About

Scott Campbell is an Associate Professor of Urban Planning at the Taubman College of Architecture and Urban Planning at the University of Michigan. He directed the Doctoral Urban Planning Program for ten years and is a Senior Fellow at the Michigan Society of Fellows. His academic specialization includes planning theory, sustainability, economic development, and regional planning. Campbell's publications include 'The Rise of the Gunbelt: The Military Remapping of Industrial America' published by Oxford University Press, and the 'Readings in Planning Theory / Readings in Urban Theory' series (Wiley, 3 editions). His work on sustainable development has been recognized with a National Planning Award from the American Planning Association. He studied urban planning (Ph.D., MCP) at the University of California, Berkeley, and Environmental Earth Sciences and German at Stanford University (BAS), with additional education at the Technische Universität Berlin through DAAD and the Freie Universität Berlin.

Research topics

• Artificial Intelligence
• Computer Science
• Political Science
• Pharmacology
• Biochemistry
• Biology
• Chemistry
• Medicine
• Internal medicine
• Engineering
• Management science
• Geography
• Virology
• Psychology
• Data science
• Management
• Social psychology
• Epistemology

Selected publications

• Clinical Decision Support Systems in Spaceflight Operations

  WORLD SCIENTIFIC eBooks · 2024-04-01

  book-chapterSenior author
  PublisherDOI

• Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

  Nature Communications · 2024-09-27 · 11 citations

  articleOpen access

  Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in children and immunocompromised people. There is only one approved treatment that is modestly effective for children and ineffective for AIDS patients. Here, screening 278 compounds from the Merck KGaA, Darmstadt, Germany collection and accelerated follow-up enabled by prior investigation of the compounds identifies a series of pyrazolopyrimidine human phosphodiesterase (PDE)-V (hPDE-V) inhibitors with potent anticryptosporidial activity and efficacy following oral administration in C. parvum-infected male mice. The lead compounds affect parasite host cell egress, inhibit both C. parvum and C. hominis, work rapidly, and have minimal off-target effects in a safety screening panel. Interestingly, the hPDE-V inhibitors sildenafil and the 4-aminoquinoline compound 7a do not affect Cryptosporidium. C. parvum expresses one PDE (CpPDE1) continuously during asexual growth, the inhibited life stage. According to homology modeling and docking, the lead compounds interact with CpPDE1. Bulkier amino acids (Val900 and His884) in the CpPDE1 active site replace alanines in hPDE-V and block sildenafil binding. Supporting this, sildenafil kills a CRISPR-engineered Cryptosporidium CpPDE1 V900A mutant. The CpPDE1 mutation also alters parasite susceptibility to pyrazolopyrimidines. CpPDE1 is therefore a validated pyrazolopyrimidine molecular target to exploit for target-based optimization for improved anticryptosporidial development.

  PublisherOA PDFDOI

• Identification of potent and orally efficacious phosphodiesterase inhibitors in s <i>Cryptosporidium parvum-</i> infected immunocompromised mice

  bioRxiv (Cold Spring Harbor Laboratory) · 2023-09-26

  preprintOpen access

  Abstract Cryptosporidium species, mostly C. parvum and C. hominis in humans, are intestinal apicomplexan parasites that cause life-threatening diarrhea in young children and people with cell-mediated immune defects, such as due to AIDS. There is only one approved treatment for cryptosporidiosis, but it is ineffective for immunocompromised people and only modestly effective for children. In this study, screening 278 compounds from the Merck KGaA, Darmstadt, Germany collection and accelerated follow-up work enabled by prior investigation of the compounds resulted in identification of a series of pyrazolopyrimidine human phosphodiesterase (PDE)-V inhibitors with potent anticryptosporidial activity and efficacy following oral administration in C. parvum -infected immunocompromised mice. The novel PDE inhibitor leads ( compounds PDEi2 and PDEi5 ) affect parasite egress from infected host cells. They have comparable activity against C. parvum and C. hominis , rapidly eliminate C. parvum in tissue culture, and have minimal off-target effects in a panel of safety screening assays. In comparison, the potent human PDE-V inhibitors sildenafil and the 4-aminoquinoline compound 7a have no useful activity against C. parvum. Based on homology modeling and in silico compound docking, PDEi5 interacts directly with an active-site metal ion and docks well to two C. parvum PDEs. In contrast, larger amino acid side groups (Val900/Tyr11128 and His884/Asn1112) in both C. parvum PDEs replace alanine in human PDE-V and block sildenafil binding, explaining its lack of efficacy. These results identify a promising new drug target and lead series for anticryptosporidial drug development and validates a route to target-based optimization.

  PublisherOA PDFDOI

• The Planner’s Pentangle: A Proposal for a Twenty-First-Century Model of Plannin <u>g</u>

  Journal of Planning Education and Research · 2023-03-31 · 6 citations

  articleSenior author

  The planner’s triangle—the model that visually defined planning as the balance of equity, economy, and environment to achieve sustainability—has influenced theory, practice, and pedagogy for a quarter of a century. We argue that the triangle requires updating. Even if sustainability remains the center of planning’s conceptual model, the vertices must be rethought. We propose a planner’s pentangle with five priorities as vertices: Wellness, Equity, Economy, Environment, and Esthetics (WE 4 ). The pentangle concept represents planning’s history more comprehensively. It also more accurately represents the state of planning in the twenty-first century when health/wellness and cultural/esthetic concerns are increasingly important.

  PublisherDOI

• Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2

  European Journal of Medicinal Chemistry · 2022 · 12 citations

  • Chemistry
  • Pharmacology
  • Virology
  PublisherOA PDFDOI

• Track 5: Design of Interconnected Infrastructure Systems for Resilient and Sustainable Communities

  2022-09-14

  preprint
  PublisherDOI

• Weinbaum, Alys Eve. <b><i>The Afterlife of Reproductive Slavery: Biocapitalism and Black Feminism’s Philosophy of History</i></b>

  Women s Studies · 2021-09-27

  article1st authorCorresponding

  In the current moment, the predominance of biotechnology is difficult to ignore. This can be seen most vividly in a world collectively holding its breath in anticipation of a vaccine for COVID-19, ...

  PublisherDOI

• Planning: Green Cities, Growing Cities, Just Cities? Urban Planning and the Contradictions of Sustainable Development

  2021-12-13 · 7 citations

  book-chapter1st authorCorresponding

  This chapter discusses the simple triangular model to understand the divergent priorities of planning. If the property conflict is characterized by the economy's ambivalent interest in providing at least a subsistence existence for working people, and the resource conflict by the economy's ambivalent interest in providing sustainable conditions for the natural environment, the development conflict stems from the difficulty of doing both at once. In other words, the development conflict can be resolved only if the property conflict is resolved as well. The challenge for poor communities is now to expand their work on the property conflict to address the development conflict as well that is, to challenge the false choice of jobs over the environment. The current environmental enthusiasm among planners and planning schools might suggest their innate predisposition to protect the natural environment. In an ideal world, planners would strive to achieve a balance of all three goals.

  PublisherDOI

• Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin

  Journal of Medicinal Chemistry · 2021 · 19 citations

  • Chemistry
  • Pharmacology
  • Biochemistry

  Cryptosporidiosis is caused by infection of the small intestine by Cryptosporidium parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is only partially effective in young children and ineffective for immunocompromised patients. Triazolopyridazine MMV665917 is a previously reported anti-Cryptosporidium screening hit with in vivo efficacy but suffers from modest inhibition of the hERG ion channel, which could portend cardiotoxicity. Herein, we describe our initial development of structure–activity relationships of this novel lead series with a particular focus on optimization of the piperazine-urea linker. We have discovered that piperazine-acetamide is a superior linker resulting in identification of SLU-2633, which has an EC50 of 0.17 μM, an improved projected margin versus hERG, prolonged pharmacokinetic exposure in small intestine, and oral efficacy in vivo with minimal systemic exposure. SLU-2633 represents a significant advancement toward the identification of a new effective and safe treatment for cryptosporidiosis.

  PublisherOA PDFDOI

• Pacific Realm: Economic Geography II

  2020-01-01

  articleSenior author
  Publisher

Frequent coauthors

• Joel Quam

  45 shared

• Sabina Deitrick

  16 shared

• Ann Markusen

  University of Minnesota

  15 shared

• Peter Hall

  Simon Fraser University

  14 shared

• Leila Amini

  Berlin Institute of Health at Charité - Universitätsmedizin Berlin

  12 shared

• Kamlesh Patel

  University of Birmingham

  12 shared

• Michał Macech

  Medical University of Warsaw

  12 shared

• Andrew Ready

  Queen Elizabeth Hospital Birmingham

  12 shared

Education

• Ph.D., Urban Planning

  University of Michigan

  2000

• M.S., Urban Planning

  University of Michigan

  1995

• B.A., City and Regional Planning

  University of California, Berkeley

  1990

Awards & honors

• National Planning Award from the American Planning Associati…
• 2018 Douglas Haskell Award for Student Journals