About

Michelle Hamilton is a Professor of Spanish and Portuguese at the University of Minnesota, Twin Cities, where she also serves as the Director of Premodern Studies and leads the Premodern Spanish & Portuguese Studies program. Her teaching encompasses religious studies, Jewish studies, and Spanish literature and culture. She is the Editor of La corónica: A journal of Medieval Hispanic Languages, Literatures, and Cultures. Her research focuses on multi-confessional Iberia, exploring cultural contact, religious and literary traditions, and medieval Iberian cultures. Hamilton has published extensively on topics related to Iberian history, literature, and religious thought, with notable works on Islamic and Judeo-Spanish influences in medieval and early modern Spain. Her educational background includes a PhD in Spanish and Arabic Languages and Literatures from UC Berkeley, a Master's in Hispanic Languages & Literatures from UC Davis, and a Bachelor's in Spanish Language & Literature from the University of Texas, Austin. She has received numerous awards and grants for her scholarly work, including the Medieval Academy of America Centennial Award and the Institute for Advanced Study Research and Creative Grant. Her courses cover a broad range of topics related to medieval Iberia, including its cultures, literature, and religious minorities.

Research topics

• Medicine
• Immunology
• Internal medicine
• Virology

Selected publications

• Localization of mast cells in human brain tissue: Implications for neuropsychiatric symptoms in COVID-19

  Journal of Neuropathology & Experimental Neurology · 2026-03-25

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• Su1089 UTILITY OF THE EPIC HEALTH MAINTENANCE CARE GAP TO IMPROVE ADHERENCE TO COLON CANCER SURVILLANCE GUIDELINES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND PRIMARY SCLEROSING CHOLANGITIS

  Gastrointestinal Endoscopy · 2026-05-01

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• Avapritinib Durably Improves Gastrointestinal Symptoms of Indolent Systemic Mastocytosis: Long-Term Outcomes From the PIONEER Study

  Journal of Allergy and Clinical Immunology · 2026-02-01

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• Cut or Treat: Surgery or Medical Management of Patients with Crohn’s Disease and Evidence of Acute Appendicitis

  Digestive Diseases and Sciences · 2026-03-14

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• 586 AVAPRITINIB DURABLY IMPROVES GASTROINTESTINAL SYMPTOMS OF INDOLENT SYSTEMIC MASTOCYTOSIS: LONG-TERM OUTCOMES FROM THE PIONEER STUDY

  Gastroenterology · 2026-05-01

  articleSenior author
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• Su1089 UTILITY OF THE EPIC HEALTH MAINTENANCE CARE GAP TO IMPROVE ADHERENCE TO COLON CANCER SURVILLANCE GUIDELINES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND PRIMARY SCLEROSING CHOLANGITIS

  Gastroenterology · 2026-05-01

  articleSenior author
  PublisherDOI

• 586 AVAPRITINIB DURABLY IMPROVES GASTROINTESTINAL SYMPTOMS OF INDOLENT SYSTEMIC MASTOCYTOSIS: LONG-TERM OUTCOMES FROM THE PIONEER STUDY

  Gastrointestinal Endoscopy · 2026-05-01

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• Sound of Success: Intestinal Ultrasound in the Management of Refractory Stricturing Crohn’s Disease

  Digestive Diseases and Sciences · 2025-06-25

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• Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features

  American Journal of Medicine Open · 2025-07-18 · 6 citations

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  • Hypermobile Ehlers-Danlos syndrome affects multiple systems, however, a comprehensive analysis of cerebrovascular, autonomic, and neuropathic features in a larger sample is lacking. • This study provided evidence of cerebrovascular dysregulation with reduced orthostatic cerebral blood flow velocity associated with symptoms of cerebral hypoperfusion, frequent small fiber neuropathy, and a widespread but mild autonomic failure in hEDS. Hypermobile Ehlers-Danlos syndrome (hEDS) affects multiple systems, but comprehensive evaluations of a larger sample of hEDS patients are lacking. The objective of this study was to describe cerebrovascular, autonomic, and neuropathic features of hEDS. This retrospective case-control study was conducted at Brigham and Women’s Faulkner Hospital between 2016-2023. Data from hEDS patients who completed autonomic testing and skin biopsies were analyzed. Outcome measures include validated surveys (Survey of Autonomic Functions, Neuropathy Total Symptom Score-6 (SAS)) and autonomic function testing (Valsalva maneuver, deep breathing, head-up tilt and sudomotor), cerebrovascular (cerebral blood flow velocity (CBFv) in the middle cerebral artery), respiratory (capnography), and neuropathic (skin biopsies for assessment of small fiber neuropathy) testing and inflammatory/ autoimmune markers. Total 270 hEDS patients were analyzed and compared to 29 healthy controls. Common hEDS complaints (prevalence > 90% ) were orthostatic sudomotor, vasomotor, gastrointestinal, and pain. Orthostatic cerebral blood flow velocity was reduced in 79% of hEDS and correlated with orthostatic dizziness. The head-up tilt test revealed postural tachycardia syndrome (prevalence 33%), hypocapnic cerebral hypoperfusion (22%), orthostatic cerebral hypoperfusion syndrome (18%), and neurogenic orthostatic hypotension (9%). Widespread but mild autonomic failure was present in 90% of hEDS patients on autonomic testing. Small fiber neuropathy using structural criteria was detected in 64%, and using combined structural and functional criteria in 82%. This study provided evidence of cerebrovascular dysregulation with reduced orthostatic cerebral blood flow velocity associated with symptoms of cerebral hypoperfusion, frequent small fiber neuropathy, and widespread but mild autonomic failure in hEDS.

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• Ileal Signet Ring Adenocarcinoma in Crohn’s Disease: Unanticipated Diagnosis After Surgical Resection of a Symptomatic Stricture

  Digestive Diseases and Sciences · 2024-09-09 · 1 citations

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Recent grants

• An in depth study of mast cell tryptase as a novel mediator in colitis

  NIH · $786k · 2012–2017

Frequent coauthors

• Amitabh Srivastava

  Memorial Sloan Kettering Cancer Center

  106 shared

• Robert D. Odze

  103 shared

• Michael J. Overman

  The University of Texas MD Anderson Cancer Center

  98 shared

• Jayalakshmi Balakrishna

  The Ohio State University

  98 shared

• Iris Simón

  98 shared

• Scott Kopetz

  The University of Texas MD Anderson Cancer Center

  98 shared

• András Ágoston

  University of Nyíregyháza

  98 shared

• Wei Zhou

  Center for Life Sciences

  98 shared

Awards & honors

• The Archive as Infrastructure: Institute for Advanced Study…
• Medieval Academy of America Centennial Award (2024)
• Maurice Amado Foundation Grant (2024)