About

Ye Xia is an Associate Professor in the Department of Plant Pathology at The Ohio State University. Her research focuses on the biochemistry of plant pathogenesis and immunity. She is based in 477C Kottman Hall, Columbus, and can be contacted via email at xia.374@osu.edu or by phone at 614-292-1789. The information provided indicates her role and research area but does not include further details about her background, specific research projects, or key contributions.

Research topics

• Biology
• Fishery
• Environmental engineering
• Medicine
• Biochemistry
• Oncology
• Environmental science
• Pathology
• Pharmacology
• Internal medicine
• Bioinformatics
• Geography
• Microbiology

Selected publications

• Construction and implementation of a death education program for nursing interns: an action research study

  BMC Medical Education · 2026-01-07 · 1 citations

  articleOpen access

  Nursing interns frequently encounter patient death but are often inadequately prepared for end-of-life care, leading to distress and reduced efficacy. Existing death education programs rarely address their specific needs. To develop and evaluate a tailored death education program for nursing interns. The study was conducted in two phases: development and refinement of a preliminary program through literature review, interviews, Delphi method, and the first action research cycle; followed by evaluation via a second action research cycle with 48 interns (24 per cycle). Quantitative outcomes were assessed using the Death Attitude Profile-Revised (DAP-R), Frommelt Attitude Toward Care of the Dying scale (FATCOD-B), and Coping with Death Scale (CDS) scales, while qualitative data were collected through semi-structured interviews and participatory observation. After the second cycle, significant improvements (P < 0.05) were observed across all DAP-R dimensions, FATCOD-B total score, and CDS total score. The second cycle yielded significantly greater improvements in most outcomes compared to the first (P < 0.05), except for Escape Acceptance (P = 0.073). Qualitative analysis identified three themes: reflections and recommendations on death education workshops; development of end-of-life communication skills and deepening death awareness and Internalized development of life care and empathy capacity. The action research-based program effectively improved nursing interns’ death coping, end-of-life care attitudes, and communication skills, supporting the integration of experiential and reflective pedagogies into palliative care education.

  PublisherDOI

• Prediction of Symptom Burden, Cognitive Status, and Risk of Psychological Distress in NCAA Athletes with Sport-Related Concussion(s): Findings from the NCAA-DoD CARE Consortium

  Annals of Biomedical Engineering · 2025-08-14 · 4 citations

  article
  PublisherDOI

• Influence of aquaculture practices on microbiota composition and pathogen abundance in pond ecosystems in South China

  Water Research X · 2025-01-10 · 10 citations

  articleOpen access

  • Aquaculture practices significantly impact pond microbiota composition. • NH 4 + -N concentration increases pathogenic bacteria in pond water. • Higher nitrogen levels enhance Mycobacterium abundance in pond water. • Culture patterns and species affect Vibrio, Tenacibaculum , and Francisella abundance. • Pathogenic bacteria are more abundant in sediment than in water. Pond microbiota play a crucial role in maintaining water quality and the health of aquaculture species. This study aimed to explore the relationship between pond water and sediment microbiota (especially potential pathogens) and physicochemical parameters under different aquaculture conditions. Samples of pond water and sediment were collected from 21 monitoring sites across eastern, western, and northern Guangdong, and the Pearl River Delta in November 2021, March 2022, and July 2022. Microbial structures were analyzed using high-throughput sequencing of the 16S rRNA gene. The results indicated that sediment microbiota distribution was more uniform than that of water microbiota. Additionally, sampling time significantly influenced the uniformity of water microbiota distribution more than that sediment microbiota. Factors such as aquaculture species, culture pattern, NH 4 + -N, longitude, latitude, total nitrogen (TN), NO 3 − -N, NO 2 − -N, and total phosphorus (TP) were significantly correlated with water microbiota structure, and TN, TP, and organic carbon were significantly correlated with sediment microbiota structure. Furthermore, an increase in the NH 4 + -N concentration in the pond water significantly increased the variety of pathogenic bacteria. Higher nitrogen levels also increased the relative abundance of Mycobacterium in pond water, whereas the culture pattern (freshwater, seawater, brackish, modern captive culture, freshwater factory container aquaculture, or seawater factory culture) and species significantly influenced the relative abundances of Vibrio, Tenacibaculum, Pseudoalteromonas , and Francisella . Additionally, the relative abundance of pathogenic bacteria in the sediment microbiota was significantly higher than that in the water microbiota. Our results suggest that the culture patterns, species, and nitrogen concentrations should be considered when preventing pathogenic bacteria growth in aquaculture waters.

  PublisherDOI

• Effects of berberine combined with Pennisetum sinese Roxb meal on growth, hepatic lipid metabolism, and intestinal health of grass carp, Ctenopharyngodon idella

  Aquaculture Reports · 2025-02-20 · 1 citations

  articleOpen access

  Intestinal inflammation and hepatic fat accumulation syndrome is a major issue in farmed fish. In this study, grass carp (20.3 ± 0.1 g) were fed for 8 weeks with six feeds containing different Pennisetum sinese Roxb meal (PSRM) levels (0, 5, 10 %) and 0 or 0.1 % berberine (BBR). Growth remained unaffected by BBR and PSRM. PSRM reduced the CF, HI, and VSI, whereas BBR had no such effect or interaction. PSRM (not BBR) suppressed the activities of serum AST and ALT, as well as the contents of LDL - c, T - CHO, and TG ( P < 0.05). However, BBR only interacted with the effects of PSRM on the AST and ALT activities ( P < 0.01). BBR and PSRM decreased hepatic lipid droplet deposition and TG/T - CHO contents ( P < 0.01), without interaction. Transcriptionally, both BBR and PSRM suppressed the lipogenic genes PPARγ, ACC, and SCD ( P < 0.01) and upregulated the lipolytic genes PPARα, ATGL, and APOE ( P < 0.01), mostly without interaction. Intestinal immunohistochemistry revealed TNF - α below intestinal villi and IL - 6 on the upper side of villi and in lamina propria, both reduced in fish fed PSRM - and BBR - supplemented diets ( P < 0.05). BBR and PSRM suppressed pro - inflammatory (TNF - α, IL - 6, IL - 8) and ER stress genes (GPR78, ATF6, IRE - 1α, PERK), and promoted anti - inflammatory (TGF - β1, IL - 4/13 A), with interaction on TNF - α, IL - 8, GRP78, PERK, TGF - β1 ( P < 0.05). BBR and PSRM triggered the FXR signaling pathway in liver and intestine, with BBR interacting with PSRM on most genes. Overall, BBR didn't disrupt PSRM-induced benefits on body morphology, had no superimposed effect on intestinal health but a synergistic effect on fat reduction. • The combined effects of Pennisetum sinese Roxb meal (PSRM) and berberine (BBR) on grass carp were evaluated. • Growth was not affected by BBR and PSRM, but PSRM was beneficial to body indices while BBR did not interfere. • BBR and PSRM have a synergistic effect on serum and hepatic fat reduction. • Both BBR and PSRM are beneficial to intestinal health, but there is no superimposed effect. • Both BBR and PSRM activated the FXR signaling pathways in the intestine and liver.

  PublisherDOI

• Exploring the application of Heart to Heart Cards in hospice care education for nursing students: a qualitative study

  BMC Nursing · 2025-11-28

  articleOpen accessCorresponding

  BACKGROUND: Hospice care education is crucial for preparing nursing students to provide holistic end-of-life care. However, traditional pedagogical models often over-rely on one-way knowledge transmission, creating a theory-practice gap and neglecting emotional education. The Heart to Heart Card (HHC), an interactive card-based tool, presents a potential innovative solution. This study qualitatively explored undergraduate nursing students' experiential perceptions of integrating the HHC into a hospice care course. METHODS: A descriptive phenomenological design was employed. Seventeen undergraduate nursing students enrolled in a hospice care elective course were purposively sampled and participated in one-on-one, in-depth, semi-structured interviews between November 2024 and March 2025. Data were analyzed using Colaizzi's seven-step phenomenological method. RESULTS: Three primary thematic categories emerged from the data analysis: (1) direct impressions and refinement recommendations for HHC within the course, (2) immersive learning and insights from the "Heart to Heart Tea House", (3) practical challenges in transitioning HHC application from simulations to clinical settings. CONCLUSION: The HHC serves as an effective pedagogical tool for enhancing hospice care education, as it successfully bridges theory and practice, improving communication skills, and fostering humanistic competencies through its theoretical-practical integration. Further refinements in HHC design and implementation strategies are needed to optimize its applicability across diverse clinical scenarios and cultural contexts.

  PublisherDOI

• C4-HSL drives rapid biofilm formation in low-temperature aquaculture effluent: strengthening structural stability of biofilm and improving nitrogen removal efficiency

  Environmental Research · 2025-07-21 · 4 citations

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  PublisherDOI

• Multi-Parameter Optimization of Vertical Flow Constructed Wetlands to Enhance Synergistic Action Among Substrate, Plants, and Microorganisms

  SSRN Electronic Journal · 2025-01-01

  preprintOpen access
  PublisherDOI

• Comparative analysis of muscle metabolomics and gut microbiome provides new insights into the high fat intolerance mechanism of juvenile grass carp, Ctenopharyngodon idella

  Aquaculture Reports · 2025-05-09 · 1 citations

  articleOpen access

  In aquaculture, increasing dietary fat levels can help to spare expensive protein resources and reduce water pollution. In some fish species, such as herbivorous fish, limited tolerance to dietary fat has emerged as a key factor affecting aquaculture sustainability, although the underlying mechanisms remain poorly understood. To address this, we investigated changes in juvenile grass carp Ctenopharyngodon idella on growth, muscle metabolomics, and gut microbiota in response to dietary lipid levels. A total of 270 fish (33.28 ± 0.05 g) were randomly assigned to three groups (triplicate) and fed isonitrogenous diets (30 % protein) with graded lipid levels (5 % control, 7 % and 9 % high-fat) for 8 weeks. Relative to the control, growth was enhanced at 7 % lipids but was significantly reduced at 9 % lipids ( P < 0.05). The visceral and mesenteric fat ratios were elevated at 7 % and 9 % lipids and were highest at 7 % lipids ( P < 0.05). Myocyte diameters were smallest in the control and largest at 7 % lipids ( P < 0.05). Muscle metabolomics were significantly altered, at 7 %, the primary enriched metabolic pathways were lysine biosynthesis and glycine metabolism, while at 9 %, they were purine metabolism and taste transduction. Increasing lipid levels reduced the number of operational taxonomic units number and α-diversity of the gut microbiota. Bacteroidota abundance and phytuberin levels were significantly positively correlated at 7 % lipids; similarly Nakamurella abundance and guanosine levels showed a significant positive correlation at 9 % lipids ( P < 0.05). Unclassified_f_Rhodobacteraceae abundance and acetic acid levels were negatively correlated at 9 % lipids ( P < 0.05). Overall, Grass carp responded differently to varying dietary lipid levels. A moderate lipid increase (7 %) improved growth and affected amino acid metabolism, while excessive lipid levels (9 %) inhibited growth and altered muscle energy balance and nerve conduction. These effects were partly correlated with changes in the gut microbiota. • A 7 % lipid diet enhances grass carp growth and myocyte hypertrophy, whereas 9 % inhibits growth. • A 7 % high-fat diet alters muscle amino acid metabolism, particularly the lysine pathway. • A 9 % high-fat diet disrupts muscle energy and nerve function in grass carp. • High-fat diets modify grass carp gut microbiota, decreasing diversity. • Gut microbiota partially correlates with changes in muscle metabolites.

  PublisherDOI

• Nursing Interns' Perspectives on Good Death: Insights from the Heart to Heart Tea House

  American Journal of Hospice and Palliative Medicine® · 2025-10-24

  articleSenior author

  ObjectivesThis study aimed to: (1) explore Chinese nursing interns' perspectives on a "good death" through their participation in the Heart to Heart Tea House; (2) derive insights for nursing education; and (3) inform the improvement of end-of-life care narratives in China.MethodsUsing convenience sampling, 24 nursing interns participated in the Heart to Heart Tea House activity in eight groups of three. Each group engaged in facilitated discussions centered around three self-selected cards. All dialogue was recorded verbatim and analyzed using Braun and Clarke's thematic analysis until data saturation was reached, with no new themes emerging from subsequent interviews.ResultsFour main themes emerged: (1) emphasis on autonomy and dignity in end-of-life care, (2) natural acceptance of death and reflections on life's meaning, (3) the need for comfort and physical care in the terminal stage, and (4) considerations of social relationships and emotional support. The interns highlighted the importance of respecting individual choices, maintaining dignity, achieving a peaceful state of mind, managing physical symptoms, and fulfilling emotional expressions.ConclusionThe Heart to Heart Tea House proved to be an effective platform for nursing interns to reflect on and articulate their views regarding a good death. The findings offer valuable guidance for developing targeted nursing education programs and enhancing patient-centered end-of-life care services, emphasizing the significance of integrating such initiatives into healthcare practice.

  PublisherDOI

• Optimization of aquaculture wastewater treatment systems: based on the isolation of the strain Acinetobacter sp. LF10

  Bioresource Technology · 2025-08-06 · 2 citations

  article
  PublisherDOI

Recent grants

• NIH Grant K08DK060468

  NIH · $652k · 2009

Frequent coauthors

• Thomas J. Papadimos

  77 shared

• Xuzhong Xu

  75 shared

• Ermeng Yu

  Chinese Academy of Fishery Sciences

  69 shared

• Jackie D. Wood

  Phillips Exeter Academy

  59 shared

• Jingjing Tian

  Tsinghua University

  57 shared

• Wangbao Gong

  Chinese Academy of Fishery Sciences

  49 shared

• Quanguang Wang

  Wenzhou Medical University

  44 shared

• Sumei Liu

  University of Wisconsin–La Crosse

  44 shared

Labs

• Paul LabPI

Education

• Ph.D., Plant Pathology

  The Ohio State University

  2010

• M.S., Plant Pathology

  The Ohio State University

  2006

• B.S., Plant Pathology

  The Ohio State University

  2004

Awards & honors

• A. J. Hoffmann Award
• CC Allison Award
• Grad News Awards 1986-2007