About

Stephanie Brown is an Associate Professor in the Department of English at The Ohio State University. She holds a PhD from Columbia University and specializes in twentieth- and twenty-first-century American literature, African American literature, critical theory, and speculative fiction. Brown is the author of The Postwar African American Novel: Protest and Discontent, 1945-1950, published in 2011, and co-editor of Engaging Tradition, Making It New: Essays on Teaching Recent African American Literature (2008). She has published numerous articles on African American literature and culture. Her recent work integrates her research with study abroad programs in Berlin, exploring themes of cosmopolitanism and student engagement. Currently, she is working on a book-length study examining genre blurring in twenty-first-century historical and speculative fiction.

Research topics

• Computer Science

Selected publications

• Frontmatter

  New York University Press eBooks · 2020-12-31

  book-chapterOpen access
  PublisherOA PDFDOI

• Frontmatter

  New York University Press eBooks · 2020-12-31

  book-chapterOpen access
  PublisherOA PDFDOI

• Frontmatter

  New York University Press eBooks · 2020-12-31

  book-chapterOpen access
  PublisherOA PDFDOI

• Frontmatter

  New York University Press eBooks · 2020-03-03

  book-chapterOpen access
  PublisherOA PDFDOI

• Frontmatter

  New York University Press eBooks · 2020

  • Computer Science
  • Computer Science
  DOI

• Effecting Institutional Change

  Bulletin of the American Physical Society · 2018-11-17

  article1st authorCorresponding
  Publisher

• A Low-Waste Process To Sertraline By Diastereomeric Crystal Resolution and Waste Isomer Racemisation

  Organic Process Research & Development · 2009-07-17 · 19 citations

  article

  A semi-continuous method for recovering waste sertraline isomers from a diastereomeric crystallisation process is described in which the mother liquors from a highly selective mandelic acid resolution for the (1S,4S) isomer are treated sequentially with SCRAM, an iridium-based chiral amine racemisation catalyst, and then catalytic potassium tertiary butoxide to epimerise the methine chiral centre. The green, low-waste process also deals with recovery and recycle of the precious-metal catalyst, providing both good economics and high-quality product.

  PublisherDOI

• Generation of a dynamic combinatorial library using sialic acid aldolase and in situ screening against wheat germ agglutinin

  Tetrahedron · 2003-12-16 · 29 citations

  articleSenior author
  PublisherDOI

• Enzymatic Generation and In Situ Screening of a Dynamic Combinatorial Library of Sialic Acid Analogues

  Angewandte Chemie International Edition · 2002-09-16 · 45 citations

  articleSenior author

  Reversible formation of carbon–carbon bonds under physiological conditions by enzyme catalysis allows the generation and in situ screening of a dynamic mixture of biologically significant compounds. Generation of the dynamic library by incubation of the three sugars 1 a–c with two equivalents of sodium pyruvate in the presence of N-acetylneuraminic acid aldolase and wheat germ agglutinin resulted in amplification of sialic acid 1 a (see scheme).

  PublisherDOI

• A common regulatory locus affects both HNF4/HNF1α pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells

  Journal of Cell Science · 2001-03-15 · 11 citations

  articleCorresponding

  Lipopolysaccharide (LPS) has been shown to protect certain cultured mammalian cells from undergoing programmed cell death (apoptosis) when exposed to tumor necrosis factor (TNF). However, LPS has also been reported to induce apoptosis in cultured endothelial cells, suggesting that apoptotic response mechanisms may be dependent upon cell type. In order to understand the influence of tissue-specific gene expression on apoptosis, we compared LPS-induced apoptosis in hepatoma cells with dedifferentiated hepatoma variant cells that have been selected for the loss of the liver-enriched HNF4/HNF1alpha transcriptional activation pathway. We report here that while human, rat and mouse hepatoma cell lines are resistant to LPS-mediated cell death, the HNF4-/HNF1alpha- rat hepatoma variant cells undergo rapid apoptosis (as determined by morphological analysis, DNA laddering and the TUNEL assay) upon exposure to LPS. Genetic rescue experiments show that restoration of the HNF4/HNF1alpha pathway via chromosome transfer render the hepatoma variant cells resistant to LPS-mediated apoptosis. However, the introduction of HNF1alpha alone failed to alter the apoptotic phenotype, suggesting that the defect(s) in the hepatoma variant cells that influence apoptotic responses lies upstream of HNF4/HNF1alpha expression. This study provides for the first time direct evidence of a common regulatory locus involved in activation of hepatic gene expression and sensitivity to LPS-mediated apoptosis.

  PublisherDOI

Frequent coauthors

• Joseph Lowry

  2835 shared

• Devin J. Stewart

  Emory University

  2835 shared

• Shawkat M. Toorawa

  2835 shared

• Julia Bray

  University of Cambridge

  2835 shared

• James E. Montgomery

  Covenant Medical Center

  2835 shared

• Philip Kennedy

  Neural Signals (United States)

  2737 shared

• Chip Rossetti

  Carleton University

  2477 shared

• Tahera Qutbuddin

  Carleton University

  2477 shared