About

Dr. Basil S. Hubbi is a board-certified radiologist and the section chief of breast imaging and intervention since 2009 at Rutgers New Jersey Medical School. He has served as the radiology residency program director since 2015. His clinical responsibilities include breast imaging and body imaging, and he has grown as a breast imager through the years, emphasizing a multidisciplinary approach to patient care. Dr. Hubbi has also taken on leadership roles in clinical administration and graduate medical education, and has participated in grant-supported community outreach efforts. His research focuses on the comparison of measurements of invasive breast carcinomas on ultrasound imaging versus final pathology reports, investigating the reliability of different imaging modalities and the influence of hormone receptor status on tumor size assessment, aiming to improve treatment planning and understanding of breast cancer pathology.

Research topics

• Radiology
• Surgery
• Medicine
• Pathology

Selected publications

• Influence of Exercise on Inferior Vena Cava Wall Interaction with Inferior Vena Cava Filters: Results of a Pilot In Vivo Porcine Study

  The Arab Journal of Interventional Radiology · 2022 · 1 citations

  • Medicine
  • Radiology
  • Surgery

  Objectives The aim of this study was to assess the effect of mild exercise on inferior vena cava (IVC) filter interaction with imaging and pathological features with the neighboring vessel wall utilizing a porcine model. Materials and Methods After Institutional Animal Care and Use Committee (IACUC) approval, retrievable Option Elite IVC filters were implanted in six Yorkshire pigs utilizing the right common femoral vein approach under general anesthesia. Group A ( n =4) pigs remained sedentary for 4 weeks. Group B ( n =2) pigs were exercised using a harness and treadmill for 10minutes/day for 4 days/week. At approximately 4 weeks, IVC venograms were performed and the pigs were sacrificed. After laparotomy, the IVC was ligated above and below the filter, excised and fixed in formalin. Gross and histological examination of the IVC was performed. Gross images of each sample were captured before removal of the filters. One longitudinal, one tangential, and five transverse representative sections were processed for paraffin sectioning and hematoxylin and eosin slides were prepared. A pathologist examined all tissues to assess differences between normal vein, group A and group B pigs. The pathologist provided an overall assessment and representative images. Results All IVC filter implantations were technically successful without adverse effects. There was no incidence of caval thrombosis, filter strut fracture, or filter migration in either group. On gross pathological examination, IVC of the pigs in group B demonstrated more perivascular and mural fibrosis than those pigs in group A. Histopathological findings correlated with gross findings. Conclusions In this pilot study, there were no incidence of IVC filter strut fracture, penetration or IVC occlusion in sedentary or exercised pigs. However, there tended to be more perivascular and mural fibrosis on pathological examination of inferior vena cavas from exercised pigs. Further larger scale studies may employ the porcine model to further understand the role exercise may play on IVC filter and caval wall interaction.

  PublisherOA PDFDOI

• A Phase I trial using local regional treatment, nonlethal irradiation, intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect

  Journal of Hepatocellular Carcinoma · 2017-08-01 · 30 citations

  articleOpen access

  Purpose: To determine the safety of an approach to immunologically enhance local treatment of hepatocellular cancer (HCC) by combining nonlethal radiation, local regional therapy with intratumoral injection, and systemic administration of a potent Toll-like receptor (TLR) immune adjuvant. Methods: Patients with HCC not eligible for liver transplant or surgery were subject to: 1) 3 fractions of 2-Gy focal nonlethal radiation to increase tumor antigen expression, 2) intra-/peri-tumoral (IT) injection of the TLR3 agonist, polyinosinic-polycytidylic acid polylysine carboxymethylcellulose (poly-ICLC), to induce an immunologic “danger” response in the tumor microenvironment with local regional therapy, and 3) systemic boosting of immunity with intramuscular poly-ICLC. Primary end points were safety and tolerability; secondary end points were progression-free survival (PFS) and overall survival (OS) at 6 months, 1 year, and 2 years. Results: Eighteen patients with HCC not eligible for surgery or liver transplant were treated. Aside from 1 embolization-related severe adverse event, all events were ≤grade II. PFS was 66% at 6 months, 39% at 12 months, and 28% at 24 months. Overall 1-year survival was 69%, and 2-year survival 38%. In patients <60 years old, 2-year survival was 62.5% vs. 11.1% in patients aged >60 years ( P <0.05). Several patients had prolonged PFS and OS. Conclusion: Intra-tumoral injection of the TLR3 agonist poly-ICLC in patients with HCC is safe and tolerable when combined with local nonlethal radiation and local regional treatment. Further work is in progress to evaluate if this approach improves survival compared to local regional treatment alone and characterize changes in anticancer immunity. Keywords: immunotherapy, autologous vaccine, liver cancer, human trial, Toll-like receptor

  PublisherOA PDFDOI

• TU-AB-204-02: Device Adverse Events and Compliance

  Medical Physics · 2016-06-01

  article1st authorCorresponding

  The responsibilities of the Food and Drug Administration (FDA) have increased since the inception of the Food and Drugs Act in 1906. Medical devices first came under comprehensive regulation with the passage of the 1938 Food, Drug, and Cosmetic Act. In 1971 FDA also took on the responsibility for consumer protection against unnecessary exposure to radiation-emitting devices for home and occupational use. However it was not until 1976, under the Medical Device Regulation Act, that the FDA was responsible for the safety and effectiveness of medical devices. This session will be presented by the Division of Radiological Health (DRH) and the Division of Imaging, Diagnostics, and Software Reliability (DIDSR) from the Center for Devices and Radiological Health (CDRH) at the FDA. The symposium will discuss on how we protect and promote public health with a focus on medical physics applications organized into four areas: pre-market device review, post-market surveillance, device compliance, current regulatory research efforts and partnerships with other organizations. The pre-market session will summarize the pathways FDA uses to regulate the investigational use and commercialization of diagnostic imaging and radiation therapy medical devices in the US, highlighting resources available to assist investigators and manufacturers. The post-market session will explain the post-market surveillance and compliance activities FDA performs to monitor the safety and effectiveness of devices on the market. The third session will describe research efforts that support the regulatory mission of the Agency. An overview of our regulatory research portfolio to advance our understanding of medical physics and imaging technologies and approaches to their evaluation will be discussed. Lastly, mechanisms that FDA uses to seek public input and promote collaborations with professional, government, and international organizations, such as AAPM, International Electrotechnical Commission (IEC), Image Gently, and the Quantitative Imaging Biomarkers Alliance (QIBA) among others, to fulfill FDA's mission will be discussed. Learning Objectives: 1. Understand FDA's pre-market and post-market review processes for medical devices 2. Understand FDA's current regulatory research activities in the areas of medical physics and imaging products 3. Understand how being involved with AAPM and other organizations can also help to promote innovative, safe and effective medical devices J. Delfino, nothing to disclose

  PublisherDOI

• Health Literacy in Vascular and Interventional Radiology: A Comparative Analysis of Online Patient Education Resources

  CardioVascular and Interventional Radiology · 2014-01-31 · 38 citations

  articleSenior authorCorresponding
  PublisherDOI

• A Critical Review of the Readability of Online Patient Education Resources From RadiologyInfo.Org

  American Journal of Roentgenology · 2014-02-20 · 87 citations

  reviewOpen access

  OBJECTIVE: Health consumers and their families rely on the Internet as a source of authoritative information regarding the procedures used to reach a diagnosis, effect treatment, and influence prognosis. In radiology, online materials can be a means by which to offer patients comprehensible explanations of the capabilities, the risks and rewards, and the techniques under our purview. Consequently, estimations of health literacy should take into account the reading level of the average American when composing and transmitting such information to the lay public without the mediation of a referring physician. MATERIALS AND METHODS: In December 2012, patient education reports from the files of RadiologyInfo.org, a jointly sponsored website of the American College of Radiology and the Radiological Society of North America, were downloaded to assess their textual sophistication. All 138 patient education articles including the glossary were analyzed for their respective level of "readability" using the following 10 evaluative scales: Flesch Reading Ease, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook Grading, Coleman-Liau Index, Gunning Fog Index, New Dale-Chall scale, FORCAST, Fry graph, Raygor Readability Estimate, and New Fog Count. RESULTS: The 138 online patient education articles were written, on average, between the 10th and 14th grade levels, which exceeds both the American Medical Association and the National Institutes of Health recommendations that patient education resources be comprehensible to those who read no higher than the seventh grade level. CONCLUSION: Patients may accrue a greater benefit from written articles available on RadiologyInfo.org if the texts were revised to be in compliance with the National Institutes of Health and American Medical Association grade level recommendations. This could lead to a broadened appreciation of the capabilities of radiology's role in general and enhanced understanding of imaging techniques and their application to clinical practice.

  PublisherOA PDFDOI

• Are We Effectively Informing Patients? A Quantitative Analysis of On-Line Patient Education Resources from the American Society of Neuroradiology

  American Journal of Neuroradiology · 2014-04-24 · 65 citations

  articleOpen access

  BACKGROUND AND PURPOSE: The ubiquitous use of the Internet by the public in an attempt to better understand their health care requires the on-line resources written at an appropriate level to maximize comprehension for the average user. The National Institutes of Health and the American Medical Association recommend on-line patient education resources written at a third-to-seventh grade level. We evaluated the readability of the patient education resources provided on the Web site of the American Society of Neuroradiology (http://www.asnr.org/patientinfo/). MATERIALS AND METHODS: All patient education material from the ASNR Web site and the Society of Neurointerventional Surgery Web site were downloaded and evaluated with the computer software, Readability Studio Professional Edition, by using 10 quantitative readability scales: the Flesch Reading Ease, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook, Coleman-Liau Index, Gunning Fog Index, New Dale-Chall, FORCAST Formula, Fry Graph, Raygor Reading Estimate, and New Fog Count. An unpaired t test was used to compare the readability level of resources available on the American Society of Neuroradiology and the Society of Neurointerventional Surgery Web sites. RESULTS: The 20 individual patient education articles were written at a 13.9 ± 1.4 grade level with only 5% written at <11th grade level. There was no statistical difference between the level of readability of the resources on the American Society of Neuroradiology and Society of Neurointerventional Surgery Web sites. CONCLUSIONS: The patient education resources on these Web sites fail to meet the guidelines of the National Institutes of Health and American Medical Association. Members of the public may fail to fully understand these resources and would benefit from revisions that result in more comprehensible information cast in simpler language.

  PublisherOA PDFDOI

• Are we failing to communicate? Internet-based patient education materials and radiation safety

  European Journal of Radiology · 2014-04-30 · 31 citations

  articleCorresponding
  PublisherDOI

• Abstract No. 350 EE: Self Expandable Nitinol Stent for Post Liver Transplant Portal Vein Stenosis (PVS). Technical Aspects and Long Term Follow Up

  Journal of Vascular and Interventional Radiology · 2009-01-27

  articleOpen access
  PublisherOA PDFDOI

• Single-incision Technique for Tunneled Central Venous Access

  Journal of Vascular and Interventional Radiology · 2009-07-31 · 14 citations

  article
  PublisherDOI

Frequent coauthors

• Andrew N. de la Torre

  Rutgers New Jersey Medical School

  12 shared

• Sohail Contractor

  University of Louisville

  11 shared

• David Klyde

  Rutgers, The State University of New Jersey

  11 shared

• Nitin Agarwal

  University of Pittsburgh Medical Center

  11 shared

• P. Kisza

  10 shared

• David R. Hansberry

  Drexel University

  8 shared

• Stephen R. Baker

  Saint Francis University

  5 shared

• Carl N. Kraus

  5 shared

Labs

• Rutgers New Jersey Medical School Department of RadiologyPI

Education

• M.D.

  UMDNJ-NJMS

  2003

• B.S., Biomedical Engineering

  Rutgers University

  1999