About

Mousumi Banerjee is an Anant M. Kshirsagar Collegiate Research Professor of Biostatistics and a Research Professor in the Department of Biostatistics at the University of Michigan School of Public Health. She is also a Faculty Affiliate at the Michigan Institute for Data Science and a member of the UM Rogel Cancer Center, the Institute for Healthcare Policy and Innovation, and the Center for Global Health Equity. Her research focuses on developing statistical methodologies and applying them to biomedical research, particularly in cancer and pediatric heart disease. Her methodological work includes predictive modeling, machine learning, causal inference, correlated data, survival analysis, and competing risks, with primary applications to health services and outcomes research. She studies health disparities and issues related to quality and equitable care delivery in the population, working closely with collaborators across fields such as cancer, pediatric heart disease, neurology, surgery, and social determinants of health. Dr. Banerjee received her Bachelor's and Master's degrees in Statistics from the Indian Statistical Institute in Kolkata, India, and her PhD in Statistics from the University of Wisconsin-Madison. She serves as Director of the Pediatric Cardiac Critical Care Consortium (PC4) Analytic Center, a federally funded multi-institutional collaborative aimed at improving care quality for children with critical cardiovascular disease in North America. Additionally, she is the Director of Global StatCore, an initiative to enhance biostatistical support for global public health research, education, and training at UM-SPH in collaboration with international partners.

Research topics

• Medicine
• Emergency medicine
• Internal medicine
• Intensive care medicine
• Artificial Intelligence
• Computer Science
• Pediatrics
• Sociology
• Actuarial science
• Endocrinology
• Virology
• Geography
• Surgery
• Operations research
• Demography
• Econometrics
• Statistics
• Mathematics
• Business
• Pathology
• Economics
• Nursing

Selected publications

• Risk Factors Associated With Central Venous Catheter-Associated Deep Vein Thrombosis After Pediatric Congenital Heart Surgery: An Analysis of the Pediatric Cardiac Critical Care Consortium Registry

  World Journal for Pediatric and Congenital Heart Surgery · 2026-02-05

  article

  Objective: Infants and children undergoing cardiac surgery are one of the highest-risk groups for thrombosis and its sequelae. We sought to define the current rate of and risk factors for postoperative central venous catheter (CVC)-associated deep vein thrombosis (CA-DVT) using the Pediatric Cardiac Critical Care Consortium (PC 4 ) dataset. Design: Retrospective review of PC 4 database from February 2019 to February 2022. Patients: Children <18 years of age admitted for a surgical encounter who had a CVC placed. Results: Included were 33,491 patient encounters, of whom 37.6% (12,582/33,491) were infants (<12 months of age). The overall CA-DVT rate was 2.5% (844/33,491), which varied widely among centers (0-11%). Multivariable analysis showed increased risk of CA-DVT with increasing Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) category (STAT 2 HR 1.8, CI [1.26-2.65]; STAT 3 HR 2.2, CI [1.56-3.39]; STAT 4 HR 2.1, CI [1.55-2.93]; STAT 5 HR 2.5, CI [1.69-3.82]), ( P < .001 for all), low cardiac output syndrome (HR 1.5, CI [1.25-1.91]), P < .001, and postoperative arrhythmia (HR 1.23, CI [1.03-1.47]) P = .024). Patients with CA-DVT were less likely to have an internal jugular vein catheter or intracardiac line and more likely to have an umbilical venous catheter, femoral vein CVC, peripherally inserted CVC, and/or multiple CVCs. Conclusions: CA-DVT remains an important postoperative complication after pediatric cardiac surgery, with greatest risk of occurrence in the younger, smaller, more surgically complex by STAT category, and hemodynamically vulnerable patients. These risk factors must be considered when developing paradigms for CVC placement, thromboprophylaxis, and diagnosis/treatment of CA-DVT in the future.

  PublisherDOI

• Patterns of recurrence in a diverse, population-based sample of adults with early-onset colorectal cancer.

  Journal of Clinical Oncology · 2026-01-10

  article

  43 Background: The incidence of early-onset colorectal cancer (CRC) among adults under 50 has increased by 22% over the past two decades. Despite advances in survivorship care, current guidelines do not adequately address the unique challenges faced by survivors of early-onset CRC, particularly in tailoring surveillance intensity to recurrence risk. This study aimed to characterize recurrence patterns in a diverse, population-based sample to better inform surveillance and survivorship care. Methods: We constructed a population-based cohort of adults <=50 newly diagnosed with stages I-III CRC (2015-2018) and treated with curative-intent surgery from three SEER registries (Georgia, Los Angeles County, and Kentucky, n = 2995). Recurrences were identified through novel methodology utilizing human review of electronic pathology reports, which were then linked to SEER demographic and clinical characteristics. Pathologic-confirmed recurrence was identified in the follow-up period 6 months to five years post-curative intent surgery. Recurrence risk was estimated using proportional hazard regression, adjusting for key demographic and clinical characteristics. Results: Overall, in this population-based sample, 12.5% (n = 373) experienced a pathologic recurrence within five years. Recurrence proportions varied by SEER site: 15% in Georgia, 16% in Kentucky and 7% in California. Recurrence also varied by stage: 6% in stage I, 11% in stage II, and 17% in Stage III. Non-white race/ethnicity, advanced clinical stage, and poor pathologic features were significantly associated with increased recurrence risk (all p < 0.05). Age, biologic sex, poverty, rurality and tumor location were not significantly associated with recurrence. Both Hispanic patients (adjusted HR 1.7, 95% CI: 1.2–2.5) and Black patients (adjusted HR 1.6, 95% CI: 1.2–2.1) had a higher risk of recurrence when compared to white patients. Conclusions: In this diverse, population-based cohort of adults with early-onset CRC, we provide recurrence risk estimates, which also reveal critical disparities by sociodemographic and clinical features. Identifying recurrence patterns and risk phenotypes may enhance current survivorship guidelines and improve outcomes in this growing patient population.

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• Abstract PS2-01-11: Cumulative Medical Costs of Prepectoral versus Subpectoral Implant-Based Breast Reconstruction: A Retrospective Analysis of a Single Academic Center

  Clinical Cancer Research · 2026-02-17

  article

  Abstract Background: Post-mastectomy breast reconstruction is a crucial component in improving psychosocial outcomes and quality of life for breast cancer survivors. Prepectoral implant-based breast reconstruction has gained traction over the past decade due to its potential to enhance aesthetic results and reduce muscle disinsertion-related complications. Wider adoption is limited by concerns over potentially higher healthcare costs compared to the previously traditionally favored subpectoral approach. Prior research on the cost implications of these methods has produced mixed results, often lacking comprehensive analyses of cumulative perioperative medical expenses. Methods: This retrospective cohort study analyzed data from women who underwent unilateral or bilateral mastectomy followed by immediate implant-based reconstruction at a single academic center between July 2017-June 2022. The study period marked a transition in institutional practice from predominantly subpectoral to prepectoral procedures. We examined billing charges from the index surgery and the downstream costs of patient care up to six months post-operation. Regression analyses assessed total index surgery costs, downstream costs, and cumulative costs, adjusting for variables such as age, BMI, and racial demographics. Results: The study analyzed data from 185 patients—86 underwent prepectoral and 99 underwent subpectoral reconstruction. Demographic analysis revealed no significant differences in baseline characteristics such as age, BMI, or intraoperative time between groups. Subpectoral reconstructions had significantly lower index surgery costs, with a 30.5% decrease in costs compared to prepectoral reconstruction (p < 0.001). While downstream costs up to six months post-surgery did not significantly differ, a trend towards reduced expenses was noted following subpectoral procedures (p = 0.094). Cumulative costs, driven by initial surgery expenses, were 29.2% lower in subpectoral cases (Table, p < 0.001). The increased use of acellular dermal matrix in prepectoral procedures was identified as a major factor contributing to higher costs. Conclusions: Our findings demonstrate that prepectoral implant-based reconstruction is associated with significantly higher surgical and cumulative costs compared to subpectoral reconstruction. No substantial differences were observed in postoperative care costs, suggesting that the increased expense of prepectoral approaches is primarily driven by the higher cost of surgical adjuncts during the index surgery. These results provide critical cost-related insights as prepectoral techniques, including the need to use lower-cost surgical adjuncts. Addressing these cost variables could facilitate broader implementation of prepectoral procedures, leveraging their potential patient-centered benefits. Citation Format: D. B. Lipps, B. D. Baglien, M. N. Saunders, J. Vidergar, G. L. Maica, P. L. Myers, M. Banerjee, A. O. Momoh. Cumulative Medical Costs of Prepectoral versus Subpectoral Implant-Based Breast Reconstruction: A Retrospective Analysis of a Single Academic Center [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS2-01-11.

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• Differences in United States Adult Dietary Patterns by Cardiometabolic Health and Socioeconomic Vulnerability

  Journal of Nutrition · 2025-06-09

  articleOpen access

  BACKGROUND: Naturally occurring dietary patterns are not well described among individuals with cardiovascular disease (CVD) or cardiometabolic risk factors (i.e., diabetes, hypertension, obesity, and dyslipidemia), particularly considering socioeconomic vulnerability. OBJECTIVES: We investigated major dietary patterns in the United States and their distribution by prevalent CVD, cardiometabolic risk factors, and socioeconomic vulnerability. METHODS: This cross-sectional study analyzed data from 32,498 noninstitutionalized adults who participated in the National Health and Nutrition Examination Survey (2009-2020). We used principal component analysis to identify dietary patterns. Using multiple linear regression, we tested the association of prevalent CVD, cardiometabolic risk factors, and socioeconomic vulnerability [number of social risk factors and Supplemental Nutrition Assistance Program (SNAP) participation status] with each pattern. RESULTS: Four dietary patterns were identified: processed/animal foods (high-refined grains, added sugars, meats, and dairy), prudent (high vegetables, nuts/seeds, oils, seafood, and poultry), legume, and fruit/whole grain/dairy, which together explained 29.2% of the dietary variance. After adjustment for age, gender, race and ethnicity, cohort year, and total energy intake, the processed/animals foods pattern associated (β-coefficient for difference in principal component score) positively with diabetes [0.08 (0.01, 0.14)], hypertension [0.11 (0.06, 0.16)], obesity [0.15 (0.11, 0.19)], higher social risk score (P-trend < 0.001), income-eligible SNAP nonparticipation [0.16 (0.09, 0.23)], and SNAP participation [0.23 (0.17, 0.29)]. The prudent pattern associated negatively with hypertension [-0.09 (-0.14, -0.04)], obesity [-0.11 (-0.16, -0.06)], higher social risk score (P-trend < 0.001), income-eligible SNAP nonparticipation [-0.14 (-0.21, -0.06)], and SNAP participation [-0.30 (-0.35, -0.24)]. The legume pattern was associated negatively with CVD [-0.09 (-0.15, -0.02)] and obesity [-0.08 (-0.12, -0.04)], and positively with income-eligible SNAP nonparticipation [0.11 (0.04, 0.18)]. The fruit/whole grain/dairy pattern was associated positively with diabetes [0.08 (0.01, 0.15)] and negatively with hypertension [-0.21 (-0.26, -0.15)], obesity [-0.23 (-0.28, -0.18)], higher social risk score (P-trend < 0.001), and SNAP participation [-0.19 (-0.25, -0.12)]. CONCLUSIONS: Empirical dietary patterns in the United States vary by CVD, cardiometabolic risk factors, and socioeconomic vulnerability. Initiatives to improve nutrition should consider these naturally occurring dietary patterns and their variation in key subgroups.

  PublisherDOI

• Epidemiology of SCLC in the United States From 2000 to 2019: A Study Utilizing the Surveillance, Epidemiology, and End Results Registry

  JTO Clinical and Research Reports · 2025-01-20 · 3 citations

  articleOpen access

  Introduction: From the late 1980s to 2000, SCLC represented a decreasing proportion of lung cancer cases in the United States. Nevertheless, survival outcomes in SCLC did not improve, reflecting the paucity of treatment advances. We sought to determine whether these trends continued into more recent decades, before the Food and Drug Administration approval of immunotherapy for SCLC in 2019, by evaluating the incidence and survival of SCLC from 2000 to 2019 in the United States population, with attention to variance across gender and racial subgroups. Methods: Using the United States Surveillance, Epidemiology, and End Results 17 database, we evaluated the incidence of SCLC and NSCLC from 2000 to 2019. Demographic, staging, and survival data were collected for patients with SCLC by comparing the incidence and outcomes across groups. Results: The percentage of SCLC among all newly diagnosed lung cancer cases decreased from 14.5% in 2000 to 11.8% in 2019. A decrease in SCLC incidence was observed in all sex and racial subgroups but was earlier and steeper in men than in women. This has resulted in a shift in the male-to-female ratio from 1.14:1 in 2000 to 0.93:1 in 2019. Among the racial subgroups, the incidence of SCLC declined most slowly in non-Hispanic Whites and most rapidly in non-Hispanic Asians and Pacific Islanders. There was a decline in limited-stage SCLC at diagnosis, from 31.1% in 2000 to 26.4% in 2019. Minimal improvement was observed in survival regardless of patient characteristics or stage. Conclusions: In the preimmunotherapy era of 2000 to 2019, the incidence of SCLC continued to decline in both sexes and all racial subgroups. The male-to-female ratio continued to narrow with women outnumbering men in the most recent years. The proportion of patients with limited-stage disease continues to decline, likely because of improved staging procedures. The outcomes improved slightly but remained poor, highlighting the need for more effective treatment strategies.

  PublisherOA PDFDOI

• 392-P: Metabotypes to Define Cardiorenal Risk in People with Type 1 Diabetes

  Diabetes · 2025-06-13

  article

  Introduction and Objective: Cardio-renal complications are the leading source of morbidity in people with type 1 diabetes (T1D). While previous metabolomic studies have characterized incident and predictive metabolic signatures (metabotypes) of diabetic kidney disease (DKD) and cardiovascular autonomic neuropathy (CAN) in separate T1D cohorts, no previous study has investigated CAN and DKD in the same subset of T1D patients. In this study we sought to identify shared and unique metabotypes of T1DKD and CAN in 120 T1D subjects. Methods: Baseline blood samples were processed for central carbon and lipidomic LC/MS analysis. DKD and CAN were defined as eGFR &amp;lt; 60 mL/min/1.73m2 and/or elevated albumin/creatinine (ACR), and prior validated cut-offs for indices of heart rate variability (SDNN, RMSSD). We used logistic regression to assess ability of metabolic feature/classes associating with incident and progression of DKD and CAN before and after adjusting for age, gender, race, diabetes duration and BMI. Results: Among 120 T1D subjects (mean age 48 years, mean A1c 8.2%; 42 % women) a unique panel of metabolites associated with incident DKD (with amino acids showing AUC of &amp;gt; 0.7 for eGFR and ACR) and CAN (peptides AUC &amp;gt; 0.7). In a subset of subjects with available follow-up data in adjusted analysis baseline azolines and glycerophosphoinositols were associated DKD progression (new decline in eGFR at follow-up &amp;lt; 60 or elevation of ACR compared with baseline). Unadjusted data showed baseline azolines, peptides and steroids may associate with progression of CAN while in adjusted analysis this was no longer significant presumably due to small numbers of subjects that exhibited progression. Conclusion: These data suggest that distinct metabotypes associate with T1D DKD and CAN at baseline, a subset of which associate with DKD progression. Ongoing studies will focus on identifying predictive CAN progression markers as more follow-up data becomes available for risk stratification in people with T1D. Disclosure L. Ang: None. Y. Huang: None. F. Afshinnia: None. M. Banerjee: None. C. Martin: None. P. Ramkumar: None. M. Kretzler: Research Support; AstraZeneca, Boehringer-Ingelheim, Chinook Therapeutics, Inc, Eli Lilly and Company, Moderna, Inc, Janssen Pharmaceuticals, Inc, National Institutes of Health, European Union. Advisory Panel; Novartis Pharmaceuticals Corporation. Research Support; Novo Nordisk. Advisory Panel; Otsuka America Pharmaceutical, Inc. Research Support; Regeneron Pharmaceuticals, Renalytix, Roche Pharmaceuticals, Sanofi, Travere, Certa, Dimerix. S. Pennathur: Research Support; Aurinia. R. Pop-Busui: Board Member; American Diabetes Association. Consultant; Averitas Pharma, Inc. Research Support; Bayer Pharmaceuticals, Inc. Other Relationship; Biogen. Research Support; Juvenile Diabetes Research Foundation (JDRF). Advisory Panel; Lexicon Pharmaceuticals, Inc, Novo Nordisk. Research Support; Novo Nordisk, National Institute of Diabetes and Digestive and Kidney Diseases. Consultant; Roche Diagnostics. Funding Supported by Breakthrough T1D (former JDRF) Center of Excellence grant 2019-861RPB was also supported by 1-R01-DK126837-01A1

  PublisherDOI

• The association of mild cognitive impairment with outpatient visits for hypertension

  Alzheimer s & Dementia · 2025-09-27 · 1 citations

  articleOpen access

  INTRODUCTION: Hypertension management is critically important to reduce the risk of conversion of mild cognitive impairment (MCI) to dementia. The degree to which older adults with hypertension and MCI engage in outpatient ambulatory care for hypertension management is unclear. METHODS: Among older adults with hypertension in the Rush Alzheimer's Disease Center (RADC) cohorts (2011 to 2019), we used repeated measures negative binomial regression to evaluate the association between cognitive status (MCI vs no cognitive impairment [NCI]) and number of annual outpatient clinic visits for hypertension evaluation and management (E&M) (primary outcome). RESULTS: MCI (n = 1013 person-years) was associated with 8% fewer outpatient visits for hypertension versus older adults with NCI (n = 4373 person-years) (relative incidence ratio [RIR] 0.92, p < 0.01). DISCUSSION: Despite the known adverse cognitive effects of hypertension, older adults with MCI may be less likely to engage in outpatient hypertension management. HIGHLIGHTS: Fewer outpatient hypertension visits among adults with MCI versus NCI. Fewer primary care hypertension visits among adults with MCI versus without MCI. Need for interventions to engage adults with hypertension and MCI in outpatient care.

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• A Multimodal Intervention to Increase Total Mesorectal Excision Grading for Rectal Cancer in Michigan: A Randomized Controlled Trial

  Diseases of the Colon & Rectum · 2025-02-28

  article

  BACKGROUND: The total mesorectal excision technique is associated with improved outcomes for rectal cancer, and grading the total mesorectal excision specimen is recommended. We implemented a multimodal intervention in Michigan Surgical Quality Collaborative hospitals to increase total mesorectal excision grading. OBJECTIVE: To compare total mesorectal excision grading rates over time between hospitals that received the intervention early and late in the study. DESIGN: Stepped wedge randomized controlled trial with hospitals randomly assigned to receive the education intervention early in the trial or 1 year later. We used a generalized linear mixed model to compare rates of total mesorectal excision grading over time between groups, adjusting for hospital characteristics. SETTING: Twelve hospitals within the Michigan Surgical Quality Collaborative. PATIENTS: Adult patients undergoing total mesorectal excision for rectal cancer from 2014 to 2021 were included. INTERVENTION: A multimodal educational intervention consisting of a webinar about total mesorectal excision grading, a pre- and postwebinar quiz, and site visits. MAIN OUTCOME MEASURES: Total mesorectal excision grading rate for each hospital over time. RESULTS: From 2014 to 2021, 560 patients underwent total mesorectal excision in participating hospitals: 350 in early intervention hospitals and 210 in late intervention hospitals. The early intervention began in August 2018, and the late intervention began in June 2019. Based on the mixed model, grading in early hospitals increased from 8.1% to 99.7% at the end of the study ( p < 0.001). In the late group, grading increased from 47.8% to 94.0% ( p < 0.001). The intervention was not associated with a change in total mesorectal excision grading in either group; rather, the increase in grading corresponded with a statewide collaborative presentation on this topic in December 2016. LIMITATIONS: Selection bias, as hospitals recruited to participate were already participating in colorectal cancer quality improvement and may reflect greater commitment to high-quality rectal cancer care. CONCLUSIONS: Our findings show an increase in total mesorectal excision grading in Michigan from 2014 to 2021 that preceded the dates of our intervention. These results highlight the importance of accounting for secular trends in measuring health care quality improvement interventions. See Video Abstract . AUMENTO DE GRADACION POR INTERVENCION MULTIMODAL EN LA CLASIFICACIN DE LA EXCISIN TOTAL DEL MESORRECTO EN CASOS DE CNCER DE RECTO EN MICHIGAN ESTUDIO RANDOMIZADO Y CONTROLADO: ANTECEDENTES:La técnica de excisión total del mesorrecto se asocia con mejores resultados en los casos de cáncer recto, y se recomienda aumentar la clasificación de la muestra de excisión mesorrectal total. Implementamos la intervención multimodal en los hospitales de la Colaboración para la Calidad Quirúrgica de Michigan para aumentar la clasificación de la excisión mesorrectal total.OBJETIVO:Comparar los grados en la clasificación de la excisión total del mesorrecto a lo largo del tiempo entre los hospitales que recibieron la intervención al principio y al final del estudio.DISEÑO:Estudio controlado aleatorio y escalonado con hospitales asignados al azar para recibir la intervención educativa al principio del estudio o un año después. Utilizamos un modelo lineal mixto generalizado para comparar las tasas de clasificación en la excisión total del mesorrecto a lo largo del tiempo entre los grupos, ajustando las características del hospital.CONTEXTO:Doce hospitales dentro de la Colaboración de Calidad Quirúrgica de Michigan.PACIENTES:Pacientes adultos sometidos a excisión total del mesorrecto por cáncer de recto entre 2014 y 2021.INTERVENCIÓN:Intervención educativa multimodal que consiste en un seminario - web sobre la clasificación de la excisión total del mesorrecto, un cuestionario previo y otro posterior al seminario - web y visitas al centro.PRINCIPALES MEDIDAS DE RESULTADOS:Los grados de clasificación de la excisión total del mesorrecto para cada hospital a lo largo del tiempo.RESULTADOS:De 2014 a 2021, 560 pacientes se sometieron a una excisión total del mesorrecto en hospitales participantes, 350 en hospitales de intervención temprana y 210 en hospitales de intervención tardía. La intervención temprana comenzó en agosto de 2018 y la intervención tardía comenzó en junio de 2019. Según el modelo mixto, la clasificación en los hospitales que participaron en la intervención temprana aumentó del 8,1 % al 99,7 % al final del estudio ( p < 0,001). En el grupo de intervención tardía, la clasificación aumentó del 47,8 % al 94,0 % ( p < 0,001). La intervención no se asoció con un cambio en la clasificación de la excisión total del mesorrecto en ninguno de los grupos; más bien, el aumento de la clasificación correspondió con la presentación colaborativa a nivel estatal sobre este tema en diciembre de 2016.LIMITACIONES:Sesgo de selección, ya que los hospitales reclutados para participar ya estaban participando en la mejora de la calidad del cáncer colorrectal y podrían reflejar un mayor compromiso con la atención de alta calidad del cáncer rectal.CONCLUSIONES:Nuestros hallazgos muestran un aumento en la clasificación de la excisión total del mesorrecto en Michigan entre 2014 y 2021 precediendo a las fechas de nuestra intervención. Estos resultados destacan la importancia de tener en cuenta las tendencias seculares en la medición de las intervenciones de mejora de la calidad de la atención sanitaria . (Traducción-Dr. Xavier Delgadillo ).

  PublisherDOI

• Differences in US Adult Dietary Patterns by Cardiovascular Health and Socioeconomic Vulnerability

  medRxiv · 2025-01-03

  preprintOpen access

  Background: Naturally occurring dietary patterns, a major contributor to health, are not well described among those with cardiovascular disease (CVD) - particularly in light of socioeconomic vulnerability. We sought to identify major dietary patterns in the US and their distribution by CVD, social risk factors, and Supplemental Nutrition Assistance Program (SNAP) participation. Methods: This was a cross-sectional study among 32,498 noninstitutionalized adults from the National Health and Nutrition Examination Survey (2009-2020). We used principal component analysis to identify common dietary patterns. Individuals were assigned to the pattern for which they had the highest component score. Using multinomial logit regression, we estimated the percentage whose diets aligned with each pattern in population subgroups stratified by CVD, social risk factors, and SNAP. Analyses were adjusted for age, gender, race and ethnicity, total energy intake, and year, with sampling weights to provide nationally representative estimates. Results: Four dietary patterns were identified among US adults: American (33.7%; high in solid fats, added sugars, and refined grains), Prudent (22.6%; high in vegetables, nuts/seeds, oils, seafood, and poultry), Legume (15.8%), and Fruit/Whole Grain/Dairy (27.9%), that together explained 29.2% of dietary variance. More adults with prevalent CVD (37.1%) than without (33.3%, p=0.005) aligned with the American Pattern, with no differences among other patterns. Each additional social risk factor associated with more adults aligned with American (2.5% absolute increase) and Legume (1.3%), and fewer aligned with Prudent (-1.9%) and Fruit/Whole Grain/Dairy (-1.9%) patterns (p<0.001 each). Analysis of dietary patterns across SNAP participation showed higher proportion of SNAP participants and income-eligible SNAP non-participants compared to non-eligible adults for the American (40.2% [38.1, 42.3%], 35.1% [32.7, 37.5%], 31.9% [31.0, 32.8%], respectively) and Legume patterns (17.2% [15.6, 18.8%], 17.8% [16.1, 19.5%]), 15.4% [14.6,16.1%], respectively) and less for Prudent (17.0% [15.5, 18.6%], 20.2% [18.2, 22.3%], 24.2% [23.3, 25.1%], respectively) and Fruit/Whole Grain/Dairy Patterns (25.6% [23.8%, 27.3%], 26.9%[27.6%,29.5%], 28.6% [27.6%, 29.5%], respectively). Conclusions: Empirical dietary patterns vary by CVD and socioeconomic vulnerability. Initiatives to improve nutrition in at-risk individuals should consider these naturally occurring dietary patterns and their variation in key subgroups.

  PublisherOA PDFDOI

• Pregnant hospitalized COVID-19 patients: disease, delivery, maternal and fetal outcomes

  BMC Pregnancy and Childbirth · 2025-10-14 · 1 citations

  articleOpen access

  BACKGROUND: Pregnancy is a risk factor for severe COVID-19, however, the clinical course of pregnant patients hospitalized due COVID-19 is not well documented. We sought to prospectively assess outcomes of pregnant patients hospitalized for COVID-19, including pregnancy outcomes for mother and infant. METHODS: ) patients to examine the association of pregnancy with a composite outcome of in-hospital death and the use of mechanical or non-mechanical respiratory support. Manual chart review of the electronic medical record was conducted to ascertain pregnancy and infant outcomes. RESULTS: Pregnant women hospitalized for COVID-19 (n = 54) were more likely to have higher body-mass index, asthma, and obstructive sleep apnea compared to matched-pregnant women who tested positive for COVID-19 but were non-hospitalized (n = 216). Eighteen (33%) pregnant patients hospitalized for COVID-19 (n = 54) exhibited the composite outcome, as well as 36 (17%) of matched non-pregnant women (n = 216). In-hospital mortality was similar between both groups; 2/54 (4%) pregnant vs. 6/216 (3%) non-pregnant women (P = 0.66). However, pregnant women had a higher likelihood of requiring respiratory support (OR 3.42, (95% CI [1.64, 7.13]) compared to non-pregnant women, driven by increased use of non-mechanical ventilation for 10/54 pregnant vs. 11/216 non-pregnant women (19% vs. 5%, respectively). Pregnant women in the third trimester (> 27 weeks) experienced the composite outcome (13/29) more often than those hospitalized for COVID-19 earlier in pregnancy (< = 27 weeks) (5/21) (45% vs. 24%). Of the eight pregnant women requiring mechanical ventilation (15%), one was vaccinated and seven were unvaccinated. Of those who delivered during their COVID-19 hospitalization (16/54), cesarean section was required for 75% of deliveries (12/16), 69% (11/16) were delivered preterm (< 37 weeks 0 days), and 44% (7/16) required admission to the neonatal intensive care unit immediately following birth. CONCLUSIONS: Pregnant women hospitalized for COVID-19 may experience differences in clinical care and medical treatment received compared to non-pregnant women, including higher rates of non-invasive respiratory support. Pregnant women may be more likely to experience higher rates of preterm birth and infants may be more likely to need neonatal intensive care. Maternal outcomes from COVID-19 hospitalization may worsen as pregnancy progresses to later trimesters. Lower likelihood of experiencing poor outcomes may be attributed to vaccination.

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Recent grants

• NIH Grant R21CA152775

  NIH · $354k · 2014

Frequent coauthors

• Brian C. Callaghan

  University of Michigan–Ann Arbor

  122 shared

• Lesli E. Skolarus

  Northwestern University

  84 shared

• Eva L. Feldman

  Johns Hopkins University

  74 shared

• Evan L. Reynolds

  Michigan State University

  65 shared

• Michael Gaies

  University of Cincinnati

  62 shared

• Melissa A. Elafros

  University of Michigan–Ann Arbor

  51 shared

• Thair Dawood

  Hurley Medical Center

  49 shared

• David P. Wood

  Beaumont Health

  49 shared

Awards & honors

• Fellow of the American Statistical Association
• Elected Member of the International Statistical Institute