About

George Sen is a Professor of Dermatology at UC San Diego. His research focuses on understanding the molecular mechanisms of epidermal stem cell self-renewal and differentiation. He investigates the factors that regulate these processes, which are crucial for maintaining skin homeostasis and preventing human skin disorders. Perturbations in the balance between growth and differentiation can lead to hyperproliferative disorders such as psoriasis and skin cancers like basal and squamous cell carcinomas. His work emphasizes identifying epigenetic factors that promote epidermal stem cell functions and characterizing novel regulators of epidermal homeostasis. His ultimate goal is to define all regulators involved in stem cell self-renewal, differentiation, and tumorigenesis, with the aim of developing better treatments for skin disorders. His research areas include developmental biology, genetics and genomics, gene expression and regulation, and stem cell biology. Dr. Sen has contributed significantly to the field through his investigations into post-transcriptional regulation, epigenetic regulation, and signaling pathways that influence epidermal proliferation, differentiation, and immune responses, advancing the understanding of skin biology and disease.

Research topics

• Physical chemistry
• Organic chemistry
• Chemistry
• Photochemistry
• Crystallography
• Inorganic chemistry
• Materials science
• Nanotechnology
• Chemical engineering
• Stereochemistry

Selected publications

• Dissymmetrical Chiral Peropyrenes: Synthesis via Iridium-Catalyzed C–H Activation/Alkyne Benzannulation and Study of Their Properties

  The Journal of Organic Chemistry · 2024 · 9 citations

  1st authorCorresponding
  • Chemistry
  • Photochemistry
  • Crystallography

  region.

  PublisherOA PDFDOI

• Nanographene Cathode Materials for Nonaqueous Zn-Ion Batteries

  Journal of The Electrochemical Society · 2022 · 1 citations

  • Materials science
  • Nanotechnology
  • Inorganic chemistry

  Robust multivalent ion interaction in electrodes is a grand challenge of next-generation battery research. In this manuscript, we design molecularly-precise nanographene cathodes that are coupled with metallic Zn anodes to create a new class of Zn-ion batteries. Our results indicate that while electrodes with graphite or flat nanographenes do not support Zn-ion intercalation, the larger intermolecular spacing in a twisted peropyrene enables peropyrene electrodes to facilitate reversible Zn-ion intercalation in an acetonitrile electrolyte. While most previous Zn-ion batteries utilize aqueous electrolytes, the finding that nonaqueous Zn electrolytes can support intercalation in nanographenes is important for expanding the design space of nonaqueous multivalent batteries, which often possess higher voltages than their aqueous counterparts. Furthermore, because these nanographenes can be synthesized using a bottom-up approach via alkyne benzannulation, this work paves the way for future battery electrodes that contain other molecularly-precise nanographenes with tailored electrochemical properties.

  PublisherDOI

• CCDC 1002992: Experimental Crystal Structure Determination

  The Cambridge Structural Database · 2015-01-01

  datasetOpen access1st authorCorresponding

  An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  PublisherDOI

• CCDC 1002405: Experimental Crystal Structure Determination

  The Cambridge Structural Database · 2015-01-01

  datasetOpen access1st authorCorresponding

  An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  PublisherDOI

• CCDC 1001904: Experimental Crystal Structure Determination

  The Cambridge Structural Database · 2015-01-01

  datasetOpen access1st authorCorresponding

  An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  PublisherDOI

• CCDC 1001902: Experimental Crystal Structure Determination

  The Cambridge Structural Database · 2015-01-01

  datasetOpen access1st authorCorresponding

  An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  PublisherDOI

• Organometallic Photobase Generators and Computational Investigations of the Isomeric Preference of Unsaturated Metal Carbonyl and Metal Isocyanide Complexes

  2014-01-01

  articleOpen access1st authorCorresponding

  ClinicalTrials.Gov Identifier: NCT01321554.

  PublisherOA PDFDOI

• Development of [CpRu(η6-benzylcarbamate)]X salts as two-stage photobase generators

  Inorganica Chimica Acta · 2014-07-09 · 2 citations

  article1st authorCorresponding
  PublisherDOI

• Synthesis of a cobalt(iv) ketimide with a squashed tetrahedral geometry

  Chemical Communications · 2013-01-01 · 45 citations

  article

  Oxidation of [Li(THF)]2[Co(N=C(t)Bu2)4] with 1 equiv. of I2 generates Co(N=C(t)Bu2)4 in 85% yield. In the solid-state, this complex exhibits a squashed tetrahedral structure about the Co center. DFT calculations reveal this geometry arises, in part, to maximize ketimide-to-cobalt π-donation.

  PublisherDOI

Frequent coauthors

• Joshua S. Figueroa

  University of California, San Diego

  6 shared

• Alex E. Carpenter

  University of Minnesota

  5 shared

• James M. Blackwell

  5 shared

• Arnold L. Rheingold

  University of California, San Diego

  5 shared

• Curtis E. Moore

  The Ohio State University

  5 shared

• Ryan J. Malone

  2 shared

• Wesley A. Chalifoux

  University of Alberta

  2 shared

• Jonas Spengler

  1 shared

Education

• B. A., Chemistry

  Florida Gulfcoast university