About
Noa Krugliak Cleveland, MD, is a board-certified physician specializing in gastroenterology with advanced training in inflammatory bowel disease (IBD). She sees patients with ulcerative colitis and Crohn’s disease and is interested in the use of novel therapies to treat IBD, as well as new technologies for the detection and management of cancer and inflammation in IBD, including bedside intestinal ultrasound. Alongside her clinical expertise, Dr. Krugliak Cleveland is a physician-scientist whose research focuses on disease outcomes and prevention of IBD complications. She investigates the application of new technology for the detection and prevention of IBD progression, contributing to the field through her publications in peer-reviewed journals.
Research topics
- Gastroenterology
- Internal medicine
- Medicine
- Surgery
- Intensive care medicine
Selected publications
Sa1525 PROGNOSTIC VALUE OF EARLY ENDOSCOPIC FINDINGS IN ILEAL POUCH-ANAL ANASTAMOSIS OUTCOMES
Gastroenterology · 2026-05-01
articleCrohn s & Colitis 360 · 2026-04-25
articleOpen accessSenior authorBackground: Intestinal ultrasound (IUS) has been studied to assess therapeutic response in patients with acute severe ulcerative colitis (ASUC). However, there is no data on sonographic changes occurring in ASUC receiving intravenous (IV) cyclosporine. This case series aims to describe the sonographic changes occurring in hospitalized patients with ASUC receiving IV cyclosporine as salvage therapy. Methods: This is a retrospective observational study in a single tertiary care center from February 2023 to May 2024. Serial sonographic findings of patients with severe UC treated with IV cyclosporine were collected. Sonographic changes associated with clinical outcomes were analyzed. Outcomes included clinical response (Simple Clinical Colitis Activity Index decrease of ≤3 at day 3 with discharge on oral cyclosporine) and colectomy. Results: Nine patients received IV cyclosporine with IUS monitoring; 67% failed ≥2 advanced therapies. Four responded to cyclosporine, four underwent colectomy, and one switched to upadacitinib with a subsequent response during the same admission. Clinical responders had a median 31.8% (IQR 26.3-51.2) reduction in bowel wall thickness (BWT) and 1-scale reduction in modified Limberg score, whereas non-responders demonstrated 7.2% (IQR 54.8-9.0) reduction in BWT and no change in modified Limberg score. The median time to clinical response was 2.5 days (IQR 1.8-2.6). Baseline BWT was similar between responders and non-responders: 5.2 mm (IQR 3.5-6.5) versus 5.2 mm (3.8-6.7). Conclusions: A median 31.8% BWT reduction was observed by day 3 among responders, highlighting early sonographic changes associated with response to IV cyclosporine therapy in refractory ASUC.
Gastroenterology · 2026-05-01
articleSenior authorGastrointestinal Endoscopy · 2026-05-01
articleSenior authorSa1525 PROGNOSTIC VALUE OF EARLY ENDOSCOPIC FINDINGS IN ILEAL POUCH-ANAL ANASTAMOSIS OUTCOMES
Gastrointestinal Endoscopy · 2026-05-01
articleACG Case Reports Journal · 2026-02-01
articleOpen accessEndoscopic balloon dilation is an established option for the management of fibrostenosing Crohn's disease (CD). Transmural assessment by cross-sectional imaging in addition to endoscopy is imperative for the management of patients with stenoses. Intestinal ultrasound (IUS) is a noninvasive, relatively inexpensive, point-of-care disease monitoring tool being incorporated into daily clinical practice in inflammatory bowel disease. With the rise in IUS utilization in the management of CD, there are opportunities to understand the pathophysiology of this condition and its treatment in new ways. We describe the first successful IUS-guided endoscopic balloon dilation in a patient with fibrostenotic CD who presented with bowel obstruction.
Universität Zürich, ZORA · 2026-02-13
articleOpen accessThe Lancet. Gastroenterology & hepatology · 2026-05-01
articleInflammatory Bowel Diseases · 2025-10-15
articleOpen accessBACKGROUND: Mesenteric fat (MF) wrapping is a characteristic feature of Crohn's disease (CD). Current assessment methods are limited to binary classification (presence/absence), restricting their utility in assessing disease progression and treatment response. This study aimed to develop and validate a novel semi-quantitative metric for grading MF wrapping using intestinal ultrasound (IUS), and to evaluate its reliability and clinical relevance. METHODS: This cross-sectional study included 95 ultrasound scans from 63 patients with CD. The novel index described here categorized MF wrapping into 3 categories: none, incomplete, and complete. Images were independently assessed to evaluate inter- and intrarater reliability. Associations between MF wrapping and clinical characteristics, inflammatory markers, and IUS parameters were analyzed. RESULTS: Interrater reliability for the MF index was moderate (κ = 0.452), while intrarater reliability was substantial (κ = 0.653), similar to binary assessment (κ = 0.572 and κ = 0.674 for inter- and intrarater reliability, respectively). MF wrapping was significantly associated with increased bowel wall thickness (OR, 6.74; P < .001), loss of bowel wall stratification (OR, 22.05; P < .001), hyperemia (OR, 8.09; P = .002), and presence of strictures (OR, 4.30; P = .002). Smoking status and lower serum albumin were significantly associated with increased MF wrapping. CONCLUSIONS: CMFI represents a proof-of-concept tool for semi-quantitative assessment of MF wrapping on IUS. While reproducible and associated with other disease markers, its incremental clinical utility remains to be established through prospective validation and longitudinal outcome studies.
Ulcerative colitis: moving beyond the mucosal dogma
The Lancet. Gastroenterology & hepatology · 2025-10-28 · 5 citations
review
Frequent coauthors
- 107 shared
David T. Rubin
- 27 shared
Russell D. Cohen
- 26 shared
Sushila Dalal
University of Chicago
- 23 shared
Joel Pekow
University of Chicago
- 22 shared
Natalie K. Choi
- 16 shared
Ninfa Candela
Takeda (United States)
- 15 shared
Atsushi Sakuraba
Hokkaido University
- 14 shared
David Choi
University of Chicago
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