About

Dr. Pierre F. Lespinasse completed his Obstetrics and Gynecology training at New Jersey Medical School, now part of Rutgers University. He is an Associate Professor of Practice in the Department of Obstetrics, Gynecology and Reproductive Health at Rutgers New Jersey Medical School. Dr. Lespinasse's practice encompasses all areas of general gynecology with a special interest in pelvic organ prolapse, urinary incontinence, and vaginal hysterectomy for fibroids. He is responsible for the division of Female Pelvic Medicine and Reconstructive Surgery, which provides surgical and non-surgical management to women with bladder prolapse, uterine prolapse, or rectal prolapse, as well as evaluating and treating women with urinary incontinence. He is board certified in both Obstetrics and Gynecology and Female Pelvic Medicine and Reconstructive Surgery. Dr. Lespinasse holds an MD degree from Universite d'Etat d'Haiti and is licensed to practice medicine in New Jersey. He is fluent in French and Spanish.

Research topics

• Medicine
• Surgery
• Internal medicine
• Gynecology

Selected publications

• Co-occurrence of a Mullerian anomaly and Kallmann syndrome: A case report

  Case Reports in Women s Health · 2025-02-04

  articleOpen access

  The evaluation of primary amenorrhea requires a thoughtful assessment for hormonal, structural and/or genetic causes. Although most cases of primary amenorrhea are caused by a single pathology, rarely multiple pathologies may be uncovered. We present the case of a 33-year-old woman with a history of pubertal failure and primary amenorrhea due to Kallmann syndrome. She reported previous short-term use of hormone replacement therapy, with onset of severe pelvic pain and vaginal bleeding following its discontinuation. Her workup revealed concern for uterine didelphys with OHVIRA syndrome on MRI. Surgical exploration revealed a normal-appearing vagina and cervix communicating with the left uterine horn and fallopian tube, a separate, contralateral, obstructed, and engorged right uterine horn with cervix and obstructed vagina, and normal ovaries bilaterally. She underwent laparoscopic resection of the obstructed right hemiuterus with right salpingectomy. Estrogen replacement therapy was initiated postoperatively with cyclic progestins, and she experienced complete resolution of her pain. In the workup of primary amenorrhea, it is important to consider that more than one pathology may be present. A thorough endocrine, genetic, and anatomic evaluation is imperative prior to confirming the diagnosis and initiating treatment. Kallmann syndrome has rarely been reported with Mullerian anomalies; in this case it represents a scenario in which the induction of puberty and menses brought an obstructive anomaly to light. The possibility of co-occurring pathologies should always be considered to provide optimal care to the patient.

  PublisherDOI

• Brenner Tumor of the Ovary in a Patient With Postmenopausal Bleeding: A Case Report

  Cureus · 2024-08-25 · 1 citations

  articleOpen access

  Brenner tumors are ovarian epithelial tumors that can be benign, borderline, or malignant. This report highlights a case of a patient with postmenopausal bleeding and elevated estradiol associated with a Brenner tumor. A 59-year-old woman, menopausal for seven years, presented with postmenopausal bleeding for the past month. An ultrasound done four years prior to presentation revealed a right adnexal mass likely to be a fibrous lesion. An office endometrial biopsy done at the time of presentation showed a weakly proliferative endometrium. The patient was then prescribed a course of medroxyprogesterone acetate therapy. Because of persistent bleeding, the patient was scheduled for a hysteroscopy and dilation and curettage. An exam under anesthesia confirmed a firm, palpable mass in the right adnexa and a normal uterine cavity. Endometrial curetting indicated proliferative endometrium. After hysteroscopy and biopsy, a pelvic sonogram showed a 5.8 x 4.3 x 4.2 cm solid right adnexal mass. Serum estradiol was measured at 137.0 pg/mL. The patient was then scheduled for a laparoscopic hysterectomy with bilateral salpingo-oophrectomy, with final pathology of the right adnexal mass revealing a Brenner tumor. The patient had an uncomplicated postoperative course. Patients with persistent postmenopausal bleeding require further evaluation; if not caught early, postmenopausal estrogen production by tumors may be associated with concomitant endometrial cancer.

  PublisherOA PDFDOI

• Does Living With Human Immunodeficiency Virus Increase Pelvic Reconstructive Surgery Perioperative Complication Risk? A Multicenter Retrospective Cohort Study

  Female Pelvic Medicine & Reconstructive Surgery · 2020

  • Medicine
  • Surgery
  • Internal medicine

  OBJECTIVE: To determine if women with human immunodeficiency virus (HIV) undergoing pelvic reconstructive surgery (PRS) have an increased risk of perioperative and postoperative complications compared with HIV-negative controls. STUDY DESIGN: Multicenter, retrospective matched cohort study of patients with and without HIV infection who underwent PRS between 2006 and 2016. Cases were identified using International Classification of Disease, 9th edition Clinical Modification and 10th edition Clinical Modification and current procedural terminology (CPT) codes encompassing HIV diagnoses and pelvic reconstructive surgeries. Controls were identified as patients without HIV who underwent similar procedures, performed by the same surgeon during the same 1-year period as surgeries performed on patients with HIV. Cases were matched to controls at a ratio of 1:3. The primary outcome was composite complication rate within 1 year of surgery. RESULTS: Sixty-three patients with HIV and 187 controls were identified. There was no difference in the composite complication rate between women with HIV and HIV-negative women (36.5% vs 30.0%, P = 0.15) over 1 year. However, 19.1% of patients with HIV compared with 5.4% controls had Clavien Dindo Grade I complications (P = 0.002), and 11.1% of HIV patients had urinary retention within 6 weeks of surgery compared with 3.2% of controls (P = 0.02). After multivariable logistic regression used to adjust for confounders, living with HIV was not associated with an increased risk of complications. CONCLUSIONS: Patients living with HIV are not at an increased risk of complications within 1 year of PRS compared with patients without HIV.

  PublisherDOI

• A Case of Uterine Volvulus: A Case Report and Review of the Literature

  Journal of Gynecologic Surgery · 2020

  Senior authorCorresponding
  • Medicine
  • Surgery
  • Gynecology

  Background: Uterine volvulus is a rare occurrence, especially in non-gravid uteri. Uterine volvulus can lead to ischemia and necrosis when left undetected. Case: A 73-year-old woman with acute abdominal pain and known history of fibroid uterus underwent an exploratory laparotomy showing a uterine volvulus, which resulted in uterine and adnexal necrosis. Results: The patient's pain, which was secondary to torsion of her uterus, resolved after hysterectomy and bilateral salpingo-oophorectomy. Conclusion: Uterine volvulus, although rare, is a gynecological emergency that should be detected quickly to prevent severe morbidity and to conserve fertility in reproductive-age women.

  PublisherDOI

• Ovarian Endometrioma with Osseous Metaplasia: A Case Report and Review of the Literature

  Journal of Gynecologic Surgery · 2019-04-23 · 1 citations

  article

  Abstract Background: Osseous metaplasia of the nonteratomatous ovary is extremely rare. This condition has been reported in association with endometriosis and certain ovarian neoplasms. Case: A 35-year-old nulliparous patient presented with new-onset severe abdominal pain associated with abdominal fullness, nausea, and vomiting. She had a large, tender pelvic mass anterior to the cervix. Computed tomography showed a midline pelvic mass, measuring 13.1 × 12.3 × 9.3 cm, located anteriorly and superiorly to the uterine fundus, with partially calcified septations as well as an eccentric soft-tissue nodule The uterus was enlarged and lobulated, containing multiple fibroids. There was a complex cystic mass superior to the uterus producing low-level internal echoes and having a few septations with areas of calcification. The patient underwent an exploratory laparotomy during which the pelvic mass was identified as an endometrioma arising from the left ovary. The cyst was densely adherent to the superior aspect of a leiomyomatous uterus with a large fundal fibroid measuring ∼7 cm. Intraoperative pathologic evaluation revealed that this cyst was benign. Lysis of adhesions, followed by myomectomy, was performed, removing 19 fibroids weighing 235 g in aggregate. Results: The patient had an uncomplicated postoperative course and was referred for infertility evaluation. Pathologically, this lesion was consistent with an endometriotic cyst (endometrioma) with focal osseous metaplasia. Conclusions: It has been theorized that chronic inflammation might be a driving force in the formation of bone within these lesions.

  PublisherDOI

• Decidual Emboli After Uterine Perforation

  International Journal of Surgical Pathology · 2018-12-14

  article
  PublisherDOI

• Differential regulation of IFNα, IFNβ and IFNε gene expression in human cervical epithelial cells

  Cell & Bioscience · 2017-11-02 · 8 citations

  articleOpen access

  Interferonε (IFNε) is a unique type I IFN that has distinct functions from IFNα/β. IFNε is constitutively expressed at mucosal tissues, including the female genital mucosa, and is reported to be modulated by estrogen and seminal plasma. However, its regulation by cytokines, including TNFα, IL-1β, IL-6, IL-8, IL-17, IL-22 and IFNα, which are commonly present in the female genital mucosa, is not well documented in freshly isolated primary cervical cells from tissues. We determined the effect of these cytokines on gene expression of type I IFNs in an immortalized endocervical epithelial cell line (A2EN) and in primary cervical epithelial cells. Several pro-inflammatory cytokines were found to induce IFNε, and TNFα induced the strongest response in both cell types. Pretreatment of cells with the IκB inhibitor, which blocks the NF-κB pathway, suppressed TNFα-mediated IFNε gene induction and promoter activation. Expression of IFNα, IFNβ, and IFNε was differentially regulated in response to various cytokines. Taken together, our results show that regulation of these IFNs depends on cell type, cytokine concentration, and incubation time, highlighting the complexity of the cytokine network in the cervical epithelium.

  PublisherOA PDFDOI

• Massive Cellular Angiofibroma of the Vulva

  Journal of Lower Genital Tract Disease · 2017-04-21 · 7 citations

  article

  In Brief Cellular angiofibromas of the vulva are uncommon and usually small and circumscribed. A massive, infiltrative, cellular angiofibroma extending into the pelvis is described.

  PublisherDOI

• Retained Seton Presenting as a Perineal Abscess

  Journal of Lower Genital Tract Disease · 2016-12-20

  article1st author

  From the Departments 1Obstetrics, Gynecology, and Women's Health and 2Pathology and Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ Correspondence to: Debra S. Heller, MD, Department of Pathology-UH/E158, Rutgers-New Jersey Medical School, 185 S Orange Ave, Newark, NJ, 07103. E-mail: [email protected] The authors have declared they have no conflicts of interest.

  PublisherDOI

• Multinucleated Atypia of the Vulva: A Mimic of Human Papillomavirus Infection

  Journal of Gynecologic Surgery · 2016-11-14

  article

  Background: An uncommon finding is the presence of multinucleated cells in the squamous epithelium of the vulva, unrelated to human papillomavirus (HPV) infection. Most likely a result of inflammation, these cells have been seen within the basal-to-middle layers of the squamous epithelium. This finding can be mistaken for evidence of HPV infection. Case: This article describes the case of a woman in her 30s who presented with chronic vulvar pruritus and whose condition remained unresponsive to multiple rounds of anticandidal therapy. Results: Vulvar biopsy showed multinucleated atypia in a setting of squamous-cell hyperplasia (lichen simplex chronicus). Conclusions: A pitfall to avoid is classifying these multinucleated cells as evidence of HPV infection. (J GYNECOL SURG 33:41)

  PublisherDOI

Frequent coauthors

• Debra S. Heller

  38 shared

• Barry E. Perlman

  8 shared

• Carley Tasker

  Regeneron (United States)

  7 shared

• Emily E. Weber LeBrun

  University of Florida

  6 shared

• Theresa L. Chang

  Rutgers New Jersey Medical School

  6 shared

• Diana Santiago

  Rutgers, The State University of New Jersey

  4 shared

• Noel Kowal

  Rutgers New Jersey Medical School

  4 shared

• David Sheyn

  University Hospitals of Cleveland

  4 shared

Education

• M.D.

  New Jersey Medical School

• M.D.

  Universite d'Etat d'Haiti

  1992