About

Milan R. Amin, MD, is a professor in the Department of Otolaryngology-Head and Neck Surgery at NYU Grossman School of Medicine. He specializes in treating voice, swallowing, and upper airway disorders, serving as the director of NYU Langone’s Voice Center, which brings together physicians, speech pathologists, and other specialists to improve the lives of patients with these conditions. Dr. Amin is known for his expertise in in-office laryngeal surgery, having performed over 250 laryngeal surgeries annually, and is dedicated to providing compassionate care and rehabilitation to help patients return to their activities and professions. He has been recognized as one of the top physicians in voice disorders and laryngology in the United States, being named in Castle Connolly’s “Top Doctors” series for the New York Metro Area and in New York Magazine’s “Best Doctors in New York” issue. In addition to his clinical work, Dr. Amin actively participates in research, having published more than 70 articles on voice disorders and laryngology, contributing to the advancement of treatment outcomes in his field.

Research topics

• Medicine
• Internal medicine
• Physical therapy
• Surgery
• Demography

Selected publications

• Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With <scp>RRP</scp>

  The Laryngoscope · 2026-01-16 · 3 citations

  articleOpen access

  OBJECTIVE: With regulatory approval of HPV-specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. DATA SOURCES AND METHODS: RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm for adults with RRP considering published literature and commercial drug availability. RESULTS: Preventative HPV vaccination should be considered for all patients. Determination of HPV type and pulmonary imaging are important for contemporary RRP patient care and assist in decision making. Risks and benefits of papilloma debulking as needed versus medical management of RRP must be deliberated on a patient case-by-case basis. HPV-specific immunotherapy that induces an HPV-specific T cell response to target the underlying HPV infection that is the cause of RRP is safe, offers the possibility of durable disease control following a short treatment course and is the recommended first-line medical treatment for patients who wish to avoid the risks of repeat procedural management. Papilloma disease control with systemic bevacizumab, which carries defined risks and must be continued for clinical benefit is the recommended second-line medical treatment for patients who do not achieve a complete response with immunotherapy and wish to continue medical management. For patients who elect to be treated with debulking procedures as needed, use of locally-administered adjuvant should be considered. CONCLUSION: This proposed management algorithm from the RRPF serves as a contemporary resource and information guide for adult patients with RRP and their physicians considering treatment options.

  PublisherOA PDFDOI

• Bilateral vocal fold immobility following head and neck radiotherapy: an institutional review

  The Journal of Laryngology & Otology · 2026-01-30

  articleSenior authorCorresponding

  OBJECTIVES: Bilateral vocal fold immobility is a rare, often delayed complication of head and neck radiotherapy that is not well described in the literature. This study aimed to characterise its timing and clinical course. METHODS: Patients from 2016 to 2024 with prior head and neck radiotherapy, a diagnosis of bilateral vocal fold immobility and no residual disease were reviewed. Data included demographics, tumour site, radiotherapy type/dose, chemotherapy, interval to bilateral vocal fold immobility, airway intervention, nutrition route and mobility recovery. RESULTS: Twelve patients (10 male, 2 female; median age 65.8 years) were identified. Glottic (4, 33.3 per cent) and nasopharyngeal (3, 25 per cent) tumours were the most common. Most (11, 91.7 per cent) received intensity-modulated radiotherapy (median dose 68 Gy); eight had chemoradiation. Median time to bilateral vocal fold immobility was 7.5 years. Seven required tracheostomy (two decannulated); eight needed percutaneous gastric tubes. No patients recovered mobility. CONCLUSION: Bilateral vocal fold immobility following radiotherapy is rare, delayed, often irreversible, and frequently requires tracheostomy and enteral nutrition.

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• <scp>DNA</scp> Immunotherapy ( <scp>INO</scp> ‐3107) Results in Long‐Term Surgery Reduction in <scp>RRP</scp>

  The Laryngoscope · 2025-08-09 · 2 citations

  articleOpen access1st author

  OBJECTIVE: To evaluate the long-term safety and clinical effect of INO-3107 immunotherapy in adults with recurrent respiratory papillomatosis (RRP). METHODS: RRP-002 was a retrospective, observational extension study that followed patients enrolled in the 52-week RRP-001 study. Patients with moderate to severe juvenile or adult-onset RRP who had undergone ≥ 2 surgical interventions in the year preceding dosing were eligible for enrollment in RRP-001. Participants underwent surgical debulking within 14 days prior to initial dosing and then received INO-3107 on Day 0, Weeks 3, 6, and 9. Efficacy assessments during RRP-002 follow-up were the frequency of surgical interventions and alternative medication use. The safety evaluation included reported serious adverse events (SAEs). RESULTS: Twenty-eight (28) of 32 participants from the 52-week RRP-001 study were enrolled in RRP-002. The median follow-up time for RRP-002 was 1.8 years (range: 1.2-2.4 years) for a total median assessment time of 2.8 years (range: 1.0-3.5 years). There were no SAEs or long-term safety concerns identified. The mean number of surgeries was reduced from 4.1 in the pre-treatment period to 1.7 in the first year post-INO-3107 treatment (Year 1) to 0.9 in the second year (Year 2). The complete response rate (0 surgeries per year) increased from 28% (9/32) in Year 1 to 50% (14/28) in Year 2. CONCLUSION: INO-3107 is well tolerated and provides a continued clinical effect against HPV-6 and 11 RRP that results in further reduction of the surgical burden observed in Year 1. These data support the role of INO-3107 immunotherapy for adult patients with RRP. LEVEL OF EVIDENCE: III.

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• Patient Perception of Vocal Tremor Severity and its Relationship to Acoustic Voice Outcomes: An Exploratory Study

  Tremor and Other Hyperkinetic Movements · 2025-01-01

  articleOpen access

  Background: Vocal tremor profoundly impacts communication, social participation, and quality of life. Although expert auditory-perceptual ratings of vocal tremor severity align with acoustic voice outcomes (e.g., extent of frequency (fo) and intensity modulation), patient perception of their voice remains unexamined despite its clinical importance. This study aimed to characterize the relationship between patient-reported vocal tremor severity and acoustic voice outcomes at baseline and after botulinum toxin injections. Method: Patients diagnosed with vocal tremor affecting multiple structures (ETvt) or tremor only observed in the larynx (LDvt) were recruited. Participants completed the voice section of the Quality of Life in Essential Tremor questionnaire to assess patient perception and performed sustained /ɑ/ at a comfortable pitch and volume, from which acoustic voice outcomes (rate and extent of fundamental frequency [fo] and amplitude [dB] modulation) were derived. A subset of participants received botulinum toxin injections and were reassessed within the therapeutic window (within 12 weeks). Results: Thirty participants (29 females; mean age = 72 years, SD = 11.40) were analyzed. Participants who rated their vocal tremor as “severe” demonstrated higher rate fo (β = 1.20, 95% CI: –0.10, 2.60 Hz) and rate dB (β = 2.30, 95% CI: 0.50, 4.10 Hz) compared to participants who rated their tremor as “moderate”. Participants who rated their tremor as “marked” demonstrated higher rate fo (β = 1.50, 95% CI: 0.30, 2.60 Hz) compared to “moderate” ratings. Improvements in patient perception of vocal tremor and acoustic outcomes were highly heterogenous among seven participants who received botulinum toxin. Discussion: Participants reporting more severe vocal tremor demonstrated more aberrant acoustic voice outcomes. After botulinum toxin injection, substantial heterogeneity was observed in acoustic voice measures which varied based on patient perception of change. These preliminary, exploratory findings provide a foundation for future investigations to define meaningful change in this population.

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• Comparing Videofluoroscopic and Patient Reported Outcome Measures of Swallowing After <scp>ACDF</scp> Surgery

  The Laryngoscope · 2025-07-28 · 1 citations

  article

  ABSTRACT Objectives The purpose of this study is to compare findings from videofluoroscopic swallow studies (VFSS) with commonly used patient‐reported outcome tools (PROs) after Anterior Cervical Discectomy and Fusion (ACDF). Our aims were to: (1) determine the impact of ACDF surgery on swallowing and dysphagia symptoms by comparing within‐subject changes pre‐ to six weeks post‐ surgery; (2) compare prevalence, incidence, and rates of clinically meaningful change using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST TM ) and PRO scores; (3) explore how changes across individual PROs align with changes in DIGEST pre‐ to six weeks post‐ surgery. Methods This was a secondary analysis of data from 21 prospectively recruited participants undergoing primary ACDF. VFSS and PRO data was collected preoperatively and six weeks postoperatively. VFSS outcomes included the Modified Barium Swallowing Impairment Profile (MBSImP TM© ) pharyngeal total score and the DIGEST. PROs included the Bazaz Dysphagia Scale, the Eating Assessment Tool (EAT‐10), the Swallowing Quality of Life Questionnaire (SWAL‐QoL), and the Hospital for Special Surgery Dysphagia Index (HSS‐DDI). Results Statistical models for all outcome measures revealed a significant effect of operative timepoint, indicating worse outcomes postoperatively. There were greater postoperative increases in point prevalence and incidence rates using PROs compared with DIGEST. Rates of clinically meaningful change were similar across PROs and DIGEST, but not consistently across the same individual cases. Conclusion This study highlights the difference between physical function and patient experience, suggesting the presence or absence of dysphagia symptoms may not correspond with observed physical impairments after ACDF. Level of Evidence Level III

  PublisherDOI

• The Efficacy of Outpatient Swallowing Therapy: A Retrospective Longitudinal Cohort Study

  Dysphagia · 2025-03-28 · 1 citations

  articleSenior author
  PublisherDOI

• Correlation of the VFSS Esophageal Screen to High‐Resolution Esophageal Manometry

  The Laryngoscope · 2025-03-29 · 3 citations

  articleOpen accessSenior author

  OBJECTIVE: The videofluoroscopic swallow study (VFSS) is an evaluation of the anatomy and physiology of swallowing, and often includes a screening evaluation of the esophagus. How the esophageal screen translates to esophageal pathology remains unknown. The purpose of this study was to determine if abnormal esophageal clearance (EC) on VFSS correlates with esophageal function on high-resolution esophageal manometry (HREM). MATERIALS AND METHODS: This is a retrospective review of 115 adult patients who underwent both VFSS with esophageal screen and HRM. EC on VFSS was scored with the modified barium swallow impairment profile (MBSImP) component 17. Motility was characterized using HRM metrics according to the Chicago Classification Version 4.0 (CCv4.0). Predictive metrics were calculated for the esophageal screen. RESULTS: An EC score o greater than or equal to 1 had a sensitivity of 66%, specificity of 57%, PPV of 52%, NPV of 70%, and OR of 2.55 (p = 0.027). EC weakly correlated with incomplete bolus clearance (rho = 0.331, p = 0.0004) and did not correlate with bolus transit time (rho = 0.17, p = 0.105). CONCLUSIONS: The esophageal screen as characterized by the MBSImP is not an effective predictor of esophageal function on HREM as defined by the CCv4.0. Future work may focus on a defining a standardized VFSS protocol for the esophageal screen and potentially a more nuanced assessment of esophageal findings on VFSS that may enhance the sensitivity of the modality to motility disorders.

  PublisherOA PDFDOI

• An Observational Study of the Prevalence of Oral Human Papilloma Virus Infection in Laryngologists

  The Laryngoscope · 2025-07-30

  articleSenior authorCorresponding

  ABSTRACT Objective Surgical treatment of recurrent respiratory papillomatosis (RRP) has been shown to aerosolize human papillomavirus (HPV), putting healthcare workers at risk for exposure, infection, and disease. Knowledge of HPV infection risk among otolaryngologists who treat HPV‐related diseases is limited. We sought to characterize the prevalence of oral HPV infection in otolaryngologists treating RRP. Methods This observational cohort study enrolled otolaryngologists at a national meeting. Participants completed a survey concerning HPV vaccination, disease history, and practice techniques for patients with RRP. An oral rinse was collected from participants; DNA was extracted and analyzed using commercially available kits. Results A total of 137 participants were included with an average age of 42 years (SD 11); 86 participants (63%) were female. A history of HPV‐related infections, such as cutaneous warts, was reported by 38 participants (28%). About half of the participants ( N = 77, 56%) were vaccinated against HPV. Multiple techniques for managing RRP were reported, including KTP laser ( N = 107), CO 2 laser ( N = 78), microdebrider ( N = 80), and cold steel ( N = 21). Oral rinses from three participants (2.2%) tested positive for HPV, including Subtypes 6 ( N = 2) and 16 ( N = 1). All three were male with no history of HPV vaccination. Conclusion Otolaryngologists treating HPV‐related diseases do not seem to be at a higher risk of HPV infection compared to the general adult population. Vaccination, the use of N95 masks, and minimizing aerosol‐generating techniques are likely protective for healthcare workers dealing with HPV‐related conditions. Level of Evidence 3.

  PublisherDOI

• 1541P DNA immunotherapy (INO-3107) in HPV-6 &amp; 11 recurrent respiratory papillomatosis: Long-term efficacy

  Annals of Oncology · 2025-09-01

  article
  PublisherDOI

• Dysphagia Outcomes in Zenker Diverticulum: A Longitudinal <scp>POuCH</scp> Study

  The Laryngoscope · 2025-08-19 · 1 citations

  articleOpen access

  OBJECTIVE: Patients with cricopharyngeus muscle dysfunction (CPMD) with and without diverticula (e.g., Zenker Diverticulum) often struggle with dysphagia for years prior to diagnosis or intervention. Surgical treatment is successful; yet, there is limited long-term data on dysphagia outcomes after surgery. METHODS: Individuals prospectively enrolled in the Prospective Outcomes of Cricopharyngeal Hypertonicity (POuCH) collaborative with and without diverticula who underwent surgery from November 2014 to August 2024 and had at least 12 months of follow-up were included. Eating Assessment Tool 10 (EAT10) was used to characterize patient-reported outcomes. Descriptive statistics were performed using means, frequencies, and spaghetti plots. RESULTS: Of 164 patients initially identified, 2 withdrew and 2 were excluded for incomplete data; 160 were included. 31% were women, with a mean (SD) age of 70.1 (11.5). Endoscopic surgery (113, 71%) was more common than open technique (47, 29%). 19.4% of patients had undergone previous surgery. Postoperatively, patients were found to have improved EAT-10 scores, with smaller changes recorded after 36 months. Median change in EAT-10 compared to preoperative score was -12 points [IQR: -18, -5] at 12 months. 39 (24%) patients were followed for > 24 months (median change -11 [IQR: -14, -7]); 26 (16%) > 36 months (-9.5 [-17, -5]), and 12 (7.5%) > 48 months (-4 [IQR: -18, 4]). Six patients died during the study period. CONCLUSION: Improved dysphagia after surgery appears stable with minimal change over time. Most patients (96.3%) survive at least 1 year. Surgical intervention for patients with CPMD with or without diverticula is an effective and reliable treatment option.

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Frequent coauthors

• Ryan C. Branski

  New York University

  76 shared

• Gregory N. Postma

  Augusta University

  42 shared

• Peter C. Belafsky

  40 shared

• Gregory R. Dion

  University of Cincinnati

  33 shared

• Albert L. Meratı

  University of Washington Medical Center

  21 shared

• Clark A. Rosen

  University of California, San Francisco

  19 shared

• Pavan S. Mallur

  Harvard University

  18 shared

• Yixin Fang

  AbbVie (United States)

  17 shared

Awards & honors

• Honored as one of the top physicians in voice disorders and…
• Named in Castle Connolly’s “Top Doctors” series for the New…
• Named in New York Magazine’s “Best Doctors in New York” issu…