About

Laura M. Ades, MD, is a clinical assistant professor in the Department of Neurology at NYU Grossman School of Medicine. She specializes in vascular neurology and treats adult patients. Dr. Ades completed her undergraduate and medical training in the Midwest, followed by neurology residency in New Orleans, Louisiana. She further specialized with a stroke fellowship as the StrokeNet fellow at the University of Cincinnati. Since joining NYU Langone Hospital—Brooklyn in 2021, she has been actively involved in working with a dedicated stroke team to guide patients through stroke recovery and determine the causes of strokes. She finds particular satisfaction in seeing patients improve and in helping them prevent future strokes. Additionally, Dr. Ades contributes to the education of neurology residents and medical students, sharing her expertise and experience in the field.

Research topics

• Medicine
• Environmental health
• Demography
• Internal medicine
• Pediatrics

Selected publications

• Abstract DP161: Improved Time to Treatment in Intracerebral Hemorrhage after GWTG Education Initiative

  Stroke · 2026-01-29

  article

  Introduction: There has been a growing effort recently to improve intracerebral hemorrhage (ICH) care. We evaluated the impact of a GWTG ICH quality improvement initiative launched in February 2023 at three campuses of an academic comprehensive stroke center. Methods: We compared treatment times in ICH patients requiring hypertension management (admission SBP ≥150 mmHg) and/or anticoagulation (AC) reversal who were admitted from 1/1/2017-12/31/2022 (pre-initiative) to a similar group admitted after the ICH quality initiative was launched (4/1/2023-4/30/2025) (post-initiative) at three campuses of an academic comprehensive stroke center in New York City. Patients transferred from another facility or with in-hospital ICH were excluded. The initiative consisted of several departmental briefings and announcements on the importance of prompt imaging and administration of treatments, with blood pressure (BP) lowering medications being encouraged to be given in the CT scanner rather than in the ED, and AC reversal agents being more readily available in the ED. Further, designated stroke coordinators started sending out monthly reports of ICH metrics to hospital departments. The primary outcome was the time from CT read to administration of either BP medication or AC reversal agent. Results: Of 530 ICH patients, (N=312 pre-initiative, N=213 post-initiative), 508 received BP medication and 87 received an AC reversal agent. The time from CT read to treatment (either BP medication or AC reversal agent) significantly declined from a median of 24 minutes pre- to 16 minutes post-initiative (P=0.005). This effect was primarily driven by reductions in CT to BP medication administration (median 24 minutes pre- and 13 minutes post-initiative, P=0.002), whereas time to AC reversal agent actually increased (median 44 minutes pre- to 78 minutes post-initiative, P=0.018). There were no differences in other time metrics including last known normal (LKN) to door, door to stroke team, door to CT, door to BP medication, or door to AC reversal, though door to ED provider was significantly lower post-initiative (median 4 minutes pre- to <1 minute post-initiative, P<0.001). Conclusions: A brief education initiative aimed at improving treatment times successfully reduced time to BP medication administration in ICH, though no improvements were seen in time to anticoagulant reversal. Additional sustained education and quality improvement projects are required to further streamline workflow.

  PublisherDOI

• 1361: IMPROVING TIME TO TREATMENT METRICS IN INTRACEREBRAL HEMORRHAGE (ICH) PATIENTS: A CODE ICH REPORT

  Critical Care Medicine · 2025-01-01

  article
  PublisherDOI

• Code ICH: Identifying Factors Delaying Timely Diagnosis and Treatment of Intracerebral Hemorrhage (ICH) (P5-13.006)

  Neurology · 2025-04-07

  article

  To identify patient-related, provider-related, and clinical factors that delay the timely diagnosis and treatment of ICH.

  PublisherDOI

• Developing Transformative Technologies to Enhance Equitable Acute Stroke Care in Patients with Limited English Proficiency (P12-5.025)

  Neurology · 2025-04-07

  article

  NA

  PublisherDOI

• Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study

  Journal of the American Heart Association · 2024-05-03

  articleOpen access

  Background Hypertension is a stroke risk factor with known disparities in prevalence and management between Black and White patients. We sought to identify if racial differences in presenting blood pressure (BP) during acute ischemic stroke exist. Methods and Results Adults with acute ischemic stroke presenting to an emergency department within 24 hours of last known normal during study epochs 2005, 2010, and 2015 within the Greater Cincinnati/Northern Kentucky Stroke Study were included. Demographics, histories, arrival BP, National Institutes of Health Stroke Scale score, and time from last known normal were collected. Multivariable linear regression was used to determine differences in mean BP between Black and White patients, adjusting for age, sex, National Institutes of Health Stroke Scale score, history of hypertension, hyperlipidemia, smoking, stroke, body mass index, and study epoch. Of 4048 patients, 853 Black and 3195 White patients were included. In adjusted analysis, Black patients had higher presenting systolic BP (161 mm Hg [95% CI, 159–164] versus 158 mm Hg [95% CI, 157–159], P <0.01), diastolic BP (86 mm Hg [95% CI, 85–88] versus 83 mm Hg [95% CI, 82–84], P <0.01), and mean arterial pressure (111 mm Hg [95% CI, 110–113] versus 108 mm Hg [95% CI, 107–109], P <0.01) compared with White patients. In adjusted subanalysis of patients <4.5 hours from last known normal, diastolic BP (88 mm Hg [95% CI, 86–90] versus 83 mm Hg [95% CI, 82–84], P <0.01) and mean arterial pressure (112 mm Hg [95% CI, 110–114] versus 108 mm Hg [95% CI, 107–109], P <0.01) were also higher in Black patients. Conclusions This population‐based study suggests differences in presenting BP between Black and White patients during acute ischemic stroke. Further study is needed to determine whether these differences influence clinical decision‐making, outcome, or clinical trial eligibility.

  PublisherOA PDFDOI

• First‐Line Treatment of Symptomatic Subocclusive Large‐Vessel Stroke: Results of a Nationwide StrokeNet Survey

  Stroke Vascular and Interventional Neurology · 2024-05-16

  articleOpen access

  BACKGROUND: Limited evidence is available for the treatment of acute symptomatic sub-occlusive lesions in ischemic stroke. We sought to identify current treatment patterns of stroke teams at academic health centers. METHODS: We conducted an email survey of the National Institutes of Health (NIH) StrokeNet regional coordinating centers (RCCs). Each RCC principal investigator (PI) was asked to nominate a local stroke interventionalist, or neurologist if the RCC PI was an interventionalist, most aligned with the typical practice pattern of the RCC's lead hospital, to receive a survey. The survey consisted of a clinical vignette and displayed a sub-occlusive lesion in the left middle cerebral artery on CT angiogram followed by subsequent scenarios, revising only one historical, clinical, or radiographic variable at a time. Participants were asked to select initial management for each scenario. Results were reviewed and analyzed by stroke-trained physicians. RESULTS: Responses were received from 42 (77.8%) of 54 surveyed individuals, representing 25 (92.6%) of 27 RCCs nationwide, including 25 (59.5%) interventionalists. The majority (76.2%) of respondents treated the patient in the primary clinical vignette with mechanical thrombectomy (MT). Among all six clinical scenarios, respondents chose MT with or without medical management as first-line treatment for four (67%) vignettes. Exceptions were low NIH Stroke Scale and known ipsilateral stenosis, where respondents chose medical management as first-line treatment. CONCLUSIONS: Despite limited evidence to support MT versus other treatment strategies, the majority of StrokeNet RCCs respondents would use MT with or without medical therapy to treat AIS due to intracranial sub-occlusive lesions.

  PublisherDOI

• Abstract 237: Thrombectomy is the Leading Treatment Modality for Symptomatic Sub‐Occlusive Lesions: a Nationwide StrokeNet Survey

  Stroke Vascular and Interventional Neurology · 2023-11-01

  articleOpen access

  Introduction Approximately 3% of all acute ischemic stroke are caused by sub‐occlusive thrombi in the proximal intracranial vasculature. There is a paucity of evidence regarding optimal treatment of this stroke etiology, with most evidence derived from retrospective case series preceding the advent of mechanical thrombectomy. We sought to survey the National Institute of Health StrokeNet to determine real‐world treatment patterns in experienced stroke centers. We hypothesized that most providers would choose mechanical thrombectomy (MT) over medical management (MM). Methods We conducted an email survey of all StrokeNet regional coordinating centers (RCCs). Each RCC principal investigator (PI) was asked to provide a name of a local stroke endovascular specialist most aligned with their region’s typical practice pattern. A subsequent survey was sent to each if the StrokeNet RCC PIs and their nominated interventionalists. Questions were based on a clinical vignette accompanied by CT angiogram displaying a sub‐occlusive lesion in the left middle cerebral artery (MCA) (Figure 1a). Subsequent questions kept the same basic vignette, changing only one historical, clinical, or radiographic variable at a time. Participants were asked to describe initial management for each scenario. If more than one initial treatment was selected, or if no treatment option was selected, applicants were asked to please explain. Results were gathered from each participant using Google Forms. Results Among 27 StrokeNet RCCs, 25 (93%) provided at least one response; responses were received from 43 of 54 (80%) physicians surveyed, including 26 stroke interventionalists. A total of 4 sites selected an alternate responder of the appropriate specialty if their PI or chosen representative was unable to respond. The majority (71.4%) of respondents treated patients with acute sub‐occlusive thrombus with MT (Figure 1b). MT alone, or MT with additional MM, comprised the majority of responses to clinical vignette variation questions[Moderate core (ASPECTS 6): 71.4% MT, 76.2% MT with MM; Last Known Normal 12‐hours prior with Favorable Advanced Imaging: 73.8% MT, 83% MT with MM; Last Known Normal 12‐hours prior without Advanced Imaging: 54.8% MT, 64.3% MT with MM; Severe hypertension (210/110mmHg): 50% MT, 69% MT with MM; Poor Collaterals: 71.4% MT, 78.6% MT with MM]. Only two scenarios, low baseline National Institutes of Health Stroke Score (NIHSS) and history of ipsilateral stenosis, led respondents to favor non‐thrombectomy approaches (Low NIHSS (3): 9.5% MT; History of Ipsilateral Stenosis: 30.9% MT, 47.6 MT with MM) (Figure1c‐d). Conclusion Despite limited evidence to support MT versus other treatment strategies, the majority of StrokeNet Regional Coordinating Center sites would use MT to treat acute strokes due to intracranial sub‐occlusive thrombi.

  PublisherDOI

• Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015

  Neurology · 2023 · 6 citations

  • Medicine
  • Internal medicine
  • Pediatrics

  <h3>Background and Objectives</h3> There is a rising incidence of infective endocarditis–related stroke (IERS) in the United States attributed to the opioid epidemic. A contemporary epidemiologic description is necessary to understand the impact of the opioid epidemic on clinical characteristics of IERS. We describe and analyze trends in the demographics, risk factors, and clinical features of IERS. <h3>Methods</h3> This is a retrospective cohort study within a biracial population of 1.3 million in the Greater Cincinnati/Northern Kentucky region. All hospitalized patients with hemorrhagic or ischemic stroke were identified and physician verified from the 2005, 2010, and 2015 calendar years using ICD-9 and ICD-10 codes. IERS was defined as an acute stroke attributed to infective endocarditis meeting modified Duke Criteria for possible or definite endocarditis. Unadjusted comparison of demographics, risk factors, outcome, and clinical characteristics was performed between each study period for IERS and non-IERS. An adjusted model to compare trends used the Cochran-Armitage test for categorical variables and a general linear model or Kruskal-Wallis test for numerical variables. Examination for interaction of endocarditis status in trends was performed using a general linear or logistic model. <h3>Results</h3> A total of 54 patients with IERS and 8,204 without IERS were identified during the study periods. Between 2005 and 2015, there was a decline in rates of hypertension (91.7% vs 36.0%; <i>p</i> = 0.0005) and increased intravenous drug users (8.3% vs 44.0%; <i>p</i> = 0.02) in the IERS cohort. The remainder of the stroke population demonstrated a significant rise in hypertension, diabetes, atrial fibrillation, and perioperative stroke. Infective endocarditis status significantly interacted with the trend in hypertension prevalence (<i>p</i> = 0.001). <h3>Discussion</h3> From 2005 to 2015, IERS was increasingly associated with intravenous drug use and fewer risk factors, specifically hypertension. These trends likely reflect the demographics of the opioid epidemic, which has affected younger patients with fewer comorbidities.

  PublisherOA PDFDOI

• Abstract WP177: Trends In The Clinical Phenotype Of Infective Endocarditis Related Stroke From 2005-2015: A Population-Based Study Of The Greater Cincinnati/ Northern Kentucky Region

  Stroke · 2022-02-01

  article

  Background: Prior studies have demonstrated a rising incidence of infective endocarditis related stroke (IERS) in the US due to the opioid epidemic. The Greater Cincinnati/Northern Kentucky (GCNK) region has one of the highest opioid abuse rates in the nation. A modern epidemiologic description is necessary to understand the impact of the opioid epidemic on the clinical phenotype of IERS. Methods: Using the GCNK Stroke Study, all patients hospitalized with IERS in 2005, 2010, and 2015 were abstracted and physician reviewed. IERS was defined as an acute stroke clinically attributed to infective endocarditis in patients meeting modified Duke Criteria for possible or definite endocarditis. Comparison between years were by chi-square or Fisher’s exact test for categorical variables; ANOVA or Kruskal-Wallis test for numerical variables. Cochran-Armitage test was used to examine trend. Secondary analysis compared characteristics between intravenous drug users (IVDU) and non-IVDU. Results: A total of 54 patients with IERS were identified in 2005, 2010, and 2015. Over the period, there was a significant decline in hypertension (91.7% in 2005, 36.0% in 2015; p=0.0005) and increase in IVDU (8.3% in 2005, 44.0% in 2015; p=0.02). They trended towards increased white race, younger age, and fewer vascular risk factors. Compared to non-IVDU, IVDU were significantly younger (41.1±14.1vs 63.1±14.3 years; p&lt;0.001), less often female (12.5% vs 47.4%; p=0.02), had higher rates of sepsis (50% vs 18.4%; p=0.04), less atrial fibrillation (0% vs 31.6%; p=0.01), and less renal disease (0% vs 23.7%; p=0.045). The incidence of IERS per 100,000 increased from 1.31 (CI: 0.56-2.06) in 2005, to 1.66 (CI: 0.87-2.45) in 2010, and to 2.41(CI:1.46-3.36) in 2015. Conclusion: From 2005 to 2015, IERS was increasingly associated with IVDU and an absence of hypertension. These trends likely reflect the demographics of the opioid epidemic, which has affected younger patients with less comorbidities.

  PublisherDOI

• Abstract TP225: Socioeconomic Status And Etiologies Of Ischemic Stroke In Peru

  Stroke · 2022-02-01

  article

  Background: Studies have reported an association between lower socioeconomic status (SES) and an elevated risk of ischemic stroke. It is unclear whether low SES is correlated with a specific etiology of ischemic stroke. Few studies have investigated the relationship in LMIC nations with wide disparities in SES. We analyzed data from a hospital-based stroke registry in Lima, Peru to determine the association between level of education as an indicator of SES and ischemic stroke etiology. Methods: All patients hospitalized with ischemic stroke at the National Institute of Neurologic Sciences from 2015-2018 were prospectively collected in a registry including demographics, risk factors, highest attained level of education, and diagnosed etiology of stroke by TOAST criteria. Association between ordinal level of education and stroke etiology was assessed after adjusting for differences in demographics and comorbidities by a multinomial multivariate logistic regression model. Results: A total of 461 cases of ischemic stroke were ascertained with 38.4% female and a mean age of 66.2 (SD 13.0). Stroke etiology was composed of 7.5% atherosclerotic, 29.7% cardioembolic, 14.2% small vessel disease, 24.7% cryptogenic, and 24.0% with incomplete evaluation. Higher education level strata had more men, younger mean age, and lower rates of hypertension. After multivariate adjustment, lower level of education was associated with an increased odds of large artery atherosclerosis compared to all non-cardioembolic etiologies (OR=2.27; 95% CI, 1.12-4.55). There was no significant association with level of education and odds of cardioembolic stroke after multivariate adjustment. Conclusion: Lower SES is associated with an increased odds of atherosclerotic etiology in patients with non-cardioembolic ischemic stroke. The associated between SES and stroke may be attributed to a higher burden of atherosclerotic disease in lower SES.

  PublisherDOI

Frequent coauthors

• Yasmin Aziz

  Johns Hopkins Medicine

  175 shared

• Pooja Khatri

  Augusta University

  174 shared

• Mohamed Ridha

  The Ohio State University

  174 shared

• Stacie L Demel

  McMaster University

  173 shared

• Daniel Woo

  University of Cincinnati

  173 shared

• Kyle B Walsh

  Walsh University

  173 shared

• Felipe De Los Rios La Rosa

  Baptist Health South Florida

  173 shared

• Mary Haverbusch

  173 shared