Reading Empson: The Structure of Complex Words

ELH · 2021-01-01 · 1 citations

The difficulties of reading William Empson's prose are almost universally acknowledged, but the explanations, defenses, or excuses for his wilfulness vary greatly. This essay argues that Empson's title words "types" and especially "structure" have often misled readers. By scrutinizing key terms in his vocabulary (including structure, bundle, puzzle, and process), the essay concludes that complexity is his goal, rather than, say, pastoral ease. The aim of his writing, throughout his career, is an understanding of the pressures of life in a multi-voiced, democratic society.

Vale atque Ave

Modern Language Quarterly · 2021-06-01 · 1 citations

Editorial| June 01 2021 Vale atque Ave Marshall Brown Marshall Brown Search for other works by this author on: This Site Google Modern Language Quarterly (2021) 82 (2): 141–148. https://doi.org/10.1215/00267929-9010522 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Marshall Brown; Vale atque Ave. Modern Language Quarterly 1 June 2021; 82 (2): 141–148. doi: https://doi.org/10.1215/00267929-9010522 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter Books & JournalsAll JournalsModern Language Quarterly Search Advanced Search Issue Section: From the Editor You do not currently have access to this content.

17-Gene Genomic Prostate Score Test Results in the Canary Prostate Active Surveillance Study (PASS) Cohort

Journal of Clinical Oncology · 2020-03-04 · 75 citations

PURPOSE The 17-gene Onco type DX Genomic Prostate Score (GPS) test predicts adverse pathology (AP) in patients with low-risk prostate cancer treated with immediate surgery. We evaluated the GPS test as a predictor of outcomes in a multicenter active surveillance cohort. MATERIALS AND METHODS Diagnostic biopsy tissue was obtained from men enrolled at 8 sites in the Canary Prostate Active Surveillance Study. The primary endpoint was AP (Gleason Grade Group [GG] ≥ 3, ≥ pT3a) in men who underwent radical prostatectomy (RP) after initial surveillance. Multivariable regression models for interval-censored data were used to evaluate the association between AP and GPS. Inverse probability of censoring weighting was applied to adjust for informative censoring. Predictiveness curves were used to evaluate how models stratified risk of AP. Association between GPS and time to upgrade on surveillance biopsy was evaluated using Cox proportional hazards models. RESULTS GPS results were obtained for 432 men (median follow-up, 4.6 years); 101 underwent RP after a median 2.1 years of surveillance, and 52 had AP. A total of 167 men (39%) upgraded at a subsequent biopsy. GPS was significantly associated with AP when adjusted for diagnostic GG (hazards ratio [HR]/5 GPS units, 1.18; 95% CI, 1.04 to 1.44; P = .030), but not when also adjusted for prostate-specific antigen density (PSAD; HR, 1.85; 95% CI, 0.99 to 4.19; P = .066). Models containing PSAD and GG, or PSAD, GG, and GPS may stratify risk better than a model with GPS and GG. No association was observed between GPS and subsequent biopsy upgrade ( P = .48). CONCLUSION In our study, the independent association of GPS with AP after initial active surveillance was not statistically significant, and there was no association with upgrading in surveillance biopsy. Adding GPS to a model containing PSAD and diagnostic GG did not significantly improve stratification of risk for AP over the clinical variables alone.