About

Paul P. Huang, MD, is an Associate Professor in the Department of Neurosurgery at NYU Grossman School of Medicine and serves as the Site Director and Chief at Bellevue. His medical education was completed at Columbia University in 1989, and he completed his residency in Neurosurgery at NYU Medical Center in 1996. He is board certified by the American Board of Neurological Surgery since 1998. Dr. Huang's clinical focus includes treating conditions such as arteriovenous malformation, astrocytoma, brain aneurysm, cerebrovascular disorder, hydrocephalus, spinal cord tumor, and traumatic brain injury, with a particular emphasis on spinal cord procedures. His research interests and scholarly contributions include neurosurgical trauma, cerebrovascular disorders, and brain tumors, as evidenced by his publications in neurosurgery and related fields.

Research topics

• Medicine
• Internal medicine
• Surgery
• Radiology
• Virology
• Law
• Medical emergency

Selected publications

• Basilar artery perforator rupture as the cause of perimesencephalic subarachnoid hemorrhage

  Journal of neurosurgery · 2026-01-01

  article

  OBJECTIVE: The cause of perimesencephalic subarachnoid hemorrhage (pmSAH) is unclear but has historically been attributed to a venous source. The authors hypothesized that high-resolution cone-beam CT (CBCT) during angiography could better identify pmSAH etiology. METHODS: All patients with pmSAH treated at the authors' institution between January 2023 and December 2024 were retrospectively analyzed. Patients were excluded if CBCT was not performed as part of the digital subtraction angiography (DSA), if CBCT source data were not available for review, or if the images were deemed to be low quality. All images were reviewed by 2 neuroangiographers with extensive neurovascular imaging experience and discussed until consensus agreement. Data were recorded as counts and percentages. RESULTS: Among 152 patients who presented with spontaneous SAH in 2023-2024, 22 had a pmSAH defined according to the Rinkel criteria. These 22 patients had a catheter angiogram performed on 1 of 2 biplane machines. Thirteen of those patients had high-quality CBCT data available for review, 8 (61%) of whom were found to harbor a basilar perforator focal outpouching consistent with a site of rupture. All patients with pmSAH, including the 8 found to have a basilar perforator aneurysm, achieved an excellent neurological recovery with resolution of the basilar perforator finding on follow-up DSA with CBCT and without experiencing a re-rupture event or clinically significant vasospasm. CONCLUSIONS: In the setting of pmSAH, high-resolution CBCT acquired as part of catheter angiography frequently identifies a basilar perforator pseudoaneurysm. Conservative management was associated with excellent outcomes in this series. The authors propose that in the setting of pmSAH, a high suspicion of an arterial etiology should be considered until proven otherwise.

  PublisherDOI

• Basilar artery perforator rupture as the cause of perimesencephalic subarachnoid hemorrhage.

  Open Access CRIS of the University of Bern · 2026-01-23

  articleOpen access

  Objective The cause of perimesencephalic subarachnoid hemorrhage (pmSAH) is unclear but has historically been attributed to a venous source. The authors hypothesized that high-resolution cone-beam CT (CBCT) during angiography could better identify pmSAH etiology.Methods All patients with pmSAH treated at the authors' institution between January 2023 and December 2024 were retrospectively analyzed. Patients were excluded if CBCT was not performed as part of the digital subtraction angiography (DSA), if CBCT source data were not available for review, or if the images were deemed to be low quality. All images were reviewed by 2 neuroangiographers with extensive neurovascular imaging experience and discussed until consensus agreement. Data were recorded as counts and percentages.Results Among 152 patients who presented with spontaneous SAH in 2023-2024, 22 had a pmSAH defined according to the Rinkel criteria. These 22 patients had a catheter angiogram performed on 1 of 2 biplane machines. Thirteen of those patients had high-quality CBCT data available for review, 8 (61%) of whom were found to harbor a basilar perforator focal outpouching consistent with a site of rupture. All patients with pmSAH, including the 8 found to have a basilar perforator aneurysm, achieved an excellent neurological recovery with resolution of the basilar perforator finding on follow-up DSA with CBCT and without experiencing a re-rupture event or clinically significant vasospasm.Conclusions In the setting of pmSAH, high-resolution CBCT acquired as part of catheter angiography frequently identifies a basilar perforator pseudoaneurysm. Conservative management was associated with excellent outcomes in this series. The authors propose that in the setting of pmSAH, a high suspicion of an arterial etiology should be considered until proven otherwise.

  PublisherDOI

• Outpatient Follow-up After Pediatric Traumatic Brain Injury at an Urban Safety Net Hospital: A Retrospective Cohort Study

  Child s Nervous System · 2025-07-10

  article
  PublisherDOI

• 2061 Trends and Outcomes of Electric and Mechanical Bike and Scooter Accidents in an Urban Center

  Neurosurgery · 2025-03-14

  articleSenior author

  INTRODUCTION: The rising use of personal mobility devices (PMDs) such as mechanical and electric bikes and scooters in urban centers around the world has transformed the public transportation landscape in many cities. We performed a study to assess characteristics, neurologic injury, and outcomes of patients involved in PMD accidents over a five-year period in Manhattan. METHODS: We performed a five-year retrospective cohort study of all patients that presented to a level-1 trauma center from 2018 to 2023 with an associated PMD accident. RESULTS: A total of 914 patients presented following a PMD accident between 2018 and 2023. The number of patients presenting with PMD related trauma increased over time, as well as the proportion of patients using electric PMDs compared to mechanical.Individuals on electric PMDs were more likely to wear a helmet (30% vs 22.9%, p=0.0197). Individuals on mechanical PMDs were more likely to sustain a head injury (50.9% vs 42.6%, p=0.0177) and were more likely to be admitted to the hospital (70.5% vs 62.4%, p=0.0129). Electric bike riders had a higher average GCS on arrival compared to mechanical bike riders (14.8 vs 14.2, p=0.039). The most common mechanism of injury involved a bike rider being hit by a car. CONCLUSIONS: Patients riding mechanical bikes presented with more serious neurologic injuries when compared to individuals on electric bikes. The most common presentation was following a bike being hit by a car. This study allows us to identify locations, times, patterns, and presenting characteristics that are associated with more severe outcomes and enables us to enact public safety measures to improve urban transportation safety in the future.

  PublisherDOI

• Eye tracking for classification of concussion in adults and pediatrics

  Frontiers in Neurology · 2022-12-01 · 15 citations

  articleOpen accessSenior author

  Introduction: In order to obtain FDA Marketing Authorization for aid in the diagnosis of concussion, an eye tracking study in an intended use population was conducted. Methods: Potentially concussed subjects recruited in emergency department and concussion clinic settings prospectively underwent eye tracking and a subset of the Sport Concussion Assessment Tool 3 at 6 sites. The results of an eye tracking-based classifier model were then validated against a pre-specified algorithm with a cutoff for concussed vs. non-concussed. The sensitivity and specificity of eye tracking were calculated after plotting of the receiver operating characteristic curve and calculation of the AUC (area under curve). Results: = 282) was 31.6%. Conclusion: A pre-specified algorithm and cutoff for diagnosis of concussion vs. non-concussion has a sensitivity and specificity that is useful as a baseline-free aid in diagnosis of concussion. Eye tracking has potential to serve as an objective "gold-standard" for detection of neurophysiologic disruption due to brain injury.

  PublisherOA PDFDOI

• Remodeling of the Posterior Cerebral Artery P1-Segment after Pipeline Flow Diverter Treatment of Posterior Communicating Artery Aneurysms

  Neurology International · 2021-05-07 · 12 citations

  articleOpen access

  Introduction: Flow diverters such as the pipeline embolization device (PED) cause hemodynamic changes of the treated vessel segment. In posterior communicating artery (PcomA), aneurysms’ unique anatomic consideration have to be taken in account due to the connection between the anterior and posterior circulation. We hypothesize that in conjunction with PcomA remodeling, there will also be remodeling of the ipsilateral P1 segment of the posterior cerebral artery (PCA) after PED treatment for PcomA aneurysms. Methods: We retrospectively collected radiological as well as clinical data of PcomA aneurysm patients treated with PED including PcomA and P1 vessel diameters before and after treatment as well as patient and aneurysm characteristics. Results: Overall, 14 PcomA aneurysm patients were included for analysis and PED treatment was performed without complications in all patients. In 10 out of 14 patients (71%), a decrease in PcomA diameter was observed and there was a significant mean decrease of 0.78 mm in PcomA diameter on angiographic last follow-up (LFU) (p = 0.003). In the same patient population (10 out of 14 patients), there was meanwhile a significant mean increase of 0.43 mm in the ipsilateral P1 segment diameter observed (p = 0.015). These vessel remodeling effects were in direct correlation with aneurysm occlusion since all of these patients showed aneurysm occlusion at LFU while 29% showed only partial occlusion without vessel remodeling effects. A decrease in PcomA diameter was directly associated with aneurysm occlusion (p = 0.042). There were no neurologic complications on LFU. Conclusion: In the treatment of PcomA aneurysms with PED, the P1 segment of the PCA increases in diameter while the PcomA diameter decreases. Our results suggest that this remodeling effect is associated with aneurysm occlusion and decrease of PcomA is hemodynamically compensated for by an increase in the ipsilateral P1 diameter.

  PublisherOA PDFDOI

• Radiosurgery for Unruptured Intervention-Naïve Pediatric Brain Arteriovenous Malformations

  Neurosurgery · 2021-11-18

  article

  Chen, Ching-Jen MD; Lee, Cheng-Chia MD, PhD; Kano, Hideyuki MD, PhD; Kearns, Kathryn N BS; Ding, Dale MD; Tzeng, Shih-Wei MD; Atik, Ahmet Fatih MD; Joshi, Krishna MD; Huang, Paul P MD; Kondziolka, Douglas MD; Ironside, Natasha MBChB; Mathieu, David MD; Iorio-Morin, Christian MD, PhD; Grills, Inga S MD; Quinn, Thomas J MD; Siddiqui, Zaid A MD; Marvin, Kim BS; Feliciano, Caleb MD; Starke, Robert M MD, MSc; Faramand, Andrew MD; Barnett, Gene MD; Lunsford, L Dade MD; Sheehan, Jason P MD, PhD, on behalf of the International Radiosurgery Research Foundation

  PublisherDOI

• Effect of Prior Embolization on Outcomes After Stereotactic Radiosurgery for Pediatric Brain Arteriovenous Malformations: An International Multicenter Study

  Neurosurgery · 2021-07-24 · 18 citations

  article

  BACKGROUND: Pediatric brain arteriovenous malformations (AVMs) are a significant cause of morbidity but the role of multimodal therapy in the treatment of these lesions is not well understood. OBJECTIVE: To compare the outcomes of stereotactic radiosurgery (SRS) with and without prior embolization for pediatric AVMs. METHODS: We retrospectively evaluated the International Radiosurgery Research Foundation pediatric AVM database. AVMs were categorized, based on use of pre-embolization (E + SRS) or lack thereof (SRS-only). Outcomes were compared in unadjusted and inverse probability weight (IPW)-adjusted models. Favorable outcome was defined as obliteration without post-SRS hemorrhage or permanent radiation-induced changes (RIC). RESULTS: The E + SRS and SRS-only cohorts comprised 91 and 448 patients, respectively. In unadjusted models, the SRS-only cohort had higher rates of obliteration (68.5% vs 43.3%, < .001) and favorable outcome (61.2% vs 36.3%, P < .001) but a lower rate of symptomatic RIC (9.0% vs 16.7%, P = .031). The IPW-adjusted rates of every outcome were similar between the 2 cohorts. However, cumulative obliteration rates at 3, 5, 8, and 10 yr remained higher in the absence of prior embolization (46.3%, 64.6%, 72.6%, and 77.4% for SRS-only vs 24.4%, 37.2%, 44.1%, and 48.7% for E + SRS cohorts, respectively; SHR = 0.449 [0.238-0.846], P = .013). CONCLUSION: Embolization appears to decrease cumulative obliteration rates after SRS for pediatric AVMs without affecting the risk of post-treatment hemorrhage or adverse radiation effects arguing against the routine use of pre-SRS embolization. While endovascular therapy can be considered for occlusion of high-risk angioarchitectural features prior to SRS, future studies are necessary to clarify its role.

  PublisherDOI

• Impact of COVID‐19 pandemic on STEMI care: An expanded analysis from the United States

  Catheterization and Cardiovascular Interventions · 2020 · 91 citations

  • Medicine
  • Medical emergency
  • Virology

  OBJECTIVE: To evaluate the impact of COVID-19 pandemic migitation measures on of ST-elevation myocardial infarction (STEMI) care. BACKGROUND: We previously reported a 38% decline in cardiac catheterization activations during the early phase of the COVID-19 pandemic mitigation measures. This study extends our early observations using a larger sample of STEMI programs representative of different US regions with the inclusion of more contemporary data. METHODS: Data from 18 hospitals or healthcare systems in the US from January 2019 to April 2020 were collecting including number activations for STEMI, the number of activations leading to angiography and primary percutaneous coronary intervention (PPCI), and average door to balloon (D2B) times. Two periods, January 2019-February 2020 and March-April 2020, were defined to represent periods before (BC) and after (AC) initiation of pandemic mitigation measures, respectively. A generalized estimating equations approach was used to estimate the change in response variables at AC from BC. RESULTS: Compared to BC, the AC period was characterized by a marked reduction in the number of activations for STEMI (29%, 95% CI:18-38, p < .001), number of activations leading to angiography (34%, 95% CI: 12-50, p = .005) and number of activations leading to PPCI (20%, 95% CI: 11-27, p < .001). A decline in STEMI activations drove the reductions in angiography and PPCI volumes. Relative to BC, the D2B times in the AC period increased on average by 20%, 95%CI (-0.2 to 44, p = .05). CONCLUSIONS: The COVID-19 Pandemic has adversely affected many aspects of STEMI care, including timely access to the cardiac catheterization laboratory for PPCI.

  PublisherOA PDFDOI

• Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States During COVID-19 Pandemic

  Journal of the American College of Cardiology · 2020-04-10 · 1212 citations

  letterOpen access
  PublisherOA PDFDOI

Frequent coauthors

• Jason P. Sheehan

  University of Virginia Health System

  96 shared

• Hideyuki Kano

  96 shared

• L. Dade Lunsford

  University of Pittsburgh Medical Center

  95 shared

• Douglas Kondziolka

  New York University

  91 shared

• Caleb Feliciano

  University of Puerto Rico System

  86 shared

• Timothy D. Henry

  Pfizer (United States)

  83 shared

• Inga S. Grills

  Beaumont Health

  83 shared

• Emerson C. Perin

  University of Connecticut

  82 shared

Labs

• NYU Langone Health Neurosurgery LabPI