The mean age was 65.18±14.89 years. In our cohort, the presence of a bovine arch was significantly associated with a DTRp of >120 minutes (39.19% vs. 20.59%; OR, 0.37; 95 % CI, 0.15-0.94; P 0.035). Whereas, the other aortic arch and carotid artery anatomy parameters were not significantly associated with DTRp of >120 minutes, as shown in the Table. Conclusion: Among aortic arch and carotid artery anatomy parameters, the presence of a bovine arch was associated with significantly delayed DTRp of >120 minutes in our cohort.
Journal of Clinical Neuroscience · 2023-11-07 · 1 citations
articleCorrespondingInterventional Neuroradiology · 2022-11-17 · 1 citations
articleIntroduction: Cerebral collateral circulation refers to the anastomoses that reroute the blood flow to the ischemic penumbra in the event of a large vessel occlusion (LVO). We aim to determine the utility of pre-mechanical-thrombectomy (MT) collateral scores in the early (<6 h from onset) versus extended (6–24 h from onset) window for MT with respect to a 3-month functional outcome, 3-month mortality, and early neurological improvement. Methods: We performed a retrospective chart review of patients who underwent MT for an anterior circulation LVO at a comprehensive stroke center from 7/2014 to 12/2020. A board-certified neuroradiologist, who was blinded to the clinical outcomes, used the collateral grading scales of Miteff (ordinal), Maas (ordinal), and modified-Tan (dichotomous) to designate collateral scores on the pre-MT CT Angiogram. The patients were divided into early (<6 h from onset) versus extended (6–24 h from onset) window groups depending on their timing of presentation to the emergency department. A regression analysis was performed, controlling for the baseline parameters, with the pre-MT collateral grading scores as predictors. The outcome measures were a good functional outcome (3-month mRS 0-2), mortality, and early neurological improvement. Results: A total of 220 patients met the inclusion criteria. In the overall cohort, the pre-MT scale of Maas was associated with a good functional outcome (OR, 0.58; 95% CI, 0.34–0.99; P 0.047) and mortality (OR, 0.55; 95% CI, 0.31–0.97; P 0.036). For the 162 patients who presented in the early window for MT, all of three pre-MT scales of Maas (OR, 0.39; 95% CI, 0.2–0.77; P 0.006), Miteff (OR, 0.43; 95% CI, 0.19–0.97; P 0.042) and modified-Tan (OR, 5.62; 95% CI, 1.16–27.37; P 0.033) were associated with a good functional outcome, whereas the Maas (OR, 0.48; 95% CI, 0.26–0.9; P 0.021) and the Miteff scale (OR, 0.4; 95% CI, 0.22–0.74; P 0.003) were associated with mortality. For the 58 patients who presented in the extended window for MT, none of the collateral grades were associated with functional outcome, mortality, or early neurological improvement. Conclusions: Our study demonstrates that while several collateral grades are helpful to predict outcomes in patients presenting in the early window, none of the pre-MT collateral scores were associated with outcomes in patients who presented in the extended window for MT. Thus, the current strategy of using perfusion imaging for the selection of patients for MT in the extended window should continue.
Journal of Clinical Neuroscience · 2022 · 9 citations
- Medicine
- Internal medicine
- Surgery
Stroke · 2022-02-01
articleIntroduction: Higher blood pressure (BP) most post mechanical thrombectomy (MT) can influence perfusion in the ischemic brain tissue depending on collateral status. We aim to determine the association of 24 hour post MT BP parameters with the functional outcome depending on the pre MT collateral status. Methods: We performed a retrospective chart review of patients who underwent MT at a comprehensive stroke center from 7/2014 to 12/2020. The patients were divided into two groups (good versus bad) depending on collateral status. A board certified neuroradiologist, who was blinded to the clinical outcomes, used collateral grading scales of Mass ≥3 and modified-Tan>50% to designate good collaterals on the pre MT CT Angiogram. A binary logistic regression analysis was performed, controlling for age, sex, NIHSS, ASPECTS≥6, TICI score≥2b, time to thrombectomy, LDL, Hemoglobin A1C, intravenous alteplase, with the 24 hour post MT BP parameters as the predictors. The outcomes were good functional outcome (90 day mRS≤2) and mortality. Results: 220 patients met the inclusion criteria. Lower 24 hour BP parameters of standard deviation (SD) SBP (OR,1.16; 95% CI,1.01-1.33; P 0.047) and maximum DBP (OR,1.05; 95% CI,1.01-1.09; P 0.036) were associated with good functional outcome, while higher values of SD SBP (OR,1.15; 95% CI,1.01-1.31; P 0.045), coefficient variation (CV) SBP (OR,1.19; 95% CI,1.01-1.41; P 0.043), SBP range (OR,1.04; 95% CI,1.01-1.07; P 0.046), maximum DBP (OR,0.95; 95% CI,0.91-0.99; P 0.016), pulse pressure (OR,1.09; 95% CI,1.02-1.16; P 0.022) and SBP≥140 (OR,5.85; 95% CI,1.11-30.85; P 0.038) were associated with mortality in patients with good collaterals according to Mass grading. Higher values of BP parameters of SD SBP (OR,1.13; 95% CI,1.04-1.24; P 0.007), CV SBP (OR,1.18; 95% CI,1.05-1.32; P 0.006), SBP range (OR,1.04; 95% CI,1.01-1.06; P 0.008) and maximum DBP (OR,0.97; 95% CI,0.94-1; P 0.02) were associated with mortality in patients with good collaterals according to modified-Tan grading. There was no such association in patients with bad collaterals. Conclusion: Various higher 24 hour BP parameters post MT are associated with a bad functional outcome or mortality in patients with good collaterals, unlike in patients with bad collaterals.
Journal of the Neurological Sciences · 2022 · 4 citations
- Medicine
- Internal medicine
- Cardiology
Stroke · 2022-02-01
articleIntroduction: We aim to determine the association of pre-mechanical-thrombectomy (MT) collateral scores in the short (<6 hours from onset) versus extended (6-24 hours from onset) window for MT with a good functional outcome. Methods: We performed a retrospective chart review of patients who underwent MT for anterior circulation large vessel occlusion at a comprehensive stroke center from 7/2014 to 12/2020. A board-certified neuroradiologist, who was blinded to the clinical outcomes, used collateral grading scales of Miteff (ordinal), Mass (ordinal), and modified-Tan (dichotomous) to designate collateral scores on the pre-MT CT Angiogram. The patients were divided into short (<6 hours from onset) versus extended (6-24 hours from onset) groups depending on their timing of presentation to the emergency department. A binary logistic regression analysis was performed, controlling for age, sex, NIHSS, ASPECTS≥6, TICI score≥2b, recanalization time, mean arterial pressure, blood glucose, location of the occlusion, atrial fibrillation, LDL, hemoglobin-A1C, and administration of intravenous-alteplase, with the pre-MT collateral grading scores as predictors. The primary outcome was a good functional outcome (3-month mRS≤2). Results: 220 patients met the inclusion criteria.162 patients presented in the short window for MT. The pre-MT scales of Mass (OR, 0.35; 95%CI, 0.16-0.78; P 0.01) and modified-Tan (OR, 0.35; 95%CI, 0.16-0.78; P 0.01) were associated with a good functional outcome, unlike the Miteff scale (OR, 0.46; 95% CI, 0.18-1.18; P 0.103). 58 patients met our inclusion criteria for patients who presented in the extended window for MT. The pre-MT scales of Mass (OR, 0.75; 95% CI, 0.23-2.48; P 0.63), Miteff scale (OR, 0.78; 95%CI, 0.17-3.64; P 0.746) and modified-Tan (OR, 1.14; 95%CI, 0.1-12.98; P 0.918) were not associated with a good functional outcome. Conclusions: Our study demonstrates that good collateral grades on Mass and modified-Tan scales are associated with a good functional outcome for patients who present to the ED in the short window for MT. We did not find an association of any pre-MT collateral scores with a good functional outcome for patients presenting in the extended window for MT.
Stroke Vascular and Interventional Neurology · 2021-11-01
articleOpen accessThis meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
Stroke Vascular and Interventional Neurology · 2021-11-01
articleOpen accessThis meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
Frequent coauthors
- 23 shared
Toluwalase Tofade
Harvard University
- 19 shared
Taha Nisar
Rutgers New Jersey Medical School
- 19 shared
Priyank Khandelwal
Rutgers, The State University of New Jersey
- 13 shared
Osama Abu‐hadid
Mount Sinai Beth Israel
- 6 shared
Priyank Khandelwal
Neurological Surgery
- 5 shared
Shaul Shaulov
Rutgers, The State University of New Jersey
- 5 shared
Sara Shapouran
- 2 shared
Muhammad Zeeshan Memon
The University of Texas Medical Branch at Galveston
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