Paulo Gomes
· Clinical Associate Professor, DermatologyVerifiedPurdue University · Department of Veterinary Clinical Sciences
Active 1990–2025
Research topics
- Medicine
- Biochemistry
- Organic chemistry
- Immunology
- Chromatography
- Internal medicine
- Bioinformatics
- Biology
- Waste management
- Nuclear chemistry
- Chemistry
Selected publications
Frontiers in Veterinary Science · 2025-02-19
articleOpen accessUnderstanding the impact of environmental and management factors on the health and behavior of dogs housed in commercial breeding (CB) facilities is critical to their welfare. The specific aims of the study were to assess (a) associations between combinations of flooring substrates commonly used in CB kennels with foot, elbow, or hock abnormalities such as pododermatitis, calluses, or interdigital furuncle and (b) the impact of flooring substrate on dog cleanliness. Dogs ( N = 373) from CB facilities ( N = 20), housed on combinations of concrete, gravel, and diamond-coated expanded metal were assessed. A veterinary dermatologist examined each dog's paw, toenails, elbows, hocks, body condition, and overall cleanliness. Identified conditions included wet paws (12.6%), calluses (11.26%), erythema (6.97%), and matted paw fur (6.17%). Mixed-effects logistic regression models identified an effect of sex and wet paws (OR 6.08, CI 1.23, 29.92, p = 0.03) and age with matted paw fur (OR 1.52, CI 1.12, 2.07, p = 0.007). A few conditions were identified, including pododermatitis, hygromas, and interdigital furuncles, where management alterations might result in improved outcomes and welfare states for dogs in CB facilities.
Feline immune-mediated skin disorders: Part 1
Journal of Feline Medicine and Surgery · 2025-04-01 · 3 citations
reviewOpen accessPRACTICAL RELEVANCE: Cutaneous immune-mediated diseases in cats can present with clinical signs of erythema, hair loss, scaling/crusting and erosions with or without pruritis, mimicking many differential diagnoses such as hypersensitivity dermatitis and infections (eg, parasitic and fungal dermatitis). Veterinarians are encouraged to become familiar with the characteristic clinical features of various immune-driven skin disorders to permit early diagnosis and appropriate treatment. CLINICAL CHALLENGES: Diagnosis and therapeutic management of feline immune-mediated skin diseases can be challenging. Although immune-mediated skin diseases in cats are rare, these can be associated with severe systemic clinical signs, which can lead to poor quality of life and owners electing euthanasia. AIMS: In the first of a two-part article series, the clinical presentations of feline immune-mediated skin diseases related to the pemphigus complex, cutaneous lupus erythematosus, and thymoma- and non-thymoma-associated exfoliative dermatitis are reviewed and differential diagnoses, diagnosis and therapeutic approach are discussed. In Part 2, the equivalent is discussed for erythema multiforme, f Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum, plasma cell pododermatitis, proliferative and necrotizing otitis externa, pseudopelade, alopecia areata and auricular chondritis. EVIDENCE BASE: The information in this article is based on a review of the existing veterinary literature.
Revista Brasileira de Terapias Cognitivas · 2025-01-01
articleOpen accessSenior authorFeline immune-mediated skin disorders: Part 2
Journal of Feline Medicine and Surgery · 2025-04-01 · 1 citations
reviewOpen accessPractical relevanceCutaneous immune-mediated diseases in cats can present with clinical signs of erythema, hair loss, scaling/crusting, and erosions with or without pruritus, mimicking many differential diagnoses such as hypersensitivity dermatitis and infections (eg, parasitic and fungal dermatitis). Veterinarians are encouraged to become familiar with the characteristic clinical features of various immune-driven skin disorders to permit early diagnosis and appropriate treatment.Clinical challengesDiagnosis and therapeutic management of feline immune-mediated skin diseases can be challenging. Although immune-mediated skin diseases in cats are rare, these can be associated with severe systemic clinical signs, which can lead to poor quality of life and owners electing euthanasia.AimsIn the second of a two-part article series, the clinical presentations of the feline immune-mediated skin diseases erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum, plasma cell pododermatitis, proliferative and necrotizing otitis externa, pseudopelade, alopecia areata and auricular chondritis are reviewed and differential diagnoses, diagnosis and therapeutic approach are discussed. In Part 1, the equivalent is discussed for feline immune-mediated skin diseases related to the pemphigus complex, cutaneous lupus erythematosus, and thymoma- and non-thyoma-associated exfoliative dermatitis.Evidence baseThe information in this article is based on a review of the existing veterinary literature.
2024
Senior authorCorresponding- Medicine
Journal of Molecular Liquids · 2024 · 16 citations
- Chemistry
- Nuclear chemistry
- Chromatography
Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis
Metabolites · 2021 · 14 citations
- Medicine
- Immunology
- Internal medicine
Lipids play a critical role in the skin as components of the epidermal barrier and as signaling and antimicrobial molecules. Atopic dermatitis in dogs is associated with changes in the lipid composition of the skin, but whether these precede or follow the onset of dermatitis is unclear. We applied rapid lipid-profiling mass spectrometry to skin and blood of 30 control and 30 atopic dogs. Marked differences in lipid profiles were observed between control, nonlesional, and lesional skin. The lipid composition of blood from control and atopic dogs was different, indicating systemic changes in lipid metabolism. Female and male dogs differed in the degree of changes in the skin and blood lipid profiles. Treatment with oclacitinib or lokivetmab ameliorated the skin condition and caused changes in skin and blood lipids. A set of lipid features of the skin was selected as a biomarker that classified samples as control or atopic dermatitis with 95% accuracy, whereas blood lipids discriminated between control and atopic dogs with 90% accuracy. These data suggest that canine atopic dermatitis is a systemic disease and support the use of rapid lipid profiling to identify novel biomarkers.
Does Flooring Substrate Impact Kennel and Dog Cleanliness in Commercial Breeding Facilities?
Animals · 2018-04-21 · 17 citations
articleOpen accessEvaluation of kennel flooring surfaces is needed to understand their impacts on dog health and well-being. This pilot study aimed to characterize aspects of physical health, kennel cleanliness, and dog body cleanliness on flooring types common in US breeding kennels. Subjects were 118 adult dogs housed on diamond-coated expanded metal (DCEM), polypropylene (POLY), or concrete (CON) flooring at five commercial breeding facilities in Indiana, U.S. Body condition, paw, elbow, and hock health scores were recorded. Each indoor kennel and dog was visually assessed for cleanliness. Kennels were swabbed immediately after cleaning with electrostatic dry cloths and cultured for Escherichia coli. Descriptive statistics were used for analysis. Mean body condition score (BCS), kennel and dog cleanliness scores were all near ideal (3, 1.15, and 1.04, respectively). Thirty-one percent or fewer kennels at each facility were culture-positive for E. coli after cleaning. No serious paw, elbow, or hock problems were identified. Overall, the findings indicate that with appropriate management and regular access to additional surfaces, dog foot health, cleanliness, and kennel cleanliness can be maintained on the flooring types investigated.
Disponibilidade de fosforo nos fosfatos de Tapira e fosforindus e na farinha de ossos para suinos.
infoteca-e (Brazilian Agricultural Research Corporation) · 2003-06-18 · 2 citations
articleOpen access1st authorCorrespondingFosfatos de rocha em dietas para suínos formuladas com base no fósforo disponível
Americanae (AECID Library) · 1991-10-01 · 1 citations
articleOpen accessRealizou-se um experimento objetivando avaliar diferentes fontes de fosfatos para suínos. Utilizaram-se 144 suínos mestiços (Landrace x Large White) de ambos os sexos, dos 22 aos 99,2 kg. Os tratamentos, dispostos num delineamento inteiramente casualizado, foram representados pelas dietas à base de milho e farelo de soja e fosfatos bicálcico, tapira, patos ou goiás. As dietas foram equivalentes em proteína, energia digestível e P disponível. 0 desempenho dos suínos alimentados com as dietas contendo os fosfatos bicálcico e tapira foi semelhante (P > 0,05). Entretanto, o fosfato bicálcico diferiu (P < 0,05) e, o fósfato de tapira foi similar (P > 0,05) aos que receberam fosfatos patos e goiás. O ganho de peso diário médio e a conversão alimentar dos animais foram: 804 e 2,83; 750 e 2,89; 650 e 2,88; 629 g e 3,04, respectivamente. A percentagem de cinza no terceiro metacarpiano diferiu (P < 0,05) entre os fosfatos testados, e os valores foram, respectivamente, 49,80; 50,43; 52,29 e 48,46%. As concentrações de flúor nos fosfatos patos e goiás devem ser diminuídas, para permitir seu melhor aproveitamento nas dietas para suínos.
Frequent coauthors
- 2 shared
Judith L. Stella
Purdue University West Lafayette
- 2 shared
José O. Fernandes
Universidade do Porto
- 2 shared
C. Bellaver
- 2 shared
M. F. M. Gomes
- 2 shared
Sara C. Cunha
Rede de Química e Tecnologia
- 1 shared
Audrey Ruple
Virginia–Maryland College of Veterinary Medicine
- 1 shared
Guilherme Isquibola
Universidade Estadual Paulista (Unesp)
- 1 shared
Jackeline Franco
IDEXX Laboratories (United States)
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